Search Results - "Marshall, Richard P"

Dissecting fibrosis: therapeutic insights from the small-molecule toolbox by Nanthakumar, Carmel B., Hatley, Richard J. D., Lemma, Seble, Gauldie, Jack, Marshall, Richard P., Macdonald, Simon J. F.

“…Key Points The search for new therapeutics for fibrosis has recently increased owing to recent drug approvals coupled with advances in mechanistic insight and…”
Get full text

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis by Gevaert, Philippe, MD, PhD, Van Bruaene, Nicholas, MD, Cattaert, Tom, PhD, Van Steen, Kristel, PhD, Van Zele, Thibaut, MD, PhD, Acke, Frederic, MD, De Ruyck, Natalie, MSc, Blomme, Katrien, MSc, Sousa, Ana R., PhD, Marshall, Richard P., MD, PhD, Bachert, Claus, MD, PhD

“…Background Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic…”
Get full text

Daily Home Spirometry: An Effective Tool for Detecting Progression in Idiopathic Pulmonary Fibrosis by Russell, Anne-Marie, Adamali, Huzaifa, Molyneaux, Philip L, Lukey, Pauline T, Marshall, Richard P, Renzoni, Elisabetta A, Wells, Athol U, Maher, Toby M

“…Recent clinical trial successes have created an urgent need for earlier and more sensitive endpoints of disease progression in idiopathic pulmonary fibrosis…”
Get full text

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis by Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.

“…Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic…”
Get full text

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma by Haldar, Pranabashis, Brightling, Christopher E, Hargadon, Beverley, Gupta, Sumit, Monteiro, William, Sousa, Ana, Marshall, Richard P, Bradding, Peter, Green, Ruth H, Wardlaw, Andrew J, Pavord, Ian D

“…Asthma exacerbations are characterized by increased symptoms of cough and chest tightness, diminished expiratory airflow, and increased numbers of inflammatory…”
Get full text

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study by Jenkins, R Gisli, PhD, Simpson, Juliet K, PhD, Saini, Gauri, MD, Bentley, Jane H, PhD, Russell, Anne-Marie, MSc, Braybrooke, Rebecca, RGN, Molyneaux, Philip L, MD, McKeever, Tricia M, PhD, Wells, Athol U, MD, Flynn, Aiden, PhD, Hubbard, Richard B, Prof, Leeming, Diana J, PhD, Marshall, Richard P, PhD, Karsdal, Morten A, PhD, Lukey, Pauline T, PhD, Maher, Toby M, Dr

“…Summary Background Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect…”
Get full text

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF by Mercer, Paul F, Woodcock, Hannah V, Eley, Jessica D, Platé, Manuela, Sulikowski, Michal G, Durrenberger, Pascal F, Franklin, Linda, Nanthakumar, Carmel B, Man, Yim, Genovese, Federica, McAnulty, Robin J, Yang, Shuying, Maher, Toby M, Nicholson, Andrew G, Blanchard, Andy D, Marshall, Richard P, Lukey, Pauline T, Chambers, Rachel C

“…Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal of all fibrotic conditions with no curative therapies. Common pathomechanisms…”
Get more information

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study by Maher, Toby M, Oballa, Eunice, Simpson, Juliet K, Porte, Joanne, Habgood, Anthony, Fahy, William A, Flynn, Aiden, Molyneaux, Philip L, Braybrooke, Rebecca, Divyateja, Hrushikesh, Parfrey, Helen, Rassl, Doris, Russell, Anne-Marie, Saini, Gauri, Renzoni, Elisabetta A, Duggan, Anne-Marie, Hubbard, Richard, Wells, Athol U, Lukey, Pauline T, Marshall, Richard P, Jenkins, R Gisli

“…Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease trajectory. The aim of this study was to assess potential…”
Get full text

Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients by Gupta, Sumit, PhD, MRCP, Hartley, Ruth, MBChB, MRCS, Khan, Umair T., MBChB, Singapuri, Amisha, BSc, Hargadon, Beverly, RGN, Monteiro, William, MSc, Pavord, Ian D., DM, FRCP, Sousa, Ana R., PhD, Marshall, Richard P., PhD, MRCP, Subramanian, Deepak, MD, MRCP, Parr, David, MD, FRCP, Entwisle, James J., MBBS, FRCR, Siddiqui, Salman, PhD, MRCP, Raj, Vimal, MBBS, FRCR, Brightling, Christopher E., PhD, FRCP

“…Background Asthma heterogeneity is multidimensional and requires additional tools to unravel its complexity. Computed tomography (CT)–assessed proximal airway…”
Get full text

Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort by Organ, Louise A, Duggan, Anne-Marie R, Oballa, Eunice, Taggart, Sarah C, Simpson, Juliet K, Kang'ombe, Arthur R, Braybrooke, Rebecca, Molyneaux, Philip L, North, Bernard, Karkera, Yakshitha, Leeming, Diana J, Karsdal, Morten A, Nanthakumar, Carmel B, Fahy, William A, Marshall, Richard P, Jenkins, R Gisli, Maher, Toby M

“…Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM) deposition and remodelling. Measuring this activity provides an…”
Get full text

Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study by Hartley, Ruth A., MBcHB, MRCS, Barker, Bethan L., MBBS, MRCP, Newby, Chris, PhD, Pakkal, Mini, FRCR, Baldi, Simonetta, MD, PhD, Kajekar, Radhika, PhD, Kay, Richard, PhD, Laurencin, Marie, PhD, Marshall, Richard P., PhD, MRCP, Sousa, Ana R., PhD, Parmar, Harsukh, PhD, Siddiqui, Salman, PhD, MRCP, Gupta, Sumit, PhD, FRCR, MRCP, Brightling, Chris E., PhD, FRCP

“…Background There is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic…”
Get full text

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor by Maher, Toby M, Simpson, Juliet K, Porter, Joanna C, Wilson, Frederick J, Chan, Robert, Eames, Rhena, Cui, Yi, Siederer, Sarah, Parry, Simon, Kenny, Julia, Slack, Robert J, Sahota, Jagdeep, Paul, Lyn, Saunders, Peter, Molyneaux, Philip L, Lukey, Pauline T, Rizzo, Gaia, Searle, Graham E, Marshall, Richard P, Saleem, Azeem, Kang'ombe, Arthur R, Fairman, David, Fahy, William A, Vahdati-Bolouri, Mitra

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the…”
Get full text

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis by Usmani, Omar S, Biddiscombe, Martyn F, Yang, Shuying, Meah, Sally, Oballa, Eunice, Simpson, Juliet K, Fahy, William A, Marshall, Richard P, Lukey, Pauline T, Maher, Toby M

“…Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF). The TOPICAL study was a…”
Get full text

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis by Woodcock, Hannah V., Eley, Jessica D., Guillotin, Delphine, Platé, Manuela, Nanthakumar, Carmel B., Martufi, Matteo, Peace, Simon, Joberty, Gerard, Poeckel, Daniel, Good, Robert B., Taylor, Adam R., Zinn, Nico, Redding, Matthew, Forty, Ellen J., Hynds, Robert E., Swanton, Charles, Karsdal, Morten, Maher, Toby M., Fisher, Andrew, Bergamini, Giovanna, Marshall, Richard P., Blanchard, Andy D., Mercer, Paul F., Chambers, Rachel C.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Severe Asthma: differential chemokine response of airway epithelial cells by Thomas, Biju, MD, Anthony Hirst, Robert, PhD, H Brett-Pitt, Mina, PhD, Williams, Gwyneth, CBiol, Andrew, Peter W., PhD, Sousa, Ana R., PhD, Marshall, Richard P., PhD, Brightling, Chrostopher, PhD, O’Callaghan, Christopher, PhD

“…The differential chemokine response of airway basal cells of severe asthma patients to Streptococcus pneumoniae and Dermatophagoides pteronyssinus allergen may…”
Get full text

Angiotensin II and the fibroproliferative response to acute lung injury by Marshall, Richard P, Gohlke, Peter, Chambers, Rachel C, Howell, David C, Bottoms, Steve E, Unger, Thomas, McAnulty, Robin J, Laurent, Geoffrey J

“…Angiotensin II (ANG II), generated by activation of local renin-angiotensin systems, is believed to play an important role in tissue repair and remodeling, in…”
Get more information

Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome by MARSHALL, Richard P, BELLINGAN, Geoffrey, WEBB, Suzanne, PUDDICOMBE, Anna, GOLDSACK, Neil, MCANULTY, Robin J, LAURENT, Geoffrey J

“…The fibroproliferative phase of acute respiratory distress syndrome (ARDS) has traditionally been regarded as a late event but recent studies that suggest…”
Get full text

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine by Falsey, Ann R, Sobieszczyk, Magdalena E, Hirsch, Ian, Sproule, Stephanie, Robb, Merlin L, Corey, Lawrence, Neuzil, Kathleen M, Hahn, William, Hunt, Julie, Mulligan, Mark J, McEvoy, Charlene, DeJesus, Edwin, Hassman, Michael, Little, Susan J, Pahud, Barbara A, Durbin, Anna, Pickrell, Paul, Daar, Eric S, Bush, Larry, Solis, Joel, Carr, Quito Osuna, Oyedele, Temitope, Buchbinder, Susan, Cowden, Jessica, Vargas, Sergio L, Guerreros Benavides, Alfredo, Call, Robert, Keefer, Michael C, Kirkpatrick, Beth D, Pullman, John, Tong, Tina, Brewinski Isaacs, Margaret, Benkeser, David, Janes, Holly E, Nason, Martha C, Green, Justin A, Kelly, Elizabeth J, Maaske, Jill, Mueller, Nancy, Shoemaker, Kathryn, Takas, Therese, Marshall, Richard P, Pangalos, Menelas N, Villafana, Tonya, Gonzalez-Lopez, Antonio

“…In a randomized, double-blind, placebo-controlled phase 3 trial of the ChAdOx1 nCoV-19 vaccine in over 32,000 participants from the United States, Chile, and…”
Get full text

Reduced need for surgery in severe nasal polyposis with mepolizumab: Randomized trial by Bachert, Claus, Sousa, Ana R., Lund, Valerie J., Scadding, Glenis K., Gevaert, Philippe, Nasser, Shuaib, Durham, Stephen R., Cornet, Marjolein E., Kariyawasam, Harsha H., Gilbert, Jane, Austin, Daren, Maxwell, Aoife C., Marshall, Richard P., Fokkens, Wytske J.

“…Patients with eosinophilic nasal polyposis frequently require surgery, and recurrence rates are high. We sought to assess the efficacy and safety of…”
Get full text

Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor by MARSHALL, R. P, MCANULTY, R. J, LAURENT, G. J

“…The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests…”
Get full text