Search Results - "Marosi, Krisztina"

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting by Anton, Stephen D., Moehl, Keelin, Donahoo, William T., Marosi, Krisztina, Lee, Stephanie A., Mainous, Arch G., Leeuwenburgh, Christiaan, Mattson, Mark P.

“…Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can…”
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3‐Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons by Marosi, Krisztina, Kim, Sang Woo, Moehl, Keelin, Scheibye‐Knudsen, Morten, Cheng, Aiwu, Cutler, Roy, Camandola, Simonetta, Mattson, Mark P.

“…During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from glucose to the ketone 3‐hydroxybutyrate (3OHB) occurs. Studies…”
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DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya by Geisler, John G, Marosi, Krisztina, Halpern, Joshua, Mattson, Mark P

“…Abstract Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative…”
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway by Fang, Evandro F., Waltz, Tyler B., Kassahun, Henok, Lu, Qiping, Kerr, Jesse S., Morevati, Marya, Fivenson, Elayne M., Wollman, Bradley N., Marosi, Krisztina, Wilson, Mark A., Iser, Wendy B., Eckley, D. Mark, Zhang, Yongqing, Lehrmann, Elin, Goldberg, Ilya G., Scheibye-Knudsen, Morten, Mattson, Mark P., Nilsen, Hilde, Bohr, Vilhelm A., Becker, Kevin G.

“…Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health of older…”
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Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA by Scheibye-Knudsen, Morten, Tseng, Anne, Jensen, Martin Borch, Scheibye-Alsing, Karsten, Fang, Evandro Fei, Iyama, Teruaki, Bharti, Sanjay Kumar, Marosi, Krisztina, Froetscher, Lynn, Kassahun, Henok, Eckley, David Mark, Maul, Robert W., Bastian, Paul, De, Supriyo, Ghosh, Soumita, Nilsen, Hilde, Goldberg, Ilya G., Mattson, Mark P., Wilson, David M., Brosh, Robert M., Gorospe, Myriam, Bohr, Vilhelm A.

“…Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although the pathogenesis of Cockayne syndrome…”
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A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson’s disease by Kishimoto, Yuki, Johnson, Joshua, Fang, William, Halpern, Joshua, Marosi, Krisztina, Liu, Dong, Geisler, John G., Mattson, Mark P.

“…Dopaminergic neuronal cell loss in the substantia nigra is responsible for the motor symptoms that are the clinical hallmark of Parkinson’s disease (PD). As of…”
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Prescribing cholinesterase inhibitors in mild cognitive impairment—Observations from the Alzheimer's Disease Neuroimaging Initiative by Stage, Eddie, Svaldi, Diana, Sokolow, Sophie, Risacher, Shannon L., Marosi, Krisztina, Rotter, Jerome I., Saykin, Andrew J., Apostolova, Liana G.

“…Introduction Analyses of off‐label use of acetylcholinesterase inhibitors (AChEIs) in mild cognitive impairment (MCI) has produced mixed results. Post hoc…”
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Cardiac Index by Transthoracic Echocardiography (CITE) study by Szabó, Barna, Marosi, Eszter Krisztina, Vargová, Katarina, Nyolczas, Noémi

“…Left ventricular ejection fraction (LVEF) is the most frequently used parameter in the assessment of heart failure (HF). Cardiac index (CI) is considered a…”
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BDNF mediates adaptive brain and body responses to energetic challenges by Marosi, Krisztina, Mattson, Mark P

“…Highlights • Energetic challenges (e.g., exercise and energy restriction) induce BDNF signaling. • BDNF enhances neuronal bioenergetics and promotes optimal…”
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Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges by Cheng, Aiwu, Yang, Ying, Zhou, Ye, Maharana, Chinmoyee, Lu, Daoyuan, Peng, Wei, Liu, Yong, Wan, Ruiqian, Marosi, Krisztina, Misiak, Magdalena, Bohr, Vilhelm A., Mattson, Mark P.

“…The impact of mitochondrial protein acetylation status on neuronal function and vulnerability to neurological disorders is unknown. Here we show that the…”
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Ketone beta-hydroxybutyrate up-regulates BDNF expression through NF-κB as an adaptive response against ROS, which may improve neuronal bioenergetics and enhance neuroprotection (P3.090) by Kim, Sang Woo, Marosi, Krisztina, Mattson, Mark

“…Abstract only…”
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Exercise and BDNF reduce Aβ production by enhancing α‐secretase processing of APP by Nigam, Saket M., Xu, Shaohua, Kritikou, Joanna S., Marosi, Krisztina, Brodin, Lennart, Mattson, Mark P.

“…Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterized by aggregation of toxic forms of amyloid β peptide (Aβ). Treatment…”
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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair by Fang, Evandro Fei, Kassahun, Henok, Croteau, Deborah L., Scheibye-Knudsen, Morten, Marosi, Krisztina, Lu, Huiming, Shamanna, Raghavendra A., Kalyanasundaram, Sumana, Bollineni, Ravi Chand, Wilson, Mark A., Iser, Wendy B., Wollman, Bradley N., Morevati, Marya, Li, Jun, Kerr, Jesse S., Lu, Qiping, Waltz, Tyler B., Tian, Jane, Sinclair, David A., Mattson, Mark P., Nilsen, Hilde, Bohr, Vilhelm A.

“…Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive neurodegeneration and cerebellar ataxia. A-T is causally linked…”
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Metabolic and molecular framework for the enhancement of endurance by intermittent food deprivation by Marosi, Krisztina, Moehl, Keelin, Navas‐Enamorado, Ignacio, Mitchell, Sarah J., Zhang, Yongqing, Lehrmann, Elin, Aon, Miguel A., Cortassa, Sonia, Becker, Kevin G., Mattson, Mark P.

“…Evolutionary considerations suggest that the body has been optimized to perform at a high level in the food‐deprived state when fatty acids and their ketone…”
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Target discovery using biobanks and human genetics by Hicks, Michael A., Hou, Claire Y.C., Iranmehr, Arya, Marosi, Krisztina, Kirkness, Ewen

“…[Display omitted] •Genetic data enhance the approval rate of new therapeutics.•Protective loss-of-function variants offer attractive therapeutic…”
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Exercise and BDNF reduce A[beta] production by enhancing [alpha]-secretase processing of APP by Nigam, Saket M, Xu, Shaohua, Kritikou, Joanna S, Marosi, Krisztina, Brodin, Lennart, Mattson, Mark P

“…Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by aggregation of toxic forms of amyloid [beta] peptide (A[beta])…”
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Hold the Salt: Vasopressor Role for BDNF by Marosi, Krisztina, Mattson, Mark P.

“…In a recent publication in Neuron, Choe et al. (2015) demonstrate that brain-derived neurotrophic factor (BDNF) signaling mediates salt-induced blood pressure…”
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ACETYLCHOLINESTERASE INHIBITOR THERAPY IN MILD COGNITIVE IMPAIRMENT: YES OR NO? by Sokolow, Sophie, Marosi, Krisztina, Nho, Kwangsik, Rotter, Jerome I., Apostolova, Liana G., Neuroimaging Initiative, Alzheimer’s Disease

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P2‐003: ACETYLCHOLINESTERASE INHIBITOR THERAPY IN MILD COGNITIVE IMPAIRMENT: YES OR NO? by Sokolow, Sophie, Marosi, Krisztina, Nho, Kwangsik, Rotter, Jerome I., Apostolova, Liana G.

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Increased stability of S-nitrosothiol solutions via pH modulations by Hornyák, István, Marosi, Krisztina, Kiss, Levente, Gróf, Pál, Lacza, Zsombor

“…S-nitrosothiol (RSNO) solutions represent a valuable source of nitric oxide and could be used as topical vasodilators, but their fast decomposition rate poses…”
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