Search Results - "Maroun, R. C."

The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase by Maroun, Christiane R., Naujokas, Monica A., Holgado-Madruga, Marina, Wong, Albert J., Park, Morag

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Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved by Serrano, Solange M.T., Maroun, Rachid C.

“…Snake venom glands synthesize a variety of serine proteinases capable of affecting the haemostatic system. They act on macromolecular substrates of the…”
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Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen by Newell, M. Karen, Haughn, Lori J, Maroun, Christiane R, Julius, Michael H

“…Effector T cells are restricted to recognizing antigens associated with major histocompatibility complex (MHC) molecules. Specific recognition is mediated by…”
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Identification of the substrate-binding exosites of two snake venom serine proteinases: molecular basis for the partition of two essential functions of thrombin by Maroun, R. C., Serrano, S. M. T.

“…The venom of the South American snake Bothrops jararaca contains two serine proteinases, bothrombin and the platelet‐aggregating enzyme PA‐BJ, which share 66%…”
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Distinct roles for CD4 and CD8 as co-receptors in T cell receptor signalling by Maroun, C R, Julius, M

“…We demonstrate that CD4 and CD8 modify signals induced through the T cell receptor for antigen (TCR alpha beta) in distinct fashions. Pretreatment of CD4+…”
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Distinct involvement of CD45 in antigen receptor signalling in CD4+ and CD8+ primary T cells by Maroun, C R, Julius, M

“…We demonstrate that pretreatment of primary CD4+, but not CD8+ T cells with anti-CD45 inhibits activation signals induced through the T cell receptor for…”
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The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase by Maroun, Christiane R., Holgado-Madruga, Marina, Royal, Isabelle, Naujokas, Monica A., Fournier, Tanya M., Wong, Albert J., Park, Morag

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Toxicity evolution of Vipera aspis aspis venom: identification and molecular modeling of a novel phospholipase A(2) heterodimer neurotoxin by Jan, Virginie, Maroun, R C, Robbe-Vincent, Annie, De Haro, Luc, Choumet, Valérie

“…We report the simultaneous presence of two phospholipase A(2) (PLA(2)) neurotoxins in the venom of Vipera aspis aspis, the first such observation. One is…”
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A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis by Maroun, Christiane R., Moscatello, David K., Naujokas, Monica A., Holgado-Madruga, Marina, Wong, Albert J., Park, Morag

“…Stimulation of the hepatocyte growth factor receptor tyrosine kinase, Met, induces the inherent morphogenic program of epithelial cells. The multisubstrate…”
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Induction of DNA bending by bifunctional intercalating agents of the 7H-pyridocarbazole family by Maroun, R C, Roques, B P

“…The structures and binding energetics of selected complexes formed between the deoxynucleotides d(CpGpGpCpG).d(CpGpCpCpG), d(CpGpApTpCpG)2,…”
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Molecular basis for the partition of the essential functions of thrombin among snake venom serine proteinases: the case of thrombin-like enzymes by Maroun, R C

“…Thrombin is a mammalian serine proteinase that plays a prominent role in the maintenance and regulation of hemostasis through its interaction with various…”
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The Gab1 Docking Protein Links the B Cell Antigen Receptor to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and to the SHP2 Tyrosine Phosphatase by Ingham, Robert J., Santos, Lorna, Dang-Lawson, May, Holgado-Madruga, Marina, Dudek, Peter, Maroun, Christiane R., Wong, Albert J., Matsuuchi, Linda, Gold, Michael R.

“…B cell antigen receptor (BCR) signaling causes tyrosine phosphorylation of the Gab1 docking protein. This allows phosphatidylinositol 3-kinase (PI3K) and the…”
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Structural Basis of the gp120 Superantigen-Binding Site on Human Immunoglobulins by Karray, Saoussen, Juompan, Laure, Maroun, Rachid C, Isenberg, David, Silverman, Gregg J, Zouali, Moncef

“…B cell superantigens (SAg) interact with normal human nonimmune Igs (Igs), independently of the light chain isotype, and activate a large proportion of the B…”
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Entamoeba histolytica: inhibition of cellular functions by overexpression of EhGEF1, a novel Rho/Rac guanine nucleotide exchange factor by Aguilar-Rojas, Arturo, Almaraz-Barrera, Ma. de Jesús, Krzeminski, Mickaël, Robles-Flores, Martha, Hernández-Rivas, Rosaura, Guillén, Nancy, Maroun, Rachid C., Vargas, Miguel

“…The molecular, biochemical, and cellular characterization of EhGEF1 protein is described. Complete cDNA sequence of 1890 bp revealed an open reading frame that…”
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Trimeresurus stejnegeri snake venom plasminogen activator. Site-directed mutagenesis and molecular modeling by Zhang, Y, Wisner, A, Maroun, R C, Choumet, V, Xiong, Y, Bon, C

“…The specific plasminogen activator from Trimeresurus stejnegeri venom (TSV-PA) is a serine proteinase presenting 23% sequence identity with the proteinase…”
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Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion by Fournier, T M, Lamorte, L, Maroun, C R, Lupher, M, Band, H, Langdon, W, Park, M

“…Dispersal of epithelial cells is an important aspect of tumorigenesis, and invasion. Factors such as hepatocyte growth factor induce the breakdown of cell…”
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Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling by Julius, M, Maroun, C R, Haughn, L

“…The co-ordinated interactions of multiple membrane molecules with the T-cell receptor for antigen (the TCR-CD3) are prerequisite for T-cell activation. In this…”
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Physical Association of CD4 and CD45 in Primary, Resting CD4+T Cells by Bonnard, Madeleine, Maroun, Christiane R., Julius, Michael

“…CD45 is a family of transmembrane protein tyrosine phosphatases that are essential to T lymphocytes’ responses to antigen–receptor stimulation. It is involved…”
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Molecular Modeling of an Active Loop Structure in Lysozyme. Sequence Effects or Crystal Packing? by Maroun, Rachid C.

“…The Val99-Glyl04 variable region in egg white lysozyme is part of the active site cleft and of the epitope recognized by some monoclonal antibodies. In…”
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Identification and molecular structural prediction analysis of a toxicity determinant in the Bacillus sphaericus crystal larvicidal toxin by Yuan, Zhiming, Rang, Cécile, Maroun, Rachid C., Juárez‐Pérez, Victor, Frutos, Roger, Pasteur, Nicole, Vendrely, Charlotte, Charles, Jean‐François, Nielsen‐LeRoux, Christina

“…The operon containing the genes encoding the subunits of the binary crystal toxin of Bacillus sphaericus strain LP1‐G, BinA and BinB (41.9 kDa and 51.4 kDa,…”
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