Search Results - "Marschalek, Rolf"

Mechanisms of leukemogenesis by MLL fusion proteins by Marschalek, Rolf

“…Summary Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid onset of disease shortly after birth. The vast majority of these…”
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Another piece of the puzzle added to understand t(4;11) leukemia better by Marschalek, Rolf

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The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(4;11) by Wilhelm, Alexander, Marschalek, Rolf

“…Leukemia patients bearing the t(4;11)(q21;q23) translocations can be divided into two subgroups: those expressing both reciprocal fusion genes, and those that…”
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Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways by Marschalek, Rolf

“…Chromosomal translocations of the human mixed-lineage leukemia (MLL) gene have been analyzed for more than 20 yr at the molecular level. So far, we have…”
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SARS-CoV-2: The Virus, Its Biology and COVID-19 Disease-Counteracting Possibilities by Marschalek, Rolf

“…Since the end of 2019, the SARS-CoV-2 virus started to spread in different countries, leading to a world-wide pandemia, with today's infection numbers of more…”
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Mixed lineage leukemia: roles in human malignancies and potential therapy by Marschalek, Rolf

“…The increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for…”
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Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines by Kowarz, Eric, Löscher, Denise, Marschalek, Rolf

“…Stable gene expression in mammalian cells is a prerequisite for many in vitro and in vivo experiments. However, either the integration of plasmids into…”
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The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(6;11) by Kundu, Arpita, Kowarz, Eric, Marschalek, Rolf

“…Leukemia patients bearing t(6;11)(q27;q23) translocations can be divided in two subgroups: those with breakpoints in the major breakpoint cluster region of MLL…”
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Vaccine-induced COVID-19 mimicry syndrome by Kowarz, Eric, Krutzke, Lea, Külp, Marius, Streb, Patrick, Larghero, Patrizia, Reis, Jennifer, Bracharz, Silvia, Engler, Tatjana, Kochanek, Stefan, Marschalek, Rolf

“…To fight the COVID-19 pandemic caused by the RNA virus SARS-CoV-2, a global vaccination campaign is in progress to achieve the immunization of billions of…”
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Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies by Wilhelm, Alexander, Widera, Marek, Grikscheit, Katharina, Toptan, Tuna, Schenk, Barbara, Pallas, Christiane, Metzler, Melinda, Kohmer, Niko, Hoehl, Sebastian, Marschalek, Rolf, Herrmann, Eva, Helfritz, Fabian A., Wolf, Timo, Goetsch, Udo, Ciesek, Sandra

“…In recent months, Omicron variants of SARS-CoV-2 have become dominant in many regions of the world, and case numbers with Omicron subvariants BA.1 and BA.2…”
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Image-Based Annotation of Chemogenomic Libraries for Phenotypic Screening by Tjaden, Amelie, Chaikuad, Apirat, Kowarz, Eric, Marschalek, Rolf, Knapp, Stefan, Schröder, Martin, Müller, Susanne

“…Phenotypical screening is a widely used approach in drug discovery for the identification of small molecules with cellular activities. However, functional…”
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The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4 by Bursen, Adelheid, Schwabe, Karen, Rüster, Brigitte, Henschler, Reinhard, Ruthardt, Martin, Dingermann, Theo, Marschalek, Rolf

“…The chromosomal translocation t(4;11)(q21;q23) is the most frequent genetic aberration of the human MLL gene, resulting in high-risk acute lymphoblastic…”
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Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth by Hartmann, Daniela, Lucks, Jessica, Fuchs, Sina, Schiffmann, Susanne, Schreiber, Yannick, Ferreirós, Nerea, Merkens, Jennifer, Marschalek, Rolf, Geisslinger, Gerd, Grösch, Sabine

“…Ceramides are known to be key players in intracellular signaling and are involved in apoptosis, cell senescence, proliferation, cell growth and…”
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Targeted Next-Generation Sequencing for Detecting MLL Gene Fusions in Leukemia by Afrin, Sadia, Zhang, Christine R C, Meyer, Claus, Stinson, Caedyn L, Pham, Thy, Bruxner, Timothy J C, Venn, Nicola C, Trahair, Toby N, Sutton, Rosemary, Marschalek, Rolf, Fink, J Lynn, Moore, Andrew S

“…Mixed lineage leukemia ( ) gene rearrangements characterize approximately 70% of infant and 10% of adult and therapy-related leukemia. Conventional clinical…”
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Erratum to : Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard risk acute myeloid leukemia by Maurer-Granofszky, Margarita, Köhrer, Stefan, Fischer, Susanna, Schumich, Angela, Nebral, Karin, Larghero, Patrizia, Meyer, Claus, Mecklenbräuker, Astrid, Mühlegger, Nora, Marschalek, Rolf, Haas, Oskar A, Panzer-Grümayer, Renate, Dworzak, Michael N

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Generation of a Sleeping Beauty Transposon-Based Cellular System for Rapid and Sensitive Screening for Compounds and Cellular Factors Limiting SARS-CoV-2 Replication by Widera, Marek, Wilhelm, Alexander, Toptan, Tuna, Raffel, Johanna M., Kowarz, Eric, Roesmann, Fabian, Grözinger, Finn, Siemund, Anna Lena, Luciano, Vanessa, Külp, Marius, Reis, Jennifer, Bracharz, Silvia, Pallas, Christiane, Ciesek, Sandra, Marschalek, Rolf

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the acute respiratory disease COVID-19, which has become a global…”
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MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway by Siemund, Anna Lena, Hanewald, Thomas, Kowarz, Eric, Marschalek, Rolf

“…Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce…”
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Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard-risk acute myeloid leukemia by Maurer-Granofszky, Margarita, Kohrer, Stefan, Fischer, Susanna, Schumich, Angela, Nebral, Karin, Larghero, Patrizia, Meyer, Claus, Mecklenbrauker, Astrid, Muhlegger, Nora, Marschalek, Rolf, Haas, Oskar A, Panzer-Grumayer, Renate, Dworzak, Michael N

“…Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease making standardized measurable residual disease (MRD) assessment challenging…”
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How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining by Streb, Patrick, Kowarz, Eric, Benz, Tamara, Reis, Jennifer, Marschalek, Rolf

“…Chromosomal translocations (CTs) are a genetic hallmark of cancer. They could be identified as recurrent genetic aberrations in hemato-malignancies and solid…”
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Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial-Mesenchymal Transition by Ibrahim, Ahmed Atef, Schmithals, Christian, Kowarz, Erik, Köberle, Verena, Kakoschky, Bianca, Pleli, Thomas, Kollmar, Otto, Nitsch, Scarlett, Waidmann, Oliver, Finkelmeier, Fabian, Zeuzem, Stefan, Korf, Horst-Werner, Schmid, Tobias, Weigert, Andreas, Kronenberger, Bernd, Marschalek, Rolf, Piiper, Albrecht

“…A role of Dicer, which converts precursor miRNAs to mature miRNAs, in the tumor-promoting effect of hypoxia is currently emerging in some tumor entities. Its…”
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