Search Results - "Marshall, Jean S."

An introduction to immunology and immunopathology by Marshall, Jean S, Warrington, Richard, Watson, Wade, Kim, Harold L

“…Beyond structural and chemical barriers to pathogens, the immune system has two fundamental lines of defense: innate immunity and adaptive immunity. Innate…”
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Mast Cell Responses to Viruses and Pathogen Products by Marshall, Jean S, Portales-Cervantes, Liliana, Leong, Edwin

“…Mast cells are well accepted as important sentinel cells for host defence against selected pathogens. Their location at mucosal surfaces and ability to…”
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Cytokines and Soluble Receptors in Breast Milk as Enhancers of Oral Tolerance Development by Dawod, Bassel, Marshall, Jean S

“…The postpartum period is an important window during which environmental factors can shape the life-long health of the infant. This time period often coincides…”
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Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention by Leong, Edwin, Bezuhly, Michael, Marshall, Jean S.

“…Systemic sclerosis (SSc) is a chronic debilitating idiopathic disorder, characterized by deposition of excessive extracellular matrix (ECM) proteins such as…”
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Ketotifen directly modifies the fibrotic response of human skin fibroblasts by Leong, Edwin, Al-Bitar, Haya, Marshall, Jean S., Bezuhly, Michael

“…Fibrosis is a destructive, end-stage disease process. In the skin, it is associated with systemic sclerosis and scarring with considerable health burden…”
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Mast Cells in Cardiac Fibrosis: New Insights Suggest Opportunities for Intervention by Legere, Stephanie A, Haidl, Ian D, Légaré, Jean-François, Marshall, Jean S

“…Mast cells (MC) are innate immune cells present in virtually all body tissues with key roles in allergic disease and host defense. MCs recognize…”
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Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence by Palma, Alejandro M, Hanes, Mark R, Marshall, Jean S

“…Mast cells are well known to be activated cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and…”
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Novel inflammatory mediator profile observed during pediatric heart surgery with cardiopulmonary bypass and continuous ultrafiltration by Bierer, Joel, Stanzel, Roger, Henderson, Mark, Sett, Suvro, Sapp, John, Andreou, Pantelis, Marshall, Jean S, Horne, David

“…Cardiopulmonary bypass (CPB) is associated with systemic inflammation, featuring increased levels of circulating pro-inflammatory cytokines. Intra-operative…”
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Mast Cells and Natural Killer Cells-A Potentially Critical Interaction by Portales-Cervantes, Liliana, Dawod, Bassel, Marshall, Jean S

“…Natural killer (NK) cells play critical roles in host defense against infectious agents or neoplastic cells. NK cells provide a rapid innate immune response…”
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Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects by Meghnem, Dihia, Oldford, Sharon A., Haidl, Ian D., Barrett, Lisa, Marshall, Jean S.

“…Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal…”
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Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis by Alrashdi, Barakat, Dawod, Bassel, Schampel, Andrea, Tacke, Sabine, Kuerten, Stefanie, Marshall, Jean S, Côté, Patrice D

“…In multiple sclerosis (MS) and in the experimental autoimmune encephalomyelitis (EAE) model of MS, the Nav1.6 voltage-gated sodium (Nav) channel isoform has…”
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Mast cells selectively produce inflammatory mediators and impact the early response to Chlamydia reproductive tract infection by Mayavannan, Animamalar, Shantz, Emily, Haidl, Ian D, Wang, Jun, Marshall, Jean S

“…( ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor…”
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High-exchange ULTrafiltration to enhance recovery after paediatric cardiac surgery (ULTRA): study protocol for a Canadian double-blinded randomised controlled trial by Bierer, Joel, Stanzel, Roger, Henderson, Mark, Krmpotic, Kristina, Andreou, Pantelis, Marshall, Jean S., Sapp, John, Horne, David

“…IntroductionSurgical repair is the standard of care for most infants and children with congenital heart disease. Cardiopulmonary bypass (CPB) is required to…”
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Differences in IDO1 + dendritic cells and soluble CTLA-4 are associated with differential clinical responses to methotrexate treatment in rheumatoid arthritis by Malik, Anikó E, Slauenwhite, Drew, McAlpine, Sarah M, Hanly, John G, Marshall, Jean S, Issekutz, Thomas B

“…Antigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential…”
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Respiratory syncytial virus infection of primary human mast cells induces the selective production of type I interferons, CXCL10, and CCL4 by Al-Afif, Ayham, MSc, Alyazidi, Raidan, MD, Oldford, Sharon A., PhD, Huang, Yan Y., PhD, King, Christine A., PhD, Marr, Nico, PhD, Haidl, Ian D., PhD, Anderson, Robert, PhD, Marshall, Jean S., PhD

“…Background Respiratory syncytial virus (RSV) causes severe respiratory tract infections, which might have a role in the development of airway hyperreactivity…”
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A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth by Oldford, Sharon A, Haidl, Ian D, Howatt, Mackenzie A, Leiva, Carlos A, Johnston, Brent, Marshall, Jean S

“…Several TLR agonists are effective in tumor immunotherapy, but their early innate mechanisms of action, particularly those of TLR2 agonists, are unclear. Mast…”
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Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro by Gotovina, Jelena, Bianchini, Rodolfo, Fazekas‐Singer, Judit, Herrmann, Ina, Pellizzari, Giulia, Haidl, Ian D., Hufnagl, Karin, Karagiannis, Sophia N., Marshall, Jean S., Jensen‐Jarolim, Erika

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Prenatal exposure to phthalates, bisphenol A and perfluoroalkyl substances and cord blood levels of IgE, TSLP and IL-33 by Ashley-Martin, Jillian, Dodds, Linda, Levy, Adrian R., Platt, Robert W., Marshall, Jean S., Arbuckle, Tye E.

“…The fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental…”
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Mast Cells and Skin and Breast Cancers: A Complicated and Microenvironment-Dependent Role by Hanes, Mark R, Giacomantonio, Carman A, Marshall, Jean S

“…Mast cells are important sentinel cells in host defense against infection and major effector cells in allergic disease. The role of these cells in cancer…”
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Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge by Alrashdi, Barakat, Dawod, Bassel, Tacke, Sabine, Kuerten, Stefanie, Côté, Patrice D, Marshall, Jean S

“…Voltage gated sodium (Nav) channels contribute to axonal damage following demyelination in experimental autoimmune encephalomyelitis (EAE), a rodent model of…”
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