Search Results - "Marshansky, Vladimir"

The V-type H+ -ATPase in vesicular trafficking: targeting, regulation and function by Marshansky, Vladimir, Futai, Masamitsu

“…Vacuolar-type H+ -ATPase (V-ATPase)-driven proton pumping and organellar acidification is essential for vesicular trafficking along both the exocytotic and…”
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Eukaryotic V-ATPase: Novel structural findings and functional insights by Marshansky, Vladimir, Rubinstein, John L., Grüber, Gerhard

“…The eukaryotic V-type adenosine triphosphatase (V-ATPase) is a multi-subunit membrane protein complex that is evolutionarily related to F-type adenosine…”
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Mapping the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation by Merkulova, Maria, Păunescu, Teodor G., Azroyan, Anie, Marshansky, Vladimir, Breton, Sylvie, Brown, Dennis

“…V-ATPases (H + ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell…”
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Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking by Brown, Dennis, Paunescu, Teodor G, Breton, Sylvie, Marshansky, Vladimir

“…The proton-pumping V-ATPase is a complex, multi-subunit enzyme that is highly expressed in the plasma membranes of some epithelial cells in the kidney,…”
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Renal Vacuolar H+-ATPase by Wagner, Carsten A, Finberg, Karin E, Breton, Sylvie, Marshansky, Vladimir, Brown, Dennis, Geibel, John P

“…Institute of Physiology, University of Zurich, Zurich, Switzerland; Departments of Genetics, Cellular and Molecular Physiology, and Surgery, School of…”
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Sensing, Signaling and Sorting Events in Kidney Epithelial Cell Physiology by Brown, Dennis, Breton, Sylvie, Ausiello, Dennis A, Marshansky, Vladimir

“…The kidney regulates body fluid, ion and acid/base homeostasis through the interaction of a host of channels, transporters and pumps within specific tubule…”
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The N Termini of a-Subunit Isoforms Are Involved in Signaling between Vacuolar H+-ATPase (V-ATPase) and Cytohesin-2[S] by Hosokawa, Hiroyuki, Dip, Phat Vinh, Merkulova, Maria, Bakulina, Anastasia, Zhuang, Zhenjie, Khatri, Ashok, Jian, Xiaoying, Keating, Shawn M., Bueler, Stephanie A., Rubinstein, John L., Randazzo, Paul A., Ausiello, Dennis A., GrÜber, Gerhard, Marshansky, Vladimir

“…Previously, we reported an acidification-dependent interaction of the endosomal vacuolar H+-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor…”
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The absence of a clathrin adapter confers unique polarity essential to proximal tubule function by Schreiner, Ryan, Frindt, Gustavo, Diaz, Fernando, Carvajal-Gonzalez, Jose M., Perez Bay, Andrés E., Palmer, Lawrence G., Marshansky, Vladimir, Brown, Dennis, Philp, Nancy J., Rodriguez-Boulan, Enrique

“…It is well established that many cognate basolateral plasma membrane proteins are expressed apically in proximal tubule cells thus optimizing the reabsorption…”
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Discovery and Study of Transmembrane Rotary Ion-Translocating Nano-Motors: F-ATPase/Synthase of Mitochondria/Bacteria and V-ATPase of Eukaryotic Cells by Marshansky, Vladimir

“…This review discusses the history of discovery and study of the operation of the two rotary ion-translocating ATPase nano-motors: (i) F-ATPase/synthase…”
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Intra-endosomal pH-sensitive Recruitment of the Arf-nucleotide Exchange Factor ARNO and Arf6 from Cytoplasm to Proximal Tubule Endosomes by Maranda, Bruno, Brown, Dennis, Bourgoin, Sylvain, Casanova, James E., Vinay, Patrick, Ausiello, Dennis A., Marshansky, Vladimir

“…Kidney proximal tubule epithelial cells have an extensive apical endocytotic apparatus that is critical for the reabsorption and degradation of proteins that…”
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Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition by Bagnis, C, Marshansky, V, Breton, S, Brown, D

“…Factors regulating the differentiated phenotype of principal cells (PC) and A- and B-intercalated cells (IC) in kidney collecting ducts are poorly understood…”
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Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells by Marshansky, Vladimir, Wang, Xin, Bertrand, Richard, Luo, Hongyu, Duguid, William, Chinnadurai, G, Kanaan, Nada, Vu, Minh Diem, Wu, Jiangping

“…The mechanism underlying apoptosis induced by proteasome inhibition in leukemic Jurkat and Namalwa cells was investigated in this study. The proteasome…”
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Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway by Bouley, Richard, Lin, Herbert Y, Raychowdhury, Malay K, Marshansky, Vladimir, Brown, Dennis, Ausiello, Dennis A

“…Vasopressin (VP) increases urinary concentration by signaling through the vasopressin receptor (V2R) in collecting duct principal cells. After downregulation,…”
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Targeting the calorie restriction pathway: Cytohesin1/2 as a drug target in cancer, aging and age-related diseases by Marshansky, Vladimir, Bhargava, Ajay

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Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ by El-Annan, Jaafar, Brown, Dennis, Breton, Sylvie, Bourgoin, Sylvain, Ausiello, Dennis A, Marshansky, Vladimir

“…ADP-ribosylation factors (Arfs) are small GTPases that regulate vesicular trafficking in exo- and endocytotic pathways. As a first step in understanding the…”
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Proton gradient formation in early endosomes from proximal tubules by Marshansky, Vladimir, Vinay, Patrick

“…Heavy endosomes were isolated from proximal tubules using a combination of magnesium precipitation and wheat-germ agglutinin negative selection techniques. Two…”
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New insights into structure-function relationships between archeal ATP synthase (A₁A₀) and vacuolar type ATPase (V₁V₀) by Grüber, Gerhard, Marshansky, Vladimir

“…Adenosine triphosphate, ATP, is the energy currency of living cells. While ATP synthases of archae and ATP synthases of pro- and eukaryotic organisms operate…”
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Receptor-mediated endocytosis in kidney proximal tubules: recent advances and hypothesis by Marshansky, V, Bourgoin, S, Londoño, I, Bendayan, M, Maranda, B, Vinay, P

“…Preparation of kidney proximal tubules in suspension allows the study of receptor-mediated endocytosis, protein reabsorption, and traffic of endosomal…”
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Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situ by Zhuang, Zhenjie, Marshansky, Vladimir, Breton, Sylvie, Brown, Dennis

“…Kidney proximal tubule (PT) cells are specialized for the uptake and transport of ions, solutes, peptides, and proteins. These functions are often regulated by…”
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Postnatal Establishment of Allelic Gαs Silencing as a Plausible Explanation for Delayed Onset of Parathyroid Hormone Resistance Owing to Heterozygous Gαs Disruption by Turan, Serap, Fernandez‐Rebollo, Eduardo, Aydin, Cumhur, Zoto, Teuta, Reyes, Monica, Bounoutas, George, Chen, Min, Weinstein, Lee S, Erben, Reinhold G, Marshansky, Vladimir, Bastepe, Murat

“…ABSTRACT Pseudohypoparathyroidism type‐Ia (PHP‐Ia), characterized by renal proximal tubular resistance to parathyroid hormone (PTH), results from maternal…”
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