Search Results - "Marsac, Patrick"

On the particle formation in spray drying process for bio-pharmaceutical applications: Interrogating a new model via computational fluid dynamics by Poozesh, Sadegh, Lu, Kun, Marsac, Patrick J.

“…•A brief overview on particle formation models for spray drying process is presented.•A modified CDC model incorporated into CFD is applied on characterized…”
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Estimation of Drug-Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters by Marsac, Patrick J, Li, Tonglei, Taylor, Lynne S

“…Purpose The amorphous form of a drug may provide enhanced solubility, dissolution rate, and bioavailability but will also potentially crystallize over time…”
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A comparison of the physical stability of amorphous felodipine and nifedipine systems by MARSAC, Patrick J, KONNO, Hajime, TAYLOR, Lynne S

“…The objective of this study was to investigate thermodynamic and kinetic factors contributing to differences in the isothermal nucleation rates of two…”
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Multicomponent Droplet Drying Modeling Based on Conservation and Population Balance Equations by Poozesh, Sadegh, Algasem, Faisal, Azad, Mohammad A., Marsac, Patrick J.

“…The aim of this work is to present a modeling tool to describe drying kinetics and delineate evolving physical and chemical behavior of multicomponent droplets…”
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Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility by MARSAC, Patrick J, SHAMBLIN, Sheri L, TAYLOR, Lynne S

“…Crystallization of drugs formulated in the amorphous form may lead to reduced apparent solubility, decreased rate of dissolution and bioavailability and…”
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Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids by Yildiz, Hasan M., McKelvey, Craig A., Marsac, Patrick J., Carrier, Rebecca L.

“…Intestinal mucus provides a significant barrier to transport of orally delivered drug carriers, as well as other particulates (e.g. food, microbes). The…”
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Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions by Nie, Haichen, Su, Yongchao, Zhang, Mingtao, Song, Yang, Leone, Anthony, Taylor, Lynne S, Marsac, Patrick J, Li, Tonglei, Byrn, Stephen R

“…It has been technically challenging to specify the detailed molecular interactions and binding motif between drugs and polymeric inhibitors in the solid state…”
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Assessment of predictive models for characterizing the atomization process in a spray dryer’s bi-fluid nozzle by Poozesh, Sadegh, Setiawan, Nico, Akafuah, Nelson K., Saito, Kozo, Marsac, Patrick J.

“…Droplet size distribution which is a pivotal factor affecting both size and morphology distribution of the final dried particle is investigated and…”
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Insights into Water-Induced Phase Separation in Itraconazole–Hydroxypropylmethyl Cellulose Spin Coated and Spray Dried Dispersions by Mugheirbi, Naila A, Marsac, Patrick J, Taylor, Lynne S

“…For amorphous solid dispersions, understanding the phase behavior of a given drug–polymer blend and factors that influence miscibility is crucial to designing…”
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Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone) by Marsac, Patrick J, Rumondor, Alfred C F, Nivens, David E, Kestur, Umesh S, Stanciu, Lia, Taylor, Lynne S

“…The physical stability of amorphous molecular level solid dispersions will be influenced by the miscibility of the components. The goal of this work was to…”
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Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation by Nie, Haichen, Xu, Wei, Taylor, Lynne S., Marsac, Patrick J., Byrn, Stephen R.

“…[Display omitted] Salt disproportionation (a conversion from the ionized to the neutral state) in solid formulations is a potential concern during…”
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Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations by Poozesh, Sadegh, Grib, Stephen W., Renfro, Michael W., Marsac, Patrick J.

“…The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates…”
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Analytical approaches to investigate salt disproportionation in tablet matrices by Raman spectroscopy and Raman mapping by Nie, Haichen, Liu, Zhen, Marks, Brian C, Taylor, Lynne S, Byrn, Stephen R, Marsac, Patrick J

“…It has always been challenging to use spectroscopic methods to analyze salt disproportionation in a multi-component tablet matrix due to the spectral…”
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Phase Behavior of Poly(vinylpyrrolidone) Containing Amorphous Solid Dispersions in the Presence of Moisture by Rumondor, Alfred C. F, Marsac, Patrick J, Stanford, Lindsay A, Taylor, Lynne S

“…The objective of this study was to investigate the phase behavior of amorphous solid dispersions composed of a hydrophobic drug and a hydrophilic polymer…”
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Approaches to Understanding the Solution-State Organization of Spray-Dried Dispersion Feed Solutions and Its Translation to the Solid State by Defrese, Matthew K, Farmer, Matthew A, Long, Yuhan, Timmerman, Lucas R, Bae, Younsoo, Marsac, Patrick J

“…It is well established that polymers adopt a range of conformations and solution-state organization in response to varying solution environments, although very…”
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Toward Developing Discriminating Dissolution Methods for Formulations Containing Nanoparticulates in Solution: The Impact of Particle Drift and Drug Activity in Solution by Arce, Freddy A, Setiawan, Nico, Campbell, Heather R, Lu, Xingyu, Nethercott, Matthew J, Bummer, Paul, Su, Yongchao, Marsac, Patrick J

“…Enabling formulations are an attractive approach to increase the dissolution rate, solubility, and oral bioavailability of poorly soluble compounds. With the…”
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Impact of polymer type on bioperformance and physical stability of hot melt extruded formulations of a poorly water soluble drug by Mitra, Amitava, Li, Li, Marsac, Patrick, Marks, Brian, Liu, Zhen, Brown, Chad

“…[Display omitted] Amorphous solid dispersion formulations have been widely used to enhance bioavailability of poorly soluble drugs. In these formulations,…”
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Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations by Nie, Haichen, Xu, Wei, Ren, Jie, Taylor, Lynne S, Marsac, Patrick J, John, Christopher T, Byrn, Stephen R

“…Excipient-induced salt disproportionation (conversion from salt form to free form) in the solid state during storage or manufacturing is a severe formulation…”
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Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions by Correa-Soto, Clara, Trasi, Niraj S., Schmitt, Paul D., Su, Yongchao, Liu, Zhen, Miller, Elise, Variankaval, Narayan, Marsac, Patrick J., Simpson, Garth J., Taylor, Lynne S.

“…•Second harmonic generation (SHG) microscopy was applied for sensitive detection of crystallinity in spray dried particles.•SHG detected crystallinity at an…”
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Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy by Lu, Xingyu, Li, Mingyue, Arce, Freddy A, Ling, Jing, Setiawan, Nico, Wang, Yaqiang, Shi, Xiaohuo, Campbell, Heather R, Nethercott, Matthew J, Xu, Wei, Munson, Eric J, Marsac, Patrick J, Su, Yongchao

“…The introduction of solubilizing additives has historically been an attractive approach to address the ever-growing proportion of poorly water-soluble drug…”
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