Search Results - "Marselli, L"

Autophagy in human type 2 diabetes pancreatic beta cells by Masini, M, Bugliani, M, Lupi, R, del Guerra, S, Boggi, U, Filipponi, F, Marselli, L, Masiello, P, Marchetti, P

“…Aims/hypothesis Beta cell loss contributes to type 2 diabetes, with increased apoptosis representing an underlying mechanism. Autophagy, i.e. the physiological…”
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Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes by Bugliani, M, Mossuto, S, Grano, F, Suleiman, M, Marselli, L, Boggi, U, De Simone, P, Eizirik, D L, Cnop, M, Marchetti, P, De Tata, V

“…Autophagy is the major mechanism involved in degradation and recycling of intracellular components, and its alterations have been proposed to cause beta cell…”
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endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients by Marchetti, P, Bugliani, M, Lupi, R, Marselli, L, Masini, M, Boggi, U, Filipponi, F, Weir, G. C, Eizirik, D. L, Cnop, M

“…Aims/hypothesis Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been…”
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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets by Marchetti, P., Lupi, R., Bugliani, M., Kirkpatrick, C. L., Sebastiani, G., Grieco, F. A., Del Guerra, S., D’Aleo, V., Piro, S., Marselli, L., Boggi, U., Filipponi, F., Tinti, L., Salvini, L., Wollheim, C. B., Purrello, F., Dotta, F.

“…Aims/hypothesis Glucagon-like peptide 1 (GLP-1) is a major incretin, mainly produced by the intestinal L cells, with beneficial actions on pancreatic beta…”
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C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells by Allagnat, F, Fukaya, M, Nogueira, T C, Delaroche, D, Welsh, N, Marselli, L, Marchetti, P, Haefliger, J A, Eizirik, D L, Cardozo, A K

“…Induction of the C/EBP homologous protein (CHOP) is considered a key event for endoplasmic reticulum (ER) stress-mediated apoptosis. Type 1 diabetes (T1D) is…”
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Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes by Igoillo-Esteve, M, Marselli, L, Cunha, D. A, Ladrière, L, Ortis, F, Grieco, F. A, Dotta, F, Weir, G. C, Marchetti, P, Eizirik, D. L, Cnop, M

“…Aims/hypothesis Beta cell failure is a crucial component in the pathogenesis of type 2 diabetes. One of the proposed mechanisms of beta cell failure is local…”
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Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans by Cinti, F., Mezza, T., Severi, I., Suleiman, M., Cefalo, C.M.A., Sorice, G.P., Moffa, S., Impronta, F., Quero, G., Alfieri, S., Mari, A., Pontecorvi, A., Marselli, L., Cinti, S., Marchetti, P., Giaccari, A.

“…Type 2 diabetes (T2D) is characterized by a progressive loss of beta-cell function, and the “disappearance” of beta-cells in T2D may also be caused by the…”
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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets by MARCHETTI, P, LUPI, R, BOGGI, U, FILIPPONI, F, TINTI, L, SALVINI, L, WOLLHEIM, C. B, PURRELLO, F, DOTTA, F, BUGLIANI, M, KIRKPATRICK, C. L, SEBASTIANI, G, GRIECO, F. A, DEL GUERRA, S, D'ALEO, V, PIRO, S, MARSELLI, L

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Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes by Weir, G.C, Marselli, L, Marchetti, P, Katsuta, H, Jung, M.H, Bonner-Weir, S

“…Type 2 diabetes (T2D) is characterized by reduction of β-cell mass and dysfunctional insulin secretion. Understanding β-cell phenotype changes as T2D…”
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β-Cell inflammation in human type 2 diabetes and the role of autophagy by Marselli, L., Bugliani, M., Suleiman, M., Olimpico, F., Masini, M., Petrini, M., Boggi, U., Filipponi, F., Syed, F., Marchetti, P.

“…β‐Cell failure is crucial for the onset and progression of human type 2 diabetes, and a few studies have suggested that inflammation may play a role. Immune…”
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Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio by Masini, M, Anello, M, Bugliani, M, Marselli, L, Filipponi, F, Boggi, U, Purrello, F, Occhipinti, M, Martino, L, Marchetti, P, De Tata, V

“…Abstract Aim We have explored whether the insulin secretory defects induced by glucotoxicity in human pancreatic islets could be prevented by metformin and…”
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Salvage of an Octogenarian Liver Graft Using Normothermic Perfusion: A Case Report by Pezzati, D, Ghinolfi, D, Balzano, E, De Simone, P, Coletti, L, Roffi, N, Rreka, E, Meacci, L, Campani, D, Mazzoni, A, Paolicchi, A, Caponi, L, Marchetti, P, Marselli, L, Filipponi, F

“…Abstract Liver transplantation with very old donors is safe, but is associated with an increased incidence of ischemic-type biliary lesions and delayed graft…”
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Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion by da Silva Xavier, G., Farhan, H., Kim, H., Caxaria, S., Johnson, P., Hughes, S., Bugliani, M., Marselli, L., Marchetti, P., Birzele, F., Sun, G., Scharfmann, R., Rutter, J., Siniakowicz, K., Weir, G., Parker, H., Reimann, F., Gribble, F. M., Rutter, G. A.

“…Aims/hypothesis We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. Methods…”
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Frequency and characteristics of diabetes in 300 pre-liver transplant patients by Marselli, L, De Simone, P, Morganti, R, Coletti, L, Carrai, P, Catalano, G, Tincani, G, Ghinolfi, D, Occhipinti, M, Filipponi, F, Marchetti, P

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Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation by Patané, G., Caporarello, N., Marchetti, P., Parrino, C., Sudano, D., Marselli, L., Vigneri, R., Frittitta, L.

“…The expression of adiponectin receptors has been demonstrated in human and rat pancreatic beta cells, where globular (g) adiponectin rescues rat beta cells…”
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Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes by Igoillo-Esteve, M., Marselli, L., Cunha, D. A., Ladrière, L., Ortis, F., Grieco, F. A., Dotta, F., Weir, G. C., Marchetti, P., Eizirik, D. L., Cnop, M.

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O60 Rôle des gènes associés au diabète de type 2, Arap1 et StarD10 dans le contrôle de la sécrétion d’insuline by Carrat, G, Pullen, T, Marselli, L, Marchetti, P, Rutter, G

“…Introduction Deux polymorphismes identifiés par des études GWAS affectent le niveau de proinsuline à jeun (rs11603334) et la sécrétion d’insuline induite par…”
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The common Arg972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets by Federici, Massimo, L. Hribal, Marta, Ranalli, Marco, Marselli, Lorella, Porzio, Ottavia, Lauro, Davide, Borboni, Patrizia, Lauro, Renato, Marchetti, Piero, Melino, Gerry, Sesti, Giorgio

“…ABSTRACT Molecular scanning of human IRS‐1 gene revealed a common polymorphism causing Gly →Arg972 change. Diabetic and pre‐diabetic carriers of Arg972 IRS‐1…”
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CO-68: L'étude génomique et fonctionnelle des gènes du diabète de type 2 confirme leur rôle dans les cellules beta-pancréatiques by Ndiaye, F, Ortalli, A, Verbanck, M, Huyvaert, M, Salazar-Cardozo, C, Yengo, L, Marselli, L, Marchetti, P, Froguel, P, Bonnefond, A

“…Introduction Grâce aux études d'association pangénomique [GWAS], plusieurs variants génétiques fréquents [SNPs] ont été identifiés associés au diabète de type…”
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NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro by PIERUCCI, D, CICCONI, S, OBERHOLZER, J, FEDERICI, M, COZZOLINO, F, LAURO, R, BORBONI, P, MARLIER, L. N. J. L, BONINI, P, FERRELLI, F, PASTORE, D, MATTEUCCI, C, MARSELLI, L, MARCHETTI, P, RIS, F, HALBAN, P

“…Using primary cultures of human pancreatic islets, purified human pancreatic beta cells and the mouse beta TC6-F7 cell line, we analysed the expression of…”
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