Search Results - "Marroquin, Lisa D."

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells by Will, Yvonne, Dykens, James A., Nadanaciva, Sashi, Hirakawa, Brad, Jamieson, Joseph, Marroquin, Lisa D., Hynes, James, Patyna, Shem, Jessen, Bart A.

“…Cardiovascular disease has recently been suggested to be a significant complication of cancer treatment with several kinase inhibitors. In some cases, the…”
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In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone by Dykens, James A., Jamieson, Joseph D., Marroquin, Lisa D., Nadanaciva, Sashi, Xu, Jinghai J., Dunn, Margaret C., Smith, Arthur R., Will, Yvonne

“…Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S…”
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Mechanistic investigation of imatinib-induced cardiac toxicity and the involvement of c-Abl kinase by Hu, Wenyue, Lu, Shuyan, McAlpine, Indrawan, Jamieson, Joseph D, Lee, Dong U, Marroquin, Lisa D, Heyen, Jonathan R, Jessen, Bart A

“…The Bcr-abl tyrosine kinase inhibitor imatinib mesylate is the frontline therapy for chronic myeloid leukemia. Imatinib has been reported to cause congestive…”
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Bacillus thuringiensis (Bt) Toxin Susceptibility and Isolation of Resistance Mutants in the Nematode Caenorhabditis elegans by Marroquin, Lisa D, Elyassnia, Dino, Griffitts, Joel S, Feitelson, Jerald S, Aroian, Raffi V

“…The protein toxins produced by Bacillus thuringiensis (Bt) are the most widely used natural insecticides in agriculture. Despite successful and extensive use…”
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Resistance to a Bacterial Toxin Is Mediated by Removal of a Conserved Glycosylation Pathway Required for Toxin-Host Interactions by Griffitts, Joel S., Huffman, Danielle L., Whitacre, Johanna L., Barrows, Brad D., Marroquin, Lisa D., Müller, Reto, Brown, Jillian R., Hennet, Thierry, Esko, Jeffrey D., Aroian, Raffi V.

“…Crystal (Cry) proteins made by the bacterium Bacillus thuringiensis are pore-forming toxins that specifically target insects and nematodes and are used around…”
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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants by Marroquin, Lisa D., Hynes, James, Dykens, James A., Jamieson, Joseph D., Will, Yvonne

“…Many highly proliferative cells generate almost all ATP via glycolysis despite abundant O2 and a normal complement of fully functional mitochondria, a…”
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An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury by Oda, Shingo, Uchida, Yuka, Aleo, Michael D., Koza-Taylor, Petra H., Matsui, Yusuke, Hizue, Masanori, Marroquin, Lisa D., Whritenour, Jessica, Uchida, Eri, Yokoi, Tsuyoshi

“…Preventing clinical drug-induced liver injury (DILI) remains a major challenge, because DILI develops via multifactorial mechanisms. Immune and inflammatory…”
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Investigation of Drug-Induced Mitochondrial Toxicity Using Fluorescence-Based Oxygen-Sensitive Probes by Hynes, James, Marroquin, Lisa D., Ogurtsov, Vladimir I., Christiansen, Katerina N., Stevens, Gregory J., Papkovsky, Dmitri B., Will, Yvonne

“…Mitochondrial dysfunction is a common mechanism of drug-induced toxicity. Early identification of new chemical entities (NCEs) that perturb mitochondrial…”
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Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites by Li, Rui, Bi, Yi-An, Vildhede, Anna, Scialis, Renato J, Mathialagan, Sumathy, Yang, Xin, Marroquin, Lisa D, Lin, Jian, Varma, Manthena V S

“…Glyburide is widely used for the treatment of type 2 diabetes. We studied the mechanisms involved in the disposition of glyburide and its pharmacologically…”
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Strategies to reduce late-stage drug attrition due to mitochondrial toxicity by Dykens, James A, Marroquin, Lisa D, Will, Yvonne

“…Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities and negative side-effect profiles. Early identification of…”
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Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis by Lapham, Kimberly, Novak, Jonathan, Marroquin, Lisa D, Swiss, Rachel, Qin, Shuzhen, Strock, Christopher J, Scialis, Renato, Aleo, Michael D, Schroeter, Thomas, Eng, Heather, Rodrigues, A. David, Kalgutkar, Amit S

“…Conjugated hyperbilirubinemia accompanied by cholestasis is a frequent side effect during chronic treatment with the antimicrobial agent fusidic acid. Previous…”
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Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901 by Torti, Vince R, Wojciechowicz, Donald, Hu, Wenyue, John-Baptiste, Annette, Evering, Winston, Troche, Gabriel, Marroquin, Lisa D, Smeal, Tod, Yamazaki, Shinji, Palmer, Cynthia L, Burns-Naas, Leigh Ann, Bagrodia, Shubha

“…Clinical trials of selective RAF inhibitors in patients with melanoma tumors harboring activated BRAFV600E have produced very promising results, and a RAF…”
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Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS-Based Detection Methods by Marroquin, Lisa D, Bonin, Paul D, Keefer, Julie, Schroeter, Thomas

“…The bile salt export pump (BSEP, ABCB11) belongs to the ATP-binding-cassette superfamily of transporters and is predominately found in the liver. BSEP is an…”
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