Search Results - "Marschall, Maximilian K."
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Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation
Published in Molecular and cellular endocrinology (05-01-2017)“…To investigate the role of DRO1 in obesity and adipogenesis in vivo, we generated a constitutive Dro1 knockout mouse model and analyzed the effect of DRO1 loss…”
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Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice
Published in Carcinogenesis (New York) (21-09-2018)“…This study demonstrates DRO1 to be a strong tumor suppressor in chemically induced colon carcinogenesis. Loss of DRO1 increases multiplicity of preneoplastic…”
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Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis
Published in Oncotarget (11-04-2022)“…Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk…”
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DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice
Published in Molecular cancer research (01-11-2014)“…Colorectal cancer develops from adenomatous precursor lesions by a multistep process that involves several independent mutational events in oncogenes and tumor…”
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