Search Results - "Marshall, Mark S."

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms by King, Constance, Diaz, H Bruce, McNeely, Samuel, Barnard, Darlene, Dempsey, Jack, Blosser, Wayne, Beckmann, Richard, Barda, David, Marshall, Mark S

“…CHK1 is a multifunctional protein kinase integral to both the cellular response to DNA damage and control of the number of active replication forks. CHK1…”
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Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion by Damayanti, Nur P., Saadatzadeh, M. Reza, Dobrota, Erika, Ordaz, Josue D., Bailey, Barbara J., Pandya, Pankita H., Bijangi-Vishehsaraei, Khadijeh, Shannon, Harlan E., Alfonso, Anthony, Coy, Kathy, Trowbridge, Melissa, Sinn, Anthony L., Zhang, Zhong-Yin, Gallagher, Rosa I., Wulfkuhle, Julia, Petricoin, Emanuel, Richardson, Angela M., Marshall, Mark S., Lion, Alex, Ferguson, Michael J., Balsara, Karl E., Pollok, Karen E.

“…Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present…”
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Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Primary and Metastatic Pediatric and AYA Solid Tumors by Pandya, Pankita H, Jannu, Asha Jacob, Bijangi-Vishehsaraei, Khadijeh, Dobrota, Erika, Bailey, Barbara J, Barghi, Farinaz, Shannon, Harlan E, Riyahi, Niknam, Damayanti, Nur P, Young, Courtney, Malko, Rada, Justice, Ryli, Albright, Eric, Sandusky, George E, Wurtz, L Daniel, Collier, Christopher D, Marshall, Mark S, Gallagher, Rosa I, Wulfkuhle, Julia D, Petricoin, Emanuel F, Coy, Kathy, Trowbridge, Melissa, Sinn, Anthony L, Renbarger, Jamie L, Ferguson, Michael J, Huang, Kun, Zhang, Jie, Saadatzadeh, M Reza, Pollok, Karen E

“…Establishment of clinically annotated, molecularly characterized, patient-derived xenografts (PDXs) from treatment-naïve and pretreated patients provides a…”
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PAK1 Phosphorylation of MEK1 Regulates Fibronectin-Stimulated MAPK Activation by Slack-Davis, Jill K., Eblen, Scott T., Zecevic, Maja, Boerner, Scott A., Tarcsafalvi, Adel, Diaz, H. Bruce, Marshall, Mark S., Weber, Michael J., Parsons, J. Thomas, Catling, Andrew D.

“…Activation of the Ras-MAPK signal transduction pathway is necessary for biological responses both to growth factors and ECM. Here, we provide evidence that…”
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Targeted treatment of refractory primitive neuroectodermal tumor arising from an immature teratoma with crizotinib leading to a sustained response by Snyder, Benjamin M., Lion, Alex H., Helvie, Amy E., Marshall, Mark S., Ferguson, Michael J.

“…Here we present a case of metastatic PNET which arose from an immature teratoma that was refractory to standard Ewing sarcoma chemotherapy. This PNET was…”
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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 by Marshall, Mark S, King, Alastair J, Sun, Huaiyu, Diaz, Bruce, Barnard, Darlene, Miao, Wenyan, Bagrodia, Shubha

“…The pathway involving the signalling protein p21Ras propagates a range of extracellular signals from receptors on the cell membrane to the cytoplasm and…”
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Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-κB pathway in pancreatic carcinoma cells by Yip-Schneider, Michele T, Nakshatri, Harikrishna, Sweeney, Christopher J, Marshall, Mark S, Wiebke, Eric A, Schmidt, C Max

“…Activation of the transcription factor nuclear factor-κB (NF-κB) has been implicated in pancreatic tumorigenesis. We evaluated the effect of a novel NF-κB…”
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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy by Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M

“…Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression…”
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Previously unreported somatic variants in two patients with pleuropulmonary blastoma with metastatic brain recurrence by Ferguson, Michael J., Ivanovich, Jennifer, Stansell, Paige, Vik, Terry A., Helvie, Amy E., Schmitt, Morgan R., Schultz, Kris Ann, Dehner, Louis P., Renbarger, Jamie L., Marshall, Mark S.

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Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma by Pandya, Pankita H., Cheng, Lijun, Saadatzadeh, M. Reza, Bijangi-Vishehsaraei, Khadijeh, Tang, Shan, Sinn, Anthony L., Trowbridge, Melissa A., Coy, Kathryn L., Bailey, Barbara J., Young, Courtney N., Ding, Jixin, Dobrota, Erika A., Dyer, Savannah, Elmi, Adily, Thompson, Quinton, Barghi, Farinaz, Shultz, Jeremiah, Albright, Eric A., Shannon, Harlan E., Murray, Mary E., Marshall, Mark S., Ferguson, Michael J., Bertrand, Todd E., Wurtz, L. Daniel, Batra, Sandeep, Li, Lang, Renbarger, Jamie L., Pollok, Karen E.

“…Osteosarcoma (OS) patients exhibit poor overall survival, partly due to copy number variations (CNVs) resulting in dysregulated gene expression and therapeutic…”
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Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase by Hurley, Joyce H, Zhang, Shengwen, Bye, Leighan S, Marshall, Mark S, DePaoli-Roach, Anna A, Guan, Kunliang, Fox, Aaron P, Yu, Lei

“…G protein-coupled receptors (GPCRs) interact with heterotrimeric GTP-binding proteins (G proteins) to modulate acute changes in intracellular messenger levels…”
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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak by Sun, Huaiyu, King, Alastair J., Diaz, H.Bruce, Marshall, Mark S.

“…Activation of the protein kinase Raf-1 is a complex process involving association with the GTP-bound form of Ras (Ras–GTP), membrane translocation and both…”
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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 by XIAN-FENG ZHANG, SETTLEMAN, J, KYRIAKIS, J. M, TAKEUCHI-SUZUKI, E, ELLEDGE, S. J, MARSHALL, M. S, BRUDER, J. T, RAPP, U. R, AVRUCH, J

“…In higher eukaryotes, the Ras and Raf-1 proto-oncoproteins transduce growth and differentiation signals initiated by tyrosine kinases. The Ras polypeptide and…”
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells by Yip-Schneider, M T, Sweeney, C J, Jung, S H, Crowell, P L, Marshall, M S

“…Increased cyclooxygenase-2 (COX-2) expression in human pancreatic adenocarcinomas, as well as the growth-inhibitory effect of nonsteroidal anti-inflammatory…”
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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ by Luo, Zhijun, Diaz, Bruce, Marshall, Mark S., Avruch, Joseph

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Retraction: Interferon-inducible protein 10 and macrophage inflammatory protein-1α inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. VOLUME 270 (1995) PAGES 21998-22007 by Aronica, Susan M., Mantel, Charlie, Gonin, Rene, Marshall, Mark S., Sarris, Andreas, Cooper, Scott, Hague, Nancy, Zhang, Xian-Feng, Broxmeyer, Hal E.

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Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2 by Gelfanov, Vasily M., Burgess, Gem S., Litz-Jackson, Sara, King, Alastair J., Marshall, Mark S., Nakshatri, Harikrishna, Boswell, H. Scott

“…Tyrosine kinase oncogenes such as p210BCR-ABL activate multiple signal pathways. As a result, it is difficult to infer the functional relevance of a pathway…”
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BIOM-10. EXAMINATION OF GROWTH DIFFERENTIATION FACTOR 15 (GDF15) EXPRESSION AS A POTENTIAL PROGNOSTIC BIOMARKER IN PEDIATRIC BRAIN TUMORS by Marlowe, Elizabeth, Ferguson, Michael J, Marshall, Mark S, Runco, Daniel V

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PDGF induction of tyrosine phosphorylation of GTPase activating protein by Molloy, Christopher J, Bottaro, Donald P, Fleming, Timothy P, Marshall, Mark S, Gibbs, Jackson B, Aaronson, Stuart A

“…The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion…”
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Cloning of bovine GAP and its interaction with oncogenic ras p21 by Vogel, Ursula S, Dixon, Richard A. F, Schaber, Michael D, Diehl, Ronald E, Marshall, Mark S, Scolnick, Edward M, Sigal, Irving S, Gibbs, Jackson B

“…The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine…”
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