Search Results - "Marschall, Andrea L."

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells by Zehner, Matthias, Marschall, Andrea L., Bos, Erik, Schloetel, Jan-Gero, Kreer, Christoph, Fehrenschild, Dagmar, Limmer, Andreas, Ossendorp, Ferry, Lang, Thorsten, Koster, Abraham J., Dübel, Stefan, Burgdorf, Sven

“…The molecular mechanisms regulating antigen translocation into the cytosol for cross-presentation are under controversial debate, mainly because direct data is…”
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Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides by Allen, Jason, Najjar, Kristina, Erazo-Oliveras, Alfredo, Kondow-McConaghy, Helena M, Brock, Dakota J, Graham, Kristin, Hager, Elizabeth C, Marschall, Andrea L. J, Dübel, Stefan, Juliano, Rudolph L, Pellois, Jean-Philippe

“…Ineffective cellular delivery is a common problem in numerous biological applications. Developing delivery reagents that work robustly in a variety of…”
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Specific in vivo knockdown of protein function by intrabodies by Marschall, Andrea LJ, Dübel, Stefan, Böldicke, Thomas

“…Intracellular antibodies (intrabodies) are recombinant antibody fragments that bind to target proteins expressed inside of the same living cell producing the…”
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Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis - impact of radiochemistry on pharmacokinetics by Bala, Gezim, Crauwels, Maxine, Blykers, Anneleen, Remory, Isabel, Marschall, Andrea L J, Dübel, Stefan, Dumas, Laurent, Broisat, Alexis, Martin, Charlotte, Ballet, Steven, Cosyns, Bernard, Caveliers, Vicky, Devoogdt, Nick, Xavier, Catarina, Hernot, Sophie

“…Radiolabeling of nanobodies with radiometals by chelation has the advantage of being simple, fast and easy to implement in clinical routine. In this study, we…”
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Delivery of antibodies to the cytosol: Debunking the myths by Marschall, Andrea LJ, Zhang, Congcong, Frenzel, André, Schirrmann, Thomas, Hust, Michael, Perez, Franck, Dübel, Stefan

“…The use of antibodies to target their antigens in living cells is a powerful analytical tool for cell biology research. Not only can molecules be localized and…”
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Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cells by Zhang, Congcong, Helmsing, Saskia, Zagrebelsky, Marta, Schirrmann, Thomas, Marschall, Andrea L J, Schüngel, Manuela, Korte, Martin, Hust, Michael, Dübel, Stefan

“…Although p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained…”
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Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy by Marschall, Andrea L. J.

“…Delivering macromolecules into the cytosol or nucleus is possible in vitro for DNA, RNA and proteins, but translation for clinical use has been limited…”
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Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context by Ruschig, Maximilian, Marschall, Andrea L. J.

“…Numerous toxins translocate to the cytosol in order to fulfil their function. This demonstrates the existence of routes for proteins from the extracellular…”
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Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology by Zhang, Congcong, Ötjengerdes, Rina M., Roewe, Julian, Mejias, Rebeca, Marschall, Andrea L. J.

“…To interfere with cell function, many scientists rely on methods that target DNA or RNA due to the ease with which they can be applied. Proteins are usually…”
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Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm? by Marschall, Andrea L.J., Dübel, Stefan

“…Challenges posed by complex diseases such as cancer, chronic viral infections, neurodegenerative disorders and many others have forced researchers to think…”
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Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells by Marschall, Andrea L J, Zhang, Congcong, Dübel, Stefan

“…Delivery of proteins to the cytosol of living cells is a promising research tool. Delivery of antibodies in particular bears exciting applications such as in…”
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Induction of broadly neutralizing antibodies in Germinal Centre simulations by Robert, Philippe A, Marschall, Andrea LJ, Meyer-Hermann, Michael

“…[Display omitted] •Developing vaccines against mutating pathogens is very challenging.•Two theories were suggested: sequential versus simultaneous…”
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Recent Advances with ER Targeted Intrabodies by Marschall, Andrea L J, Dübel, Stefan, Böldicke, Thomas

“…ER intrabodies are recombinant antibody fragments produced and retained in the endoplasmatic reticulum (ER) of a cell or an organism with the purpose to induce…”
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Targeting antibodies to the cytoplasm by Marschall, Andrea L.J., Frenzel, André, Schirrmann, Thomas, Schüngel, Manuela, Dubel, Stefan

“…A growing number of research consortia are now focused on generating antibodies and recombinant antibody fragments that target the human proteome. A…”
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Neue Impulse für den Protein-Knock-down mit intrabodies by Dübel, Stefan, Marschall, Andrea L. J.

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Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies by Marschall, Andrea L J, Single, Frank N, Schlarmann, Katrin, Bosio, Andreas, Strebe, Nina, van den Heuvel, Joop, Frenzel, André, Dübel, Stefan

“…Functional knockdowns mediated by endoplasmatic reticulum-retained antibodies (ER intrabodies) are a promising tool for research because they allow functional…”
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Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies by Marschall, Andrea LJ, Single, Frank N, Schlarmann, Katrin, Bosio, Andreas, Strebe, Nina, van den Heuvel, Joop, Frenzel, André, Dübel, Stefan

“…Functional knockdowns mediated by endoplasmatic reticulum-retained antibodies (ER intrabodies) are a promising tool for research because they allow functional…”
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