Search Results - "Marrone, April K."

New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye by Marrone, April K, Kucherenko, Mariya M, Rishko, Valentyna M, Shcherbata, Halyna R

“…The Dystrophin Glycoprotein Complex (DGC) is a large multi-component complex that is well known for its function in muscle tissue. When the main components of…”
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The Regulatory Perspectives on Endoscopic Devices for Obesity by Marrone, April K., PhD, MBA, Antonino, Mark J., MS, Silverstein, Joshua S., PhD, Betz, Martha W., PhD, Venkataraman-Rao, Priya, MD, Golding, Martin, MD, Cordray, Diane, VMD, Cooper, Jeffrey W., DVM

“…The recent increase in US Food and Drug Administration-approved weight-loss devices has diversified obesity treatment options. The regulatory pathways for…”
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Dystrophin Orchestrates the Epigenetic Profile of Muscle Cells Via miRNAs by Marrone, April K, Shcherbata, Halyna R

“…Mammalian musculature is a very robust and dynamic tissue that goes through many rounds of degeneration and regeneration in an individual's lifetime. There is…”
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US Food and Drug Administration and Off-Label Use of Metal Expandable Biliary Stents within the Peripheral Vasculature—Update by Marrone, April K., Gottschalk, Laura, Chen, Allen L.

“…In the past, some medical device manufacturers were obtaining marketing clearance for metallic stents indicated for biliary use; however, these devices were…”
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MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells by Marrone, April K, Tryndyak, Volodymyr, Beland, Frederick A, Pogribny, Igor P

“…Recent advances in toxicogenomics present an opportunity to develop new in vitro testing methodologies to identify human carcinogens. We have investigated…”
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MicroRNA-17~92 Is Required for Nephrogenesis and Renal Function by MARRONE, April K, STOLZ, Donna B, BASTACKY, Sheldon I, KOSTKA, Dennis, BODNAR, Andrew J, HO, Jacqueline

“…Deletion of all microRNAs (miRNAs) in nephron progenitors leads to premature loss of these cells, but the roles of specific miRNAs in progenitors have not been…”
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MicroRNAs: potential regulators of renal development genes that contribute to CAKUT by Marrone, April K., Ho, Jacqueline

“…Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of childhood chronic kidney disease (CKD). While mutations in several renal…”
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Food and Drug Administration insights on clinical study of weight‐loss devices intended for adolescent patients by Marrone, April K., Venkataraman‐Rao, Priya, Gottschalk, Laura

“…Summary Background Medical devices intended for weight loss may provide clinically meaningful benefit to children who are overweight and have obesity; however,…”
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miRNA-based buffering of the cobblestone–lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3′-UTR by Yatsenko, Andriy S., Marrone, April K., Shcherbata, Halyna R.

“…Many proteins are expressed dynamically during different stages of cellular life and the accuracy of protein amounts is critical for cell endurance. Therefore,…”
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Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors by Phua, Yu Leng, Chen, Kevin Hong, Hemker, Shelby L, Marrone, April K, Bodnar, Andrew J, Liu, Xiaoning, Clugston, Andrew, Kostka, Dennis, Butterworth, Michael B, Ho, Jacqueline

“…We have previously demonstrated that loss of in nephron progenitors in a mouse model results in renal hypodysplasia and chronic kidney disease. Clinically,…”
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The role for microRNAs in drug toxicity and in safety assessment by Marrone, April K, Beland, Frederick A, Pogribny, Igor P

“…Adverse drug reactions present significant challenges that impact pharmaceutical development and are major burdens to public health services worldwide. In…”
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Interventional Radiology Obesity Therapeutics: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel by Yuan, Frank, Latif, Muhammad A., Shafaat, Omid, Prologo, J. David, Hill, James O., Gudzune, Kimberly A., Marrone, April K., Kraitchman, Dara L., Rogers, Ann M., Khaitan, Leena, Oklu, Rahmi, Pereira, Keith, Steele, Kimberley, White, Sarah B., Weiss, Clifford R.

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MicroRNA changes, activation of progenitor cells and severity of liver injury in mice induced by choline and folate deficiency by Tryndyak, Volodymyr P., Marrone, April K., Latendresse, John R., Muskhelishvili, Levan, Beland, Frederick A., Pogribny, Igor P.

“…Dietary deficiency in methyl-group donors and cofactors induces liver injury that resembles many pathophysiological and histopathological features of human…”
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Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity by Marrone, April K, Beland, Frederick A, Pogribny, Igor P

“…Human exposure to certain environmental and occupational chemicals is one of the major risk factors for noncommunicable diseases, including cancer. Therefore,…”
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Stress and muscular dystrophy: A genetic screen for Dystroglycan and Dystrophin interactors in Drosophila identifies cellular stress response components by Kucherenko, Mariya M., Marrone, April K., Rishko, Valentyna M., Magliarelli, Helena de Fatima, Shcherbata, Halyna R.

“…In Drosophila, like in humans, Dystrophin Glycoprotein Complex (DGC) deficiencies cause a life span shortening disease, associated with muscle dysfunction. We…”
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Measurement of metabolic rate in Drosophila using respirometry by Yatsenko, Andriy S, Marrone, April K, Kucherenko, Mariya M, Shcherbata, Halyna R

“…Metabolic disorders are a frequent problem affecting human health. Therefore, understanding the mechanisms that regulate metabolism is a crucial scientific…”
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Paraffin-Embedded and Frozen Sections of Drosophila Adult Muscles by Kucherenko, Mariya M., Marrone, April K., Rishko, Valentyna M., Yatsenko, Andriy S., Klepzig, Annekatrin, Shcherbata, Halyna R.

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Research: Fluorescence Microscopy-Based Protocol for Detecting Residual Bacteria on Medical Devices by Wong, Michael, Wang, Yi, Wang, Hao, Marrone, April K, Haugen, Shanil P, Kulkarni, Kaumudi, Basile, Ralph, Phillips, K Scott

“…Standard methods are needed to reliably and efficiently assess bacterial contamination of processed medical devices. This article demonstrates a standard…”
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Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice by Marrone, April K., Shpyleva, Svitlana, Chappell, Grace, Tryndyak, Volodymyr, Uehara, Takeki, Tsuchiya, Masato, Beland, Frederick A., Rusyn, Ivan, Pogribny, Igor P.

“…Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers, with a rising incidence worldwide. The molecular mechanisms associated with the…”
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Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival by Phua, Yu Leng, Chu, Jessica Y. S., Marrone, April K., Bodnar, Andrew J., Sims‐Lucas, Sunder, Ho, Jacqueline

“…MicroRNAs are small noncoding RNAs that post‐transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in…”
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