Search Results - "Marsh, C. L."

Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling by Kurian, S. M., Williams, A. N., Gelbart, T., Campbell, D., Mondala, T. S., Head, S. R., Horvath, S., Gaber, L., Thompson, R., Whisenant, T., Lin, W., Langfelder, P., Robison, E. H., Schaffer, R. L., Fisher, J. S., Friedewald, J., Flechner, S. M., Chan, L. K., Wiseman, A. C., Shidban, H., Mendez, R., Heilman, R., Abecassis, M. M., Marsh, C. L., Salomon, D. R.

“…There are no minimally invasive diagnostic metrics for acute kidney transplant rejection (AR), especially in the setting of the common confounding diagnosis,…”
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Challenges to Research and Innovation to Optimize Deceased Donor Organ Quality and Quantity by Abt, P. L., Marsh, C. L., Dunn, T. B., Hewitt, W. R., Rodrigue, J. R., Ham, J. M., Feng, S.

“…Solid organ transplantation is encumbered by an increasing number of waitlisted patients unrequited by the current organ supply. Preclinical models suggest…”
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Quantifying the Risk of Incompatible Kidney Transplantation: A Multicenter Study by Orandi, B. J., Garonzik‐Wang, J. M., Massie, A. B., Zachary, A. A., Montgomery, J. R., Van Arendonk, K. J., Stegall, M. D., Jordan, S. C., Oberholzer, J., Dunn, T. B., Ratner, L. E., Kapur, S., Pelletier, R. P., Roberts, J. P., Melcher, M. L., Singh, P., Sudan, D. L., Posner, M. P., El‐Amm, J. M., Shapiro, R., Cooper, M., Lipkowitz, G. S., Rees, M. A., Marsh, C. L., Sankari, B. R., Gerber, D. A., Nelson, P. W., Wellen, J., Bozorgzadeh, A., Gaber, A. O., Montgomery, R. A., Segev, D. L.

“…Incompatible live donor kidney transplantation (ILDKT) offers a survival advantage over dialysis to patients with anti‐HLA donor‐specific antibody (DSA)…”
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Realising resource efficiency in the management of healthcare waste from the Cornwall National Health Service (NHS) in the UK by Tudor, T.L., Marsh, C.L., Butler, S., Van Horn, J.A., Jenkin, L.E.T.

“…The quantities of waste generated by the healthcare sector in the United Kingdom (UK) have been shown to be amongst the highest in Europe. Based on a case…”
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Inhibitory effects of immunosuppressive drugs on insulin secretion from HIT-T15 cells and wistar rat islets by PATY, B. W, HARMON, J. S, MARSH, C. L, ROBERTSON, R. P

“…Until recently, islet allotransplantation for type 1 diabetic patients has been largely unsuccessful. Previous pharmacologic studies of single drugs have…”
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The Current State of Liver Transplantation in the United States: Perspective From American Society of Transplant Surgeons (ASTS) Scientific Studies Committee and Endorsed by ASTS Council by Fayek, S A, Quintini, C, Chavin, K D, Marsh, C L

“…This article is a review of the salient points and a future prospective based on the 2014 Organ Procurement and Transplantation Network (OPTN)/Scientific…”
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Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long‐Term Outcomes by Modena, B. D., Kurian, S. M., Gaber, L. W., Waalen, J., Su, A. I., Gelbart, T., Mondala, T. S., Head, S. R., Papp, S., Heilman, R., Friedewald, J. J., Flechner, S. M., Marsh, C. L., Sung, R. S., Shidban, H., Chan, L., Abecassis, M. M., Salomon, D. R.

“…Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1‐year biopsies posttransplant. It is known that IFTA correlates with…”
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Kidney Exchange to Overcome Financial Barriers to Kidney Transplantation by Rees, M. A., Dunn, T. B., Kuhr, C. S., Marsh, C. L., Rogers, J., Rees, S. E., Cicero, A., Reece, L. J., Roth, A. E., Ekwenna, O., Fumo, D. E., Krawiec, K. D., Kopke, J. E., Jain, S., Tan, M., Paloyo, S. R.

“…Organ shortage is the major limitation to kidney transplantation in the developed world. Conversely, millions of patients in the developing world with…”
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Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients by Thummel, K E, Shen, D D, Podoll, T D, Kunze, K L, Trager, W F, Hartwell, P S, Raisys, V A, Marsh, C L, McVicar, J P, Barr, D M

“…The clearance of midazolam (MDZ) in humans is principally due to metabolic biotransformation catalyzed by CYP3A isoforms. A study was conducted in patients who…”
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Long-term cognitive and psychiatric outcomes of acute respiratory distress syndrome managed with Extracorporeal Membrane Oxygenation by Marsh, L.C., Leach, R.M., Blane, J., Daly, K., Barrett, N.A., Slack, A., Kopelman, M.D.

“…Cognitive dysfunction is often reported in patients who have experienced acute respiratory distress syndrome (ARDS). Extra Corporeal Membrane Oxygenation…”
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First-pass metabolism of midazolam by the human intestine by Paine, M F, Shen, D D, Kunze, K L, Perkins, J D, Marsh, C L, McVicar, J P, Barr, D M, Gillies, B S, Thummel, K E

“…The in vivo intestinal metabolism of the CYP3A probe midazolam to its principal metabolite, 1'-hydroxymidazolam, was investigated during surgery in 10 liver…”
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Ureteral Complications in Renal Transplantation: A Comparison of the Lich-Gregoir Versus the Taguchi Technique by Lee, R.S, Bakthavatsalam, R, Marsh, C.L, Kuhr, C.S

“…Abstract Objective Modifications of the Lich-Gregoir extravesical ureteroneocystostomy have become the standard technique for management of the ureter during…”
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Global kidney exchange: Financially incompatible pairs are not transplantable compatible pairs by Rees, M. A., Paloyo, S. R., Roth, A. E., Krawiec, K. D., Ekwenna, O., Marsh, C. L., Wenig, A. J., Dunn, T. B.

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Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation by Thummel, K E, Shen, D D, Podoll, T D, Kunze, K L, Trager, W F, Bacchi, C E, Marsh, C L, McVicar, J P, Barr, D M, Perkins, J D

“…Immunosuppression therapy with cyclosporine is often hampered by significant interindividual variability in the metabolic clearance of the drug. It has been…”
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Application of TruGraf v1: A Novel Molecular Biomarker for Managing Kidney Transplant Recipients With Stable Renal Function by Marsh, C.L., Kurian, S.M., Rice, J.C., Whisenant, T.C., David, J., Rose, S., Schieve, C., Lee, D., Case, J., Barrick, B., Peddi, V.R., Mannon, R.B., Knight, R., Maluf, D., Mandelbrot, D., Patel, A., Friedewald, J.J., Abecassis, M.M., First, M.R.

“…TruGraf v1 is a laboratory-developed DNA microarray-based gene expression blood test to enable proactive noninvasive serial assessment of kidney transplant…”
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The Current State of Liver Transplantation in the United States by Fayek, S. A., Quintini, C., Chavin, K. D., Marsh, C. L.

“…This article is a review of the salient points and a future prospective based on the 2014 Organ Procurement and Transplantation Network (OPTN)/Scientific…”
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The Incremental Cost of Incompatible Living Donor Kidney Transplantation: A National Cohort Analysis by Axelrod, D., Lentine, K. L., Schnitzler, M. A., Luo, X., Xiao, H., Orandi, B. J., Massie, A., Garonzik‐Wang, J., Stegall, M. D., Jordan, S. C., Oberholzer, J., Dunn, T. B., Ratner, L. E., Kapur, S., Pelletier, R. P., Roberts, J. P., Melcher, M. L., Singh, P., Sudan, D. L., Posner, M. P., El‐Amm, J. M., Shapiro, R., Cooper, M., Lipkowitz, G. S., Rees, M. A., Marsh, C. L., Sankari, B. R., Gerber, D. A., Nelson, P. W., Wellen, J., Bozorgzadeh, A., Osama Gaber, A., Montgomery, R. A., Segev, D. L.

“…Incompatible living donor kidney transplantation (ILDKT) has been established as an effective option for end‐stage renal disease patients with willing but…”
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Investigator Assessment of the Utility of the TruGraf Molecular Diagnostic Test in Clinical Practice by First, M.R., Peddi, V.R., Mannon, R., Knight, R., Marsh, C.L., Kurian, S.M., Rice, J.C., Maluf, D., Mandelbrot, D., Patel, A., David, J., Schieve, C., Lee, D., Lewis, P., Friedewald, J.J., Abecassis, M.M., Rose, S.

“…TruGraf v1 is a well-validated DNA microarray-based test that analyzes blood gene expression profiles as an indicator of immune status in kidney transplant…”
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Effects of Rifampin on Tacrolimus Pharmacokinetics in Healthy Volunteers by Hebert, Mary F., Fisher, Richard M., Marsh, Christopher L., Dressler, Dawna, Bekersky, Ihor

“…Tacrolimus is a marketed immunosuppressant used in liver and kidney transplantation. It is subject to extensive metabolism by CYP3A4 and is a substrate for…”
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Low Dose Rate Irradiation Facility: initial study on chronic exposures to medaka by Hinton, T.G, Coughlin, D.P, Yi, Yi, Marsh, L.C

“…Uncertainties associated with the effects from chronic low-level exposures to radiation prompted us to construct a Low Dose Rate Irradiation Facility (LoDIF)…”
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