Search Results - "Marshall, Owen J."

damidseq_pipeline: an automated pipeline for processing DamID sequencing datasets by Marshall, Owen J, Brand, Andrea H

“…DamID is a powerful technique for identifying regions of the genome bound by a DNA-binding (or DNA-associated) protein. Currently, no method exists for…”
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Chromatin state changes during neural development revealed by in vivo cell-type specific profiling by Marshall, Owen J., Brand, Andrea H.

“…A key question in developmental biology is how cellular differentiation is controlled during development. While transitions between trithorax-group (TrxG) and…”
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PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR by MARSHALL, Owen J

“…PerlPrimer is a cross-platform graphical user interface application for the design of primers for standard, bisulphite and real-time PCR, and sequencing. The…”
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Cell-Type-Specific Profiling of Gene Expression and Chromatin Binding without Cell Isolation: Assaying RNA Pol II Occupancy in Neural Stem Cells by Southall, Tony D., Gold, Katrina S., Egger, Boris, Davidson, Catherine M., Caygill, Elizabeth E., Marshall, Owen J., Brand, Andrea H.

“…Cell-type-specific transcriptional profiling often requires the isolation of specific cell types from complex tissues. We have developed “TaDa,” a technique…”
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Active transcription and essential role of RNA polymerase II at the centromere during mitosis by Chan, F. Lyn, Marshall, Owen J, Saffery, Richard, Won Kim, Bo, Earle, Elizabeth, Choo, K. H. Andy, Wong, Lee H

“…Transcription of the centromeric regions has been reported to occur in G1 and S phase in different species. Here, we investigate whether transcription also…”
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Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types by Xu, Chundi, Ramos, Tyler B, Marshall, Owen J, Doe, Chris Q

“…Notch signaling is an evolutionarily conserved pathway for specifying binary neuronal fates, yet how it specifies different fates in different contexts remains…”
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Stem cell niche organization in the Drosophila ovary requires the ECM component Perlecan by Díaz-Torres, Alfonsa, Rosales-Nieves, Alicia E., Pearson, John R., Santa-Cruz Mateos, Carmen, Marín-Menguiano, Miriam, Marshall, Owen J., Brand, Andrea H., González-Reyes, Acaimo

“…Stem cells reside in specialized microenvironments or niches that balance stem cell proliferation and differentiation.1,2 The extracellular matrix (ECM) is an…”
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The Architecture and Evolution of Cancer Neochromosomes by Garsed, Dale W., Marshall, Owen J., Corbin, Vincent D.A., Hsu, Arthur, Di Stefano, Leon, Schröder, Jan, Li, Jason, Feng, Zhi-Ping, Kim, Bo W., Kowarsky, Mark, Lansdell, Ben, Brookwell, Ross, Myklebost, Ola, Meza-Zepeda, Leonardo, Holloway, Andrew J., Pedeutour, Florence, Choo, K.H. Andy, Damore, Michael A., Deans, Andrew J., Papenfuss, Anthony T., Thomas, David M.

“…We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes,…”
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A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation by Hatch, Hayden AM, Belalcazar, Helen M, Marshall, Owen J, Secombe, Julie

“…Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are associated with intellectual disability, yet little is known regarding…”
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Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition in Drosophila by Jefferies, Grace, Somers, Jason, Lohrey, Isabelle, Chaturvedi, Vishal, Calabria, Jacob, Marshall, Owen J, Southall, Tony D, Saint, Robert, Murray, Michael J

“…Epigenetic silencing by Polycomb group (PcG) complexes can promote epithelial-mesenchymal transition (EMT) and stemness and is associated with malignancy of…”
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Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin by Marshall, Owen J, Marshall, Alan T, Choo, K.H. Andy

“…The histone H3 variant centromere protein A (CENP-A) is central to centromere formation throughout eukaryotes. A long-standing question in centromere biology…”
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KDM5-mediated activation of genes required for mitochondrial biology is necessary for viability in Drosophila by Rogers, Michael F, Marshall, Owen J, Secombe, Julie

“…Histone-modifying proteins play important roles in the precise regulation of the transcriptional programs that coordinate development. KDM5 family proteins…”
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Profiling Protein-DNA Interactions Cell-Type-Specifically with Targeted DamID by Marshall, Owen J, Delandre, Caroline

“…Targeted DamID (TaDa) is a means of profiling the binding of any DNA-associated protein cell-type specifically, including transcription factors, RNA…”
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Cell-type-specific profiling of protein–DNA interactions without cell isolation using targeted DamID with next-generation sequencing by Marshall, Owen J, Southall, Tony D, Cheetham, Seth W, Brand, Andrea H

“…Targeted DamID (TaDa) extends DamID to enable cell-type-specific profiling of genome-wide protein binding. Transcription factor binding sites, RNA Pol II…”
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Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals by Doupé, David P., Marshall, Owen J., Dayton, Hannah, Brand, Andrea H., Perrimon, Norbert

“…Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that…”
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Understanding the impact of ZBTB18 missense variation on transcription factor function in neurodevelopment and disease by Heng, Julian I.‐T., Viti, Leon, Pugh, Kye, Marshall, Owen J., Agostino, Mark

“…Mutations to genes that encode DNA‐binding transcription factors (TFs) underlie a broad spectrum of human neurodevelopmental disorders. Here, we highlight the…”
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Neocentromeres come of age by Marshall, Owen J, Choo, K H Andy

“…  Whereas previously centromeres had been thought of as immovable and unchanging, embedded in vast tracts of tandemly repeated DNA, this new centromere--or…”
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Selective optogenetic inhibition of Gα q or Gα i signaling by minimal RGS domains disrupts circuit functionality and circuit formation by Lockyer, Jayde L, Reading, Andrew, Vicenzi, Silvia, Zbela, Agnieszka, Viswanathan, Saranya, Delandre, Caroline, Newland, Jake W, McMullen, John P D, Marshall, Owen J, Gasperini, Robert, Foa, Lisa, Lin, John Y

“…Optogenetic techniques provide genetically targeted, spatially and temporally precise approaches to correlate cellular activities and physiological outcomes…”
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Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4 by Gervais, Louis, van den Beek, Marius, Josserand, Manon, Sallé, Jérémy, Stefanutti, Marine, Perdigoto, Carolina N., Skorski, Patricia, Mazouni, Khallil, Marshall, Owen J., Brand, Andrea H., Schweisguth, François, Bardin, Allison J.

“…Chromatin remodeling accompanies differentiation, however, its role in self-renewal is less well understood. We report that in Drosophila, the chromatin…”
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Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution by Marshall, Owen J., Chueh, Anderly C., Wong, Lee H., Choo, K.H. Andy

“…Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic…”
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