Search Results - "Marsh, Stephen J."

Regulation of M(Kv7.2/7.3) channels in neurons by PIP2 and products of PIP2 hydrolysis: significance for receptor-mediated inhibition by Brown, David A., Hughes, Simon A., Marsh, Stephen J., Tinker, Andrew

“…M-channels are voltage-gated K+ channels that regulate the excitability of many neurons. They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 +…”
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Relationship between Membrane Phosphatidylinositol-4,5-Bisphosphate and Receptor-Mediated Inhibition of Native Neuronal M Channels by Winks, Joanna S, Hughes, Simon, Filippov, Alexander K, Tatulian, Lucine, Abogadie, Fe C, Brown, David A, Marsh, Stephen J

“…The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in…”
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KCNQ/M Currents in Sensory Neurons: Significance for Pain Therapy by Passmore, Gayle M, Selyanko, Alexander A, Mistry, Mohini, Al-Qatari, Mona, Marsh, Stephen J, Matthews, Elizabeth A, Dickenson, Anthony H, Brown, Terry A, Burbidge, Stephen A, Main, Martin, Brown, David A

“…Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [IK(M)] play a key role in regulating neuronal…”
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Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings by Passmore, Gayle M, Reilly, Joanne M, Thakur, Matthew, Keasberry, Vanessa N, Marsh, Stephen J, Dickenson, Anthony H, Brown, David A

“…M-channels carry slowly activating potassium currents that regulate excitability in a variety of central and peripheral neurons. Functional M-channels and…”
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Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors by Filippov, Alexander K, Fernández-Fernández, Jose M, Marsh, Stephen J, Simon, Joseph, Barnard, Eric A, Brown, David A

“…Neuronal signaling by G protein-coupled P2Y nucleotide receptors is not well characterized. We studied here the coupling of different molecularly defined P2Y…”
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Effects of serum immunoglobulins from patients with complex regional pain syndrome (CRPS) on depolarisation-induced calcium transients in isolated dorsal root ganglion (DRG) neurons by Reilly, Joanne M., Dharmalingam, Backialakshmi, Marsh, Stephen J., Thompson, Victoria, Goebel, Andreas, Brown, David A.

“…Complex regional pain syndrome (CRPS) is thought to have an auto-immune component. One such target recently proposed from the effects of auto-immune IgGs on…”
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Probing the Regulation of M (Kv7) Potassium Channels in Intact Neurons with Membrane-Targeted Peptides by Robbins, Jon, Marsh, Stephen J, Brown, David A

“…M-type (Kv7) potassium channels are closed by Gq/11 G-protein-coupled receptors. Several membrane- or channel-associated molecules have been suggested to…”
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Kv7/M-type potassium channels in rat skin keratinocytes by Reilly, Joanne M., Telezhkin, Vsevolod, Passmore, Gayle M., Marsh, Stephen J., Brown, David A.

“…Skin keratinocytes fulfil important signalling and protective functions. Immunocytochemical experiments revealed the unexpected presence of immunoreactivity…”
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PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons by Hughes, Simon, Marsh, Stephen J, Tinker, Andrew, Brown, David A

“…The open state of M(Kv7.2/7.3) potassium channels is maintained by membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)). They can be closed on…”
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PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons by Hughes, Simon, Marsh, Stephen J., Tinker, Andrew, Brown, David A.

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Muscarinic M1 receptors activate phosphoinositide turnover and Ca2+ mobilisation in rat sympathetic neurones, but this signalling pathway does not mediate M-current inhibition by del Río, E, Bevilacqua, J A, Marsh, S J, Halley, P, Caulfield, M P

“…The relationship between muscarinic receptor activation, phosphoinositide turnover, calcium mobilisation and M-current inhibition has been studied in rat…”
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Inhibition of the antigen-induced activation of RBL-2H3 cells by charybdotoxin and cetiedil by Narenjkar, Jamshid, Marsh, Stephen J., Assem, El-Sayed K.

“…Quinidine and Ba 2+, non-selective K +-channel blockers, have previously been shown to inhibit antigen-induced mediator (β-hexosaminidase) release from RBL-2H3…”
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PIP sub(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP sub(2) depletion by Gq-coupled receptors in single living neurons by Hughes, Simon, Marsh, Stephen J, Tinker, Andrew, Brown, David A

“…The open state of M(Kv7.2/7.3) potassium channels is maintained by membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P sub(2)). They can be closed on…”
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PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons by Hughes, Simon, Marsh, Stephen J, Tinker, Andrew, Brown, David A

“…The open state of M(Kv7.2/7.3) potassium channels is maintained by membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2). They can be closed on…”
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Stimulation of Gαq-coupled M1 muscarinic receptor causes reversible spectrin redistribution mediated by PLC, PKC and ROCK by Street, Miyoko, Marsh, Stephen J., Stabach, Paul R., Morrow, Jon S., Brown, David A., Buckley, Noel J.

“…Spectrin is a cytoskeletal protein that plays a role in formation of the specialized plasma membrane domains. However, little is known of the molecular…”
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Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition by Brown, David A, Hughes, Simon A, Marsh, Stephen J, Tinker, Andrew

“…M-channels are voltage-gated K+ channels that regulate the excitability of many neurons. They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 +…”
Get full text

Regulation of M(Kv7.2-7.3) channels in neurons by PIP sub(2) and products of PIP sub(2) hydrolysis: significance for receptor-mediated inhibition by Brown, David A, Hughes, Simon A, Marsh, Stephen J, Tinker, Andrew

“…M-channels are voltage-gated K+ channels that regulate the excitability of many neurons. They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 +…”
Get full text

Regulation of M(Kv7.2/7.3) channels in neurons by PIP 2 and products of PIP 2 hydrolysis: significance for receptor‐mediated inhibition by Brown, David A., Hughes, Simon A., Marsh, Stephen J., Tinker, Andrew

“…M‐channels are voltage‐gated K+ channels that regulate the excitability of many neurons. They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 +…”
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Stimulation of Galphaq-coupled M1 muscarinic receptor causes reversible spectrin redistribution mediated by PLC, PKC and ROCK by Street, Miyoko, Marsh, Stephen J, Stabach, Paul R, Morrow, Jon S, Brown, David A, Buckley, Noel J

“…Spectrin is a cytoskeletal protein that plays a role in formation of the specialized plasma membrane domains. However, little is known of the molecular…”
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Elevation of Intracellular Calcium by Muscarinic Receptor Activation Induces a Block of Voltage-Activated Rat ether-à-go-go Channels in a Stably Transfected Cell Line by Stansfeld, Catherine E., Röper, Jochen, Ludwig, Jost, Weseloh, Rüdiger M., Marsh, Stephen J., Brown, David A., Pongs, Olaf

“…We have studied the properties of r-eag voltage-activated potassium channels in a stably transfected human embryonic kidney cell line. It was found that r-eag…”
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