Search Results - "Marsden, Carolyn G."

Argonaute2 Is the Catalytic Engine of Mammalian RNAi by Liu, Jidong, Carmell, Michelle A., Rivas, Fabiola V., Marsden, Carolyn C., Thomson, J. Michael, Song, Ji-Joon, Hammond, Scott M., Joshua-Tor, Leemor, Hannon, Gregory J.

“…Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced silencing complex. RISC contains two signature components, small…”
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The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype by Marsden, Carolyn G, Jensen, Ryan B, Zagelbaum, Jennifer, Rothenberg, Eli, Morrical, Scott W, Wallace, Susan S, Sweasy, Joann B

“…The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we…”
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Disseminated breast cancer cells acquire a highly malignant and aggressive metastatic phenotype during metastatic latency in the bone by Marsden, Carolyn G, Wright, Mary Jo, Carrier, Latonya, Moroz, Krzysztof, Rowan, Brian G

“…Disseminated tumor cells (DTCs) in the bone marrow may exist in a dormant state for extended periods of time, maintaining the ability to proliferate upon…”
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"A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies" by Marsden, Carolyn G, Wright, Mary Jo, Carrier, Latonya, Moroz, Krzysztof, Pochampally, Radhika, Rowan, Brian G

“…The study of breast cancer metastasis depends on the use of established breast cancer cell lines that do not accurately represent the heterogeneity and…”
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Base Excision Repair Variants in Cancer by Marsden, Carolyn G, Dragon, Julie A, Wallace, Susan S, Sweasy, Joann B

“…Base excision repair (BER) is a key genome maintenance pathway that removes endogenously damaged DNA bases that arise in cells at very high levels on a daily…”
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Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability by Marsden, Carolyn G., Das, Lipsa, Nottoli, Timothy P., Kathe, Scott D., Doublié, Sylvie, Wallace, Susan S., Sweasy, Joann B.

“…Oxidative DNA damage as a result of normal cellular metabolism, inflammation, or exposure to exogenous DNA damaging agents if left unrepaired, can result in…”
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Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity by Marsden, Carolyn G., Jaruga, Pawel, Coskun, Erdem, Maher, Robyn L., Pederson, David S., Dizdaroglu, Miral, Sweasy, Joann B.

“…Oxidatively-induced DNA damage, widely accepted as a key player in the onset of cancer, is predominantly repaired by base excision repair (BER). BER is…”
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The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation by Galick, Heather A, Marsden, Carolyn G, Kathe, Scott, Dragon, Julie A, Volk, Lindsay, Nemec, Antonia A, Wallace, Susan S, Prakash, Aishwarya, Doublié, Sylvie, Sweasy, Joann B

“…Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of…”
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Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts by Anbalagan, Muralidharan, Ali, Alaa, Jones, Ryan K, Marsden, Carolyn G, Sheng, Mei, Carrier, Latonya, Bu, Yahao, Hangauer, David, Rowan, Brian G

“…Src kinase is elevated in breast tumors that are ER/PR negative and do not overexpress HER2, but clinical trials with Src inhibitors have shown little…”
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Breast tumor-initiating cells isolated from patient core biopsies for study of hormone action by Marsden, Carolyn G, Wright, Mary Jo, Pochampally, Radhika, Rowan, Brian G

“…In recent years, evidence has emerged supporting the hypothesis that cancer is a stem cell disease. The cancer stem cell field was led by the discovery of…”
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