Search Results - "Marsden, Matthew D."

Benefits and limitations of humanized mice in HIV persistence studies by Marsden, Matthew D

“…Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent…”
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Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol by Liu, Su-Yang, Aliyari, Roghiyh, Chikere, Kelechi, Li, Guangming, Marsden, Matthew D., Smith, Jennifer K., Pernet, Olivier, Guo, Haitao, Nusbaum, Rebecca, Zack, Jerome A., Freiberg, Alexander N., Su, Lishan, Lee, Benhur, Cheng, Genhong

“…Interferons (IFN) are essential antiviral cytokines that establish the cellular antiviral state through upregulation of hundreds of interferon-stimulated genes…”
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Latency reversal plus natural killer cells diminish HIV reservoir in vivo by Kim, Jocelyn T., Zhang, Tian-Hao, Carmona, Camille, Lee, Bryanna, Seet, Christopher S., Kostelny, Matthew, Shah, Nisarg, Chen, Hongying, Farrell, Kylie, Soliman, Mohamed S. A., Dimapasoc, Melanie, Sinani, Michelle, Blanco, Kenia Yazmin Reyna, Bojorquez, David, Jiang, Hong, Shi, Yuan, Du, Yushen, Komarova, Natalia L., Wodarz, Dominik, Wender, Paul A., Marsden, Matthew D., Sun, Ren, Zack, Jerome A.

“…HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer…”
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HIV Persistence, Latency, and Cure Approaches: Where Are We Now? by Chou, Tessa C, Maggirwar, Nishad S, Marsden, Matthew D

“…The latent reservoir remains a major roadblock to curing human immunodeficiency virus (HIV) infection. Currently available antiretroviral therapy (ART) can…”
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In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication by Marsden, Matthew D, Loy, Brian A, Wu, Xiaomeng, Ramirez, Christina M, Schrier, Adam J, Murray, Danielle, Shimizu, Akira, Ryckbosch, Steven M, Near, Katherine E, Chun, Tae-Wook, Wender, Paul A, Zack, Jerome A

“…The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads to persistence and episodic resupply of the virus in patients…”
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Contribution of Sex Differences to HIV Immunology, Pathogenesis, and Cure Approaches by Moran, Jose A, Turner, Shireen R, Marsden, Matthew D

“…Approximately 38 million people were living with human immunodeficiency virus (HIV) in 2020 and 53% of those infected were female. A variety of virological and…”
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Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo by Beans, Elizabeth J., Fournogerakis, Dennis, Gauntlett, Carolyn, Heumann, Lars V., Kramer, Rainer, Marsden, Matthew D., Murray, Danielle, Chun, Tae-Wook, Zack, Jerome A., Wender, Paul A.

“…Highly active antiretroviral therapy (HAART) decreases plasma viremia below the limits of detection in the majority of HIV-infected individuals, thus serving…”
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Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window by Sloane, Jack L., Benner, Nancy L., Keenan, Katherine N., Zang, Xiaoyu, Soliman, Mohamed S. A., Wu, Xiaomeng, Dimapasoc, Melanie, Chun, Tae-Wook, Marsden, Matthew D., Zack, Jerome A., Wender, Paul A.

“…AIDS is a pandemic disease caused by HIV that affects 37 million people worldwide. Current antiretroviral therapy slows disease progression but does not…”
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Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy by Hardman, Clayton, Ho, Stephen, Shimizu, Akira, Luu-Nguyen, Quang, Sloane, Jack L., Soliman, Mohamed S. A., Marsden, Matthew D., Zack, Jerome A., Wender, Paul A.

“…Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell…”
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Activation of latent HIV using drug-loaded nanoparticles by Kovochich, Michael, Marsden, Matthew D, Zack, Jerome A

“…Antiretroviral therapy is currently only capable of controlling HIV replication rather than completely eradicating virus from patients. This is due in part to…”
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HIV Latency in the Humanized BLT Mouse by MARSDEN, Matthew D, KOVOCHICH, Michael, SUREE, Nuttee, SHIMIZU, Saki, MEHTA, Roshni, CORTADO, Ruth, BRISTOL, Gregory, SUNG AN, Dong, ZACK, Jerome A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents by Marsden, Matthew D., Wu, Xiaomeng, Navab, Sara M., Loy, Brian A., Schrier, Adam J., DeChristopher, Brian A., Shimizu, Akira J., Hardman, Clayton T., Ho, Stephen, Ramirez, Christina M., Wender, Paul A., Zack, Jerome A.

“…HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs)…”
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Double Trouble: HIV Latency and CTL Escape by Marsden, Matthew D., Zack, Jerome A.

“…HIV can enter a state of latency that allows it to persist for decades in antiretroviral drug-treated patients. In a recent Nature paper, Deng et al. (2015)…”
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Neutralizing the HIV Reservoir by Marsden, Matthew D., Zack, Jerome A.

“…Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency…”
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Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo by Pache, Lars, Marsden, Matthew D., Teriete, Peter, Portillo, Alex J., Heimann, Dominik, Kim, Jocelyn T., Soliman, Mohamed S.A., Dimapasoc, Melanie, Carmona, Camille, Celeridad, Maria, Spivak, Adam M., Planelles, Vicente, Cosford, Nicholas D.P., Zack, Jerome A., Chanda, Sumit K.

“…“Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and…”
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Disruption of Type I Interferon Induction by HIV Infection of T Cells by Sanchez, David Jesse, Miranda, Jr, Daniel, Marsden, Matthew D, Dizon, Thomas Michael A, Bontemps, Johnny R, Davila, Sergio J, Del Mundo, Lara E, Ha, Thai, Senaati, Ashkon, Zack, Jerome A, Cheng, Genhong

“…Our main objective of this study was to determine how Human Immunodeficiency Virus (HIV) avoids induction of the antiviral Type I Interferon (IFN) system. To…”
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Single Mutations in HIV Integrase Confer High-Level Resistance to Raltegravir in Primary Human Macrophages by MARSDEN, Matthew D, AVANCENA, Patricia, KITCHEN, Christina M. R, HUBBARD, Trish, ZACK, Jerome A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice by Shimizu, Saki, Ringpis, Gene-Errol, Marsden, Matthew D, Cortado, Ruth V, Wilhalme, Holly M, Elashoff, David, Zack, Jerome A, Chen, Irvin S Y, An, Dong Sung

“…Transplantation of hematopoietic stem/progenitor cells (HSPC) modified with a lentiviral vector bearing a potent nontoxic short hairpin RNA (sh1005) directed…”
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Human Immunodeficiency Virus Bearing a Disrupted Central DNA Flap Is Pathogenic In Vivo by MARSDEN, Matthew D, ZACK, Jerome A

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HIV establishes an early foothold by Moran, Jose A., Marsden, Matthew D.

“…The weeks following HIV acquisition are a critical time when the virus causes significant immunological damage and establishes long-term latent reservoirs. A…”
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