Search Results - "Marsh, JL"

Mechanical supports for acute, severe ankle sprain: a pragmatic, multicentre, randomised controlled trial by Lamb, SE, Prof, Marsh, JL, PhD, Hutton, JL, Prof, Nakash, R, PhD, Cooke, MW, Prof

“…Summary Background Severe ankle sprains are a common presentation in emergency departments in the UK. We aimed to assess the effectiveness of three different…”
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Commentary on “Classification of Bone Defects: An Extension of the Orthopaedic Trauma Association Open Fracture Classification” by Marsh, J. Lawrence

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Clinical and cost effectiveness of mechanical support for severe ankle sprains: design of a randomised controlled trial in the emergency department [ISRCTN 37807450] by Lamb, S E, Nakash, R A, Withers, E J, Clark, M, Marsh, J L, Wilson, S, Hutton, J L, Szczepura, A, Dale, J R, Cooke, M W

“…The optimal management for severe sprains (Grades II and III) of the lateral ligament complex of the ankle is unclear. The aims of this randomised controlled…”
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Supracondylar Fractures of the Femur Treated by External Fixation by Marsh, J L, Jansen, Hendrik, Yoong, H K, Found, Ernest M

“…OBJECTIVE:To determine the results and complications of treating supracondylar fractures of the femur with external fixation. DESIGN:Retrospective follow-up…”
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A Potent Small Molecule Inhibits Polyglutamine Aggregation in Huntington's Disease Neurons and Suppresses Neurodegeneration in vivo by Zhang, Xiaoqian, Smith, Donna L., Meriin, Anatoli B., Engemann, Sabine, Russel, Deborah E., Roark, Margo, Washington, Shetia L., Maxwell, Michele M., Marsh, J. Lawrence, Thompson, Leslie Michels, Wanker, Erich E., Young, Anne B., Housman, David E., Bates, Gillian P., Sherman, Michael Y., Kazantsev, Aleksey G.

“…Polyglutamine (polyQ) disorders, including Huntington's disease (HD), are caused by expansion of polyQ-encoding repeats within otherwise unrelated gene…”
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SUMO Modification of Huntingtin and Huntington'S Disease Pathology by Steffan, Joan S., Agrawal, Namita, Pallos, Judit, Rockabrand, Erica, Trotman, Lloyd C., Slepko, Natalia, Illes, Katalin, Lukacsovich, Tamas, Zhu, Ya-Zhen, Cattaneo, Elena, Pandolfi, Pier Paolo, Thompson, Leslie Michels, Marsh, J. Lawrence

“…Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein, Huntingtin (Htt), that contains an abnormal polyglutamine expansion…”
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High-Energy Fractures of the Tibial Plateau: Knee Function After Longer Follow-up by Weigel, Dennis P, Marsh, J Lawrence

“…BackgroundStudies of the long-term outcomes of treatment of fractures of the tibial plateau have included wide mixtures of fracture types and mostly low-energy…”
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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila by Thompson, Leslie M, Steffan, Joan S, Bodai, Laszlo, Pallos, Judit, Poelman, Marnix, McCampbell, Alexander, Apostol, Barbara L, Kazantsev, Alexsey, Schmidt, Emily, Zhu, Ya-Zhen, Greenwald, Marilee, Kurokawa, Riki, Housman, David E, Jackson, George R, Marsh, J. Lawrence

“…Proteins with expanded polyglutamine repeats cause Huntington's disease and other neurodegenerative diseases. Transcriptional dysregulation and loss of…”
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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease by Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, Sathasivam, Kirupa, Ghazi-Noori, Shabnam, Mahal, Amarbirpal, Philip A. S. Lowden, Steffan, Joan S., Marsh, J. Lawrence, Thompson, Leslie M., Lewis, Cathryn M., Marks, Paul A., Bates, Gillian P.

“…Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no…”
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The HSPGs Syndecan and Dallylike Bind the Receptor Phosphatase LAR and Exert Distinct Effects on Synaptic Development by Johnson, Karl G., Tenney, Alan P., Ghose, Aurnab, Duckworth, April M., Higashi, Misao E., Parfitt, Karen, Marcu, Oana, Heslip, Timothy R., Marsh, J. Lawrence, Schwarz, Thomas L., Flanagan, John G., Van Vactor, David

“…The formation and plasticity of synaptic connections rely on regulatory interactions between pre- and postsynaptic cells. We show that the Drosophila heparan…”
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Articular Fractures: Does an Anatomic Reduction Really Change the Result? by Marsh, J L, Buckwalter, J, Gelberman, R, Dirschl, D, Olson, S, Brown, T, Llinias, A

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Speech, cognitive, and behavioral outcomes in nonsyndromic craniosynostosis by BECKER, Devra B, PETERSEN, Jason D, KANE, Alex A, CRADOCK, Mary Michaeleen, PILGRAM, Thomas K, MARSH, Jeffrey L

“…The neuropsychological morbidity of nonsyndromic craniosynostosis is incompletely understood. The purpose of this study was to establish the prevalence of…”
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Tibial Plafond Fractures : How Do These Ankles Function Over Time? by Marsh, J Lawrence, Weigel, Dennis P, Dirschl, Douglas R

“…BackgroundThe intermediate outcome of fractures of the tibial plafond treated with current techniques has not been reported, to our knowledge. The purpose of…”
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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity by Apostol, Barbara L., Illes, Katalin, Pallos, Judit, Bodai, Laszlo, Wu, Jun, Strand, Andrew, Schweitzer, Erik S., Olson, James M., Kazantsev, Aleksey, Marsh, J. Lawrence, Thompson, Leslie Michels

“…Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract within the huntingtin protein (Htt)…”
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Suppression of Huntington's Disease Pathology in Drosophila by Human Single-Chain Fv Antibodies by Wolfgang, William J., Miller, Todd W., Webster, Jack M., Huston, James S., Thompson, Leslie M., Marsh, J. Lawrence, Messer, Anne, Ingram, Vernon Martin

“…Misfolded neuronal proteins have been identified in a number of neurodegenerative disorders and have been implicated in the pathogenesis of diseases that…”
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Formation of the BMP Activity Gradient in the Drosophila Embryo by Mizutani, Claudia Mieko, Nie, Qing, Wan, Frederic Y.M., Zhang, Yong-Tao, Vilmos, Peter, Sousa-Neves, Rui, Bier, Ethan, Marsh, J. Lawrence, Lander, Arthur D.

“…The dorsoventral axis of the Drosophila embryo is patterned by a gradient of bone morphogenetic protein (BMP) ligands. In a process requiring at least three…”
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Identification of Combinatorial Drug Regimens for Treatment of Huntington's Disease Using Drosophila by Agrawal, Namita, Pallos, Judit, Slepko, Natalia, Apostol, Barbara L., Bodai, Laszlo, Chang, Ling-Wen, Chiang, Ann-Shyn, Thompson, Leslie Michels, Marsh, J. Lawrence, Housman, David E.

“…We explore the hypothesis that pathology of Huntington's disease involves multiple cellular mechanisms whose contributions to disease are incrementally…”
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Can flies help humans treat neurodegenerative diseases? by Marsh, J. Lawrence, Thompson, Leslie Michels

“…Neurodegenerative diseases are becoming increasingly common as life expectancy increases. Recent years have seen tremendous progress in the identification of…”
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A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor by Pollitt, Sonia K, Pallos, Judit, Shao, Jieya, Desai, Urvee A, Ma, Aye Aye K, Thompson, Leslie Michels, Marsh, J.Lawrence, Diamond, Marc I

“…Many neurodegenerative diseases, including tauopathies, Parkinson's disease, amyotrophic lateral sclerosis, and the polyglutamine diseases, are characterized…”
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Twisted gastrulation is a conserved extracellular BMP antagonist by O'Connor, Michael B, Marsh, J. Lawrence, Ross, Jeffrey J, Shimmi, Osamu, Vilmos, Peter, Petryk, Anna, Kim, Hyon, Gaudenz, Karin, Hermanson, Spencer, Ekker, Stephen C

“…Bone morphogenetic protein (BMP) signalling regulates embryonic dorsal-ventral cell fate decisions in flies, frogs and fish. BMP activity is controlled by…”
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