Search Results - "Marnett, Lawrence J."

Cyclooxygenases: structural and functional insights by Rouzer, Carol A., Marnett, Lawrence J.

“…Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms…”
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Inflammation and Cancer: Chemical Approaches to Mechanisms, Imaging, and Treatment by Marnett, Lawrence J

“…The inflammatory response represents a first line of defense against invading pathogens and is important to human health. Chronic inflammation contributes to…”
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Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks by Galligan, James J., Wepy, James A., Streeter, Matthew D., Kingsley, Philip J., Mitchener, Michelle M., Wauchope, Orrette R., Beavers, William N., Rose, Kristie L., Wang, Tina, Spiegel, David A., Marnett, Lawrence J.

“…Histone posttranslational modifications (PTMs) regulate chromatin dynamics, DNA accessibility, and transcription to expand the genetic code. Many of these PTMs…”
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Oxicams, a class of nonsteroidal anti‐inflammatory drugs and beyond by Xu, Shu, Rouzer, Carol A., Marnett, Lawrence J.

“…Oxicams are a class of nonsteroidal anti‐inflammatory drugs (NSAIDs) structurally related to the enolic acid class of 4‐hydroxy‐1,2‐benzothiazine carboxamides…”
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HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins by Jacobs, Aaron T., Marnett, Lawrence J.

“…4-Hydroxynonenal (HNE) is a pro-apoptotic electrophile generated during the spontaneous decomposition of oxidized lipids. We have previously shown that HNE…”
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Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation by Hermanson, Daniel J, Gamble-George, Joyonna C, Marnett, Lawrence J, Patel, Sachin

“…Highlights • Endocannabinoid augmentation may have broad therapeutic implications. • COX-2 is a third endocannabinoid metabolic mechanism. •…”
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Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation by Shonesy, Brian C, Bluett, Rebecca J, Ramikie, Teniel S, Báldi, Rita, Hermanson, Daniel J, Kingsley, Philip J, Marnett, Lawrence J, Winder, Danny G, Colbran, Roger J, Patel, Sachin

“…Endocannabinoid (eCB) signaling has been heavily implicated in the modulation of anxiety and depressive behaviors and emotional learning. However, the role of…”
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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release by Foster, Daniel J., Wilson, Jermaine M., Remke, Daniel H., Mahmood, M. Suhaib, Uddin, M. Jashim, Wess, Jürgen, Patel, Sachin, Marnett, Lawrence J., Niswender, Colleen M., Jones, Carrie K., Xiang, Zixiu, Lindsley, Craig W., Rook, Jerri M., Conn, P. Jeffrey

“…Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the mechanisms underlying the antipsychotic efficacy of muscarinic…”
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Structural and Functional Basis of Cyclooxygenase Inhibition by Blobaum, Anna L, Marnett, Lawrence J

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Endocannabinoid signalling modulates susceptibility to traumatic stress exposure by Bluett, Rebecca J., Báldi, Rita, Haymer, Andre, Gaulden, Andrew D., Hartley, Nolan D., Parrish, Walker P., Baechle, Jordan, Marcus, David J., Mardam-Bey, Ramzi, Shonesy, Brian C., Uddin, Md. Jashim, Marnett, Lawrence J., Mackie, Ken, Colbran, Roger J., Winder, Danny G., Patel, Sachin

“…Stress is a ubiquitous risk factor for the exacerbation and development of affective disorders including major depression and posttraumatic stress disorder…”
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In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity by Farrell, Jordan S, Colangeli, Roberto, Dong, Ao, George, Antis G, Addo-Osafo, Kwaku, Kingsley, Philip J, Morena, Maria, Wolff, Marshal D, Dudok, Barna, He, Kaikai, Patrick, Toni A, Sharkey, Keith A, Patel, Sachin, Marnett, Lawrence J, Hill, Matthew N, Li, Yulong, Teskey, G Campbell, Soltesz, Ivan

“…The brain's endocannabinoid system is a powerful controller of neurotransmitter release, shaping synaptic communication under physiological and pathological…”
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Stable Histone Adduction by 4‑Oxo-2-nonenal: A Potential Link between Oxidative Stress and Epigenetics by Galligan, James J, Rose, Kristie L, Beavers, William N, Hill, Salisha, Tallman, Keri A, Tansey, William P, Marnett, Lawrence J

“…Lipid electrophiles modify cellular targets, altering their function. Here, we describe histones as major targets for modification by 4-oxo-2-nonenal,…”
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Temporal dissociation of COX-2-dependent arachidonic acid and 2-arachidonoylglycerol metabolism in RAW264.7 macrophages by Aleem, Ansari M., Mitchener, Michelle M., Kingsley, Philip J., Rouzer, Carol A., Marnett, Lawrence J.

“…Cyclooxygenase-2 converts arachidonic acid to prostaglandins (PGs) and the endocannabinoid, 2-arachidonoylglycerol (2-AG), to PG glyceryl esters (PG-Gs). The…”
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Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen by Duggan, Kelsey C., Walters, Matthew J., Musee, Joel, Harp, Joel M., Kiefer, James R., Oates, John A., Marnett, Lawrence J.

“…Naproxen ((S)-6-methoxy-α-methyl-2-naphthaleneacetic acid) is a powerful non-selective non-steroidal anti-inflammatory drug that is extensively used as a…”
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Introduction to Lipid Biochemistry, Metabolism, and Signaling by Brown, H Alex, Marnett, Lawrence J

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Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors by Bedse, Gaurav, Bluett, Rebecca J., Patrick, Toni A., Romness, Nicole K., Gaulden, Andrew D., Kingsley, Philip J., Plath, Niels, Marnett, Lawrence J., Patel, Sachin

“…Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models…”
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Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network by Xu, Shu, Hermanson, Daniel J., Banerjee, Surajit, Ghebreselasie, Kebreab, Clayton, Gina M., Garavito, R. Michael, Marnett, Lawrence J.

“…Oxicams are widely used nonsteroidal anti-inflammatory drugs (NSAIDs), but little is known about the molecular basis of the interaction with their target…”
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Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling[S] by Wepy, James A., Galligan, James J., Kingsley, Philip J., Xu, Shu, Goodman, Michael C., Tallman, Keri A., Rouzer, Carol A., Marnett, Lawrence J.

“…Lysophospholipids (LysoPLs) are bioactive lipid species involved in cellular signaling processes and the regulation of cell membrane structure. LysoPLs are…”
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Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses by Ullery, Jody C., Marnett, Lawrence J.

“…Oxygen is essential for the growth and function of mammalian cells. However, imbalances in oxygen or abnormalities in the ability of a cell to respond to…”
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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation by Hermanson, Daniel J, Hartley, Nolan D, Gamble-George, Joyonna, Brown, Naoko, Shonesy, Brian C, Kingsley, Phillip J, Colbran, Roger J, Reese, Jeffrey, Marnett, Lawrence J, Patel, Sachin

“…Enhancing endocannabinoid signaling is a potential therapeutic approach to treating anxiety disorders. Here the authors show that a compound leading to…”
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