Search Results - "Marschner, A."

De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime by Ballarotto, Marco, Willems, Sabine, Stiller, Tanja, Nawa, Felix, Marschner, Julian A., Grisoni, Francesca, Merk, Daniel

“…Generative neural networks trained on SMILES can design innovative bioactive molecules de novo. These so-called chemical language models (CLMs) have typically…”
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The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury by Anders, Hans-Joachim, Suarez-Alvarez, Beatriz, Grigorescu, Melissa, Foresto-Neto, Orestes, Steiger, Stefanie, Desai, Jyaysi, Marschner, Julian A, Honarpisheh, Mohsen, Shi, Chongxu, Jordan, Jutta, Müller, Lisa, Burzlaff, Nicolai, Bäuerle, Tobias, Mulay, Shrikant R

“…Primary/secondary hyperoxalurias involve nephrocalcinosis-related chronic kidney disease (CKD) leading to end-stage kidney disease. Mechanistically, intrarenal…”
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Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury by Lazzeri, Elena, Angelotti, Maria Lucia, Peired, Anna, Conte, Carolina, Marschner, Julian A., Maggi, Laura, Mazzinghi, Benedetta, Lombardi, Duccio, Melica, Maria Elena, Nardi, Sara, Ronconi, Elisa, Sisti, Alessandro, Antonelli, Giulia, Becherucci, Francesca, De Chiara, Letizia, Guevara, Ricardo Romero, Burger, Alexa, Schaefer, Beat, Annunziato, Francesco, Anders, Hans-Joachim, Lasagni, Laura, Romagnani, Paola

“…Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell…”
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Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration by Iwakura, Takamasa, Zhao, Zhibo, Marschner, Julian A, Devarapu, Satish Kumar, Yasuda, Hideo, Anders, Hans Joachim

“…Abstract Background Cisplatin is an effective chemotherapeutic agent. However, acute kidney injury (AKI) and subsequent kidney function decline limits its use…”
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Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI by Mulay, Shrikant Ramesh, Honarpisheh, Mohsen M, Foresto-Neto, Orestes, Shi, Chongxu, Desai, Jyaysi, Zhao, Zhi Bo, Marschner, Julian A, Popper, Bastian, Buhl, Ewa Miriam, Boor, Peter, Linkermann, Andreas, Liapis, Helen, Bilyy, Rostyslav, Herrmann, Martin, Romagnani, Paola, Belevich, Ilya, Jokitalo, Eija, Becker, Jan U, Anders, Hans-Joachim

“…Serum oxalate levels suddenly increase with certain dietary exposures or ethylene glycol poisoning and are a well known cause of AKI. Established contributors…”
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Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation by Andersen, Kirstin, Kesper, Marie Sophie, Marschner, Julian A, Konrad, Lukas, Ryu, Mi, Kumar Vr, Santhosh, Kulkarni, Onkar P, Mulay, Shrikant R, Romoli, Simone, Demleitner, Jana, Schiller, Patrick, Dietrich, Alexander, Müller, Susanna, Gross, Oliver, Ruscheweyh, Hans-Joachim, Huson, Daniel H, Stecher, Bärbel, Anders, Hans-Joachim

“…CKD associates with systemic inflammation, but the underlying cause is unknown. Here, we investigated the involvement of intestinal microbiota. We report that…”
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Chemogenomics for NR1 nuclear hormone receptors by Isigkeit, Laura, Schallmayer, Espen, Busch, Romy, Brunello, Lorene, Menge, Amelie, Elson, Lewis, Müller, Susanne, Knapp, Stefan, Stolz, Alexandra, Marschner, Julian A., Merk, Daniel

“…Nuclear receptors (NRs) regulate transcription in response to ligand binding and NR modulation allows pharmacological control of gene expression. Although some…”
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Automated design of multi-target ligands by generative deep learning by Isigkeit, Laura, Hörmann, Tim, Schallmayer, Espen, Scholz, Katharina, Lillich, Felix F., Ehrler, Johanna H. M., Hufnagel, Benedikt, Büchner, Jasmin, Marschner, Julian A., Pabel, Jörg, Proschak, Ewgenij, Merk, Daniel

“…Generative deep learning models enable data-driven de novo design of molecules with tailored features. Chemical language models (CLM) trained on string…”
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Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease by Mulay, Shrikant R, Eberhard, Jonathan N, Desai, Jyaysi, Marschner, Julian A, Kumar, Santhosh V R, Weidenbusch, Marc, Grigorescu, Melissa, Lech, Maciej, Eltrich, Nuru, Müller, Lisa, Hans, Wolfgang, Hrabě de Angelis, Martin, Vielhauer, Volker, Hoppe, Bernd, Asplin, John, Burzlaff, Nicolai, Herrmann, Martin, Evan, Andrew, Anders, Hans-Joachim

“…Intrarenal crystals trigger inflammation and renal cell necroptosis, processes that involve TNF receptor (TNFR) signaling. Here, we tested the hypothesis that…”
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Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis by Honarpisheh, Mohsen, Desai, Jyaysi, Marschner, Julian A, Weidenbusch, Marc, Lech, Maciej, Vielhauer, Volker, Anders, Hans-Joachim, Mulay, Shrikant R

“…The species-specific, as well as organ-specific expression of regulated necrosis (RN)-related molecules, is not known. We determined the expression levels of…”
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Optimizing Mouse Surgery with Online Rectal Temperature Monitoring and Preoperative Heat Supply. Effects on Post-Ischemic Acute Kidney Injury by Marschner, Julian A, Schäfer, Hannah, Holderied, Alexander, Anders, Hans-Joachim

“…Body temperature affects outcomes of tissue injury. We hypothesized that online body core temperature recording and selective interventions help to standardize…”
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No NLRP3 inflammasome activity in kidney epithelial cells, not even when the NLRP3-A350V Muckle-Wells variant is expressed in podocytes of diabetic mice by Kunte, Sophie Carina, Marschner, Julian A., Klaus, Martin, Honda, Tâmisa, Li, Chenyu, Motrapu, Manga, Walz, Christoph, Angelotti, Maria Lucia, Antonelli, Giulia, Melica, Maria Elena, De Chiara, Letizia, Semeraro, Roberto, Nelson, Peter J., Anders, Hans-Joachim

“…BackgroundThe NLRP3 inflammasome integrates several danger signals into the activation of innate immunity and inflammation by secreting IL-1β and IL-18. Most…”
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Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury by Weidenbusch, Marc, Rodler, Severin, Song, Shangqing, Romoli, Simone, Marschner, Julian A, Kraft, Franziska, Holderied, Alexander, Kumar, Santosh, Mulay, Shrikant R, Honarpisheh, Mohsen, Kumar Devarapu, Satish, Lech, Maciej, Anders, Hans-Joachim

“…Notch and interleukin-22 (IL-22) signaling are known to regulate tissue homeostasis and respond to injury in humans and mice, and the induction of endogenous…”
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Nurr1 Modulation Mediates Neuroprotective Effects of Statins by Willems, Sabine, Marschner, Julian A., Kilu, Whitney, Faudone, Giuseppe, Busch, Romy, Duensing‐Kropp, Silke, Heering, Jan, Merk, Daniel

“…The ligand‐sensing transcription factor Nurr1 emerges as a promising therapeutic target for neurodegenerative pathologies but Nurr1 ligands for functional…”
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The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease by Marschner, Julian A, Mulay, Shrikant R, Steiger, Stefanie, Anguiano, Lidia, Zhao, Zhibo, Boor, Peter, Rahimi, Khosrow, Inforzato, Antonio, Garlanda, Cecilia, Mantovani, Alberto, Anders, Hans-Joachim

“…The long pentraxin 3 (PTX3) exerts a variety of regulatory functions in acute and chronic tissue inflammation. In particular, PTX3 acts as an opsonin for a…”
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Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial by Waclawovsky, Gustavo, Boll, Liliana F. C., Eibel, Bruna, Alegretti, Ana Paula, Spagnol, Fabiane, De Paoli, Juliana, Wajner, Simone, Marschner, Rafael A., Schaun, Maximiliano I., Lehnen, Alexandre Machado

“…To examine the acute effects of aerobic exercise (AE), resistance exercise (RE) or combined exercise (CE) on flow-mediated dilation (FMD), progenitor cells…”
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Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery by Zhao, Zhi Bo, Marschner, Julian A, Iwakura, Takamasa, Li, Chenyu, Motrapu, Manga, Kuang, Meisi, Popper, Bastian, Linkermann, Andreas, Klocke, Jan, Enghard, Philipp, Muto, Yoshiharu, Humphreys, Benjamin D, Harris, Helena Erlandsson, Romagnani, Paola, Anders, Hans-Joachim

“…Cells undergoing necrosis release extracellular high mobility group box (HMGB)-1, which triggers sterile inflammation upon AKI in mice. Neither deletion of…”
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Glomerular parietal epithelial cell activation induces collagen secretion and thickening of Bowman's capsule in diabetes by Holderied, Alexander, Romoli, Simone, Eberhard, Jonathan, Konrad, Lukas A, Devarapu, Satish K, Marschner, Julian A, Müller, Susanna, Anders, Hans-Joachim

“…The metabolic and hemodynamic alterations in diabetes activate podocytes to increase extracellular matrix (ECM) production, leading to thickening of the…”
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Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing by Sai, Minh, Hank, Emily C., Tai, Hin-Man, Kasch, Till, Lewandowski, Max, Vincendeau, Michelle, Marschner, Julian A., Merk, Daniel

“…The neuroprotective transcription factor nuclear receptor-related 1 (Nurr1) has shown great promise as a therapeutic target in Parkinson’s and Alzheimer’s…”
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Evaluation of the Diagnostic Value of Contrast-Enhanced Voiding Urosonography with Regard to the Further Therapy Regime and Patient Outcome-A Single-Center Experience in an Interdisciplinary Uroradiological Setting by Marschner, Constantin A, Schwarze, Vincent, Stredele, Regina, Froelich, Matthias F, Rübenthaler, Johannes, Geyer, Thomas, Clevert, Dirk-André

“…: Vesicoureteral reflux (VUR) describes a common pediatric anomaly in pediatric urology with a prevalence of 1-2%. In diagnostics, in addition to the gold…”
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