Search Results - "Marrella, Veronica"

Cellular Senescence in Immunity against Infections by Marrella, Veronica, Facoetti, Amanda, Cassani, Barbara

“…Cellular senescence is characterized by irreversible cell cycle arrest in response to different triggers and an inflammatory secretome. Although originally…”
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Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair by Marrella, Veronica, Nicchiotti, Federico, Cassani, Barbara

“…Bacterial and viral respiratory tract infections are the most common infectious diseases, leading to worldwide morbidity and mortality. In the past 10 years,…”
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B lymphocytes limit senescence‐driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury by Faggioli, Francesca, Palagano, Eleonora, Di Tommaso, Luca, Donadon, Matteo, Marrella, Veronica, Recordati, Camilla, Mantero, Stefano, Villa, Anna, Vezzoni, Paolo, Cassani, Barbara

“…Hepatocellular carcinoma (HCC) is a frequent neoplasia and a leading cause of inflammation‐related cancer mortality. Despite that most HCCs arise from…”
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Human Peripheral Lymphoid Tissues Contain Autoimmune Regulator-Expressing Dendritic Cells by Poliani, Pietro Luigi, Kisand, Kai, Marrella, Veronica, Ravanini, Maria, Notarangelo, Luigi Daniele, Villa, Anna, Peterson, Pärt, Facchetti, Fabio

“…Autoimmune regulator (AIRE) modulates the expression of tissue-restricted antigens (TSAs) and promotes central tolerance in the thymus. However, few…”
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The role of WNT and IL-1 signaling in osteoarthritis: therapeutic implications for platelet-rich plasma therapy by Tonutti, Antonio, Granata, Valentina, Marrella, Veronica, Sobacchi, Cristina, Ragusa, Rita, Sconza, Cristiano, Rani, Nicola, Di Matteo, Berardo, Ceribelli, Angela

“…Different from inflammatory arthritis, where biologicals and targeted synthetic molecules have revolutionized the disease course, no drug has demonstrated a…”
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Defect of regulatory T cells in patients with Omenn syndrome by Cassani, Barbara, PhD, Poliani, Pietro Luigi, MD, PhD, Moratto, Daniele, PhD, Sobacchi, Cristina, PhD, Marrella, Veronica, PhD, Imperatori, Laura, PhD, Vairo, Donatella, PhD, Plebani, Alessandro, MD, Giliani, Silvia, PhD, Vezzoni, Paolo, MD, Facchetti, Fabio, MD, PhD, Porta, Fulvio, MD, Notarangelo, Luigi D., MD, Villa, Anna, MD, Badolato, Raffaele, MD, PhD

“…Background Omenn syndrome (OS) is an autosomal-recessive disorder characterized by severe immunodeficiency and T-cell–mediated autoimmunity. The disease is…”
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Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome by Cassani, Barbara, Poliani, Pietro Luigi, Marrella, Veronica, Schena, Francesca, Sauer, Aisha V, Ravanini, Maria, Strina, Dario, Busse, Christian E, Regenass, Stephan, Wardemann, Hedda, Martini, Alberto, Facchetti, Fabio, van der Burg, Mirjam, Rolink, Antonius G, Vezzoni, Paolo, Grassi, Fabio, Traggiai, Elisabetta, Villa, Anna

“…Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with…”
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A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome by Marrella, Veronica, Poliani, Pietro Luigi, Casati, Anna, Rucci, Francesca, Frascoli, Laura, Gougeon, Marie-Lise, Lemercier, Brigitte, Bosticardo, Marita, Ravanini, Maria, Battaglia, Manuela, Roncarolo, Maria Grazia, Cavazzana-Calvo, Marina, Facchetti, Fabio, Notarangelo, Luigi D, Vezzoni, Paolo, Grassi, Fabio, Villa, Anna

“…Rag enzymes are the main players in V(D)J recombination, the process responsible for rearrangement of TCR and Ig genes. Hypomorphic Rag mutations in humans,…”
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Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration by Maina, Virginia, Marrella, Veronica, Mantero, Stefano, Cassani, Barbara, Fontana, Elena, Anselmo, Achille, Del Prete, Annalisa, Sozzani, Silvano, Vezzoni, Paolo, Poliani, Pietro Luigi, Villa, Anna

“…In Omenn syndrome, altered dendritic cell distribution and impaired migration represent an additional level of immune dysregulation, contributing to the…”
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C1-inhibitor protects against brain ischemia–reperfusion injury via inhibition of cell recruitment and inflammation by Storini, Claudio, Rossi, Emanuela, Marrella, Veronica, Distaso, Maria, Veerhuis, Robert, Vergani, Carlo, Bergamaschini, Luigi, De Simoni, Maria-Grazia

“…Previous studies demonstrated that C1-inhibitor (C1-INH), a complement and contact-kinin systems inhibitor, is neuroprotective in cerebral ischemia. To…”
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Damaging‐agent sensitivity of Artemis‐deficient cell lines by Musio, Antonio, Marrella, Veronica, Sobacchi, Cristina, Rucci, Francesca, Fariselli, Laura, Giliani, Silvia, Lanzi, Gaetana, Notarangelo, Luigi D., Delia, Domenico, Colombo, Roberto, Vezzoni, Paolo, Villa, Anna

“…Defects in repairing double‐strand breaks can lead to genome instability and tumorigenesis. In humans, most T–B– severe combined immunodeficiencies (SCID) have…”
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Tissue-specific sensitivity to AID expression in transgenic mouse models by Rucci, Francesca, Cattaneo, Leonardo, Marrella, Veronica, Sacco, Maria Grazia, Sobacchi, Cristina, Lucchini, Franco, Nicola, Stefania, Bella, Silvia Della, Villa, Maria Luisa, Imberti, Luisa, Gentili, Francesca, Montagna, Cristina, Tiveron, Cecilia, Tatangelo, Laura, Facchetti, Fabio, Vezzoni, Paolo, Villa, Anna

“…Activation-induced cytidine deaminase (AID), an enzyme with homology to members of the APOBEC family, is involved in somatic hypermutation (SHM) of…”
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Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis by Garbarino, Ombretta, Lambroia, Luca, Basso, Gianluca, Marrella, Veronica, Franceschini, Barbara, Soldani, Cristiana, Pasqualini, Fabio, Giuliano, Desiree, Costa, Guido, Peano, Clelia, Barbarossa, Davide, Annarita, Destro, Salvati, Andreina, Terracciano, Luigi, Torzilli, Guido, Donadon, Matteo, Faggioli, Francesca

“…Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells accumulate in CRC favoring tumor dissemination. Whether this…”
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RAG-dependent primary immunodeficiencies by Sobacchi, Cristina, Marrella, Veronica, Rucci, Francesca, Vezzoni, Paolo, Villa, Anna

“…Mutations in recombination activating genes 1 and 2 (RAG1 and RAG2) cause a spectrum of severe immunodeficiencies ranging from classical T cell–B cell–severe…”
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Featured Cover by Garbarino, Ombretta, Lambroia, Luca, Basso, Gianluca, Marrella, Veronica, Franceschini, Barbara, Soldani, Cristiana, Pasqualini, Fabio, Giuliano, Desiree, Costa, Guido, Peano, Clelia, Barbarossa, Davide, Annarita, Destro, Salvati, Andreina, Terracciano, Luigi, Torzilli, Guido, Donadon, Matteo, Faggioli, Francesca

“…Cover legend: The cover image is based on the Research Article Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis by…”
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Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome by Rigoni, Rosita, Fontana, Elena, Dobbs, Kerry, Marrella, Veronica, Taverniti, Valentina, Maina, Virginia, Facoetti, Amanda, D’Amico, Giovanna, Al-Herz, Waleed, Cruz-Munoz, Mario Ernesto, Schuetz, Catharina, Gennery, Andrew R., Garabedian, Elizabeth K., Giliani, Silvia, Draper, Deborah, Dbaibo, Ghassan, Geha, Raif S., Meyts, Isabelle, Tousseyn, Thomas, Neven, Benedicte, Moshous, Despina, Fischer, Alain, Schulz, Ansgar, Finocchi, Andrea, Kuhns, Douglas B., Fink, Danielle L., Lionakis, Michail S., Swamydas, Muthulekha, Guglielmetti, Simone, Alejo, Julie, Myles, Ian A., Pittaluga, Stefania, Notarangelo, Luigi D., Villa, Anna, Cassani, Barbara

“…Severe early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn syndrome…”
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Omenn syndrome does not live by V(D)J recombination alone by Marrella, Veronica, Maina, Virginia, Villa, Anna

“…PURPOSE OF REVIEWDuring the past decade, easy access to sequence analyses has allowed us to increase our understanding of the pathogenesis of severe combined…”
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Osteopetrosis rescue upon RANKL administration to Rankl−/− mice: A new therapy for human RANKL-dependent ARO by Lo Iacono, Nadia, Blair, Harry C, Poliani, Pietro L, Marrella, Veronica, Ficara, Francesca, Cassani, Barbara, Facchetti, Fabio, Fontana, Elena, Guerrini, Matteo M, Traggiai, Elisabetta, Schena, Francesca, Paulis, Marianna, Mantero, Stefano, Inforzato, Antonio, Valaperta, Serenella, Pangrazio, Alessandra, Crisafulli, Laura, Maina, Virginia, Kostenuik, Paul, Vezzoni, Paolo, Villa, Anna, Sobacchi, Cristina

“…In the last decades the molecular basis of monogenic diseases has been largely unraveled, although their treatment has often remained unsatisfactory. Autosomal…”
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RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations by Pangrazio, Alessandra, Cassani, Barbara, Guerrini, Matteo M, Crockett, Julie C, Marrella, Veronica, Zammataro, Luca, Strina, Dario, Schulz, Ansgar, Schlack, Claire, Kornak, Uwe, Mellis, David J, Duthie, Angela, Helfrich, Miep H, Durandy, Anne, Moshous, Despina, Vellodi, Ashok, Chiesa, Robert, Veys, Paul, Lo Iacono, Nadia, Vezzoni, Paolo, Fischer, Alain, Villa, Anna, Sobacchi, Cristina

“…Autosomal recessive osteopetrosis (ARO) is a genetically heterogeneous disorder attributed to reduced bone resorption by osteoclasts. Most human AROs are…”
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IL-10 critically modulates B cell responsiveness in Rankl-/- mice by Marrella, Veronica, Lo Iacono, Nadia, Fontana, Elena, Sobacchi, Cristina, Sic, Heiko, Schena, Francesca, Sereni, Lucia, Castiello, Maria Carmina, Poliani, Pietro Luigi, Vezzoni, Paolo, Cassani, Barbara, Traggiai, Elisabetta, Villa, Anna

“…The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context,…”
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