Search Results - "Marlies Knipper"

Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons by Gross, Johann, Knipper, Marlies, Mazurek, Birgit

“…To study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard…”
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Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis by Knipper, Marlies, Van Dijk, Pim, Nunes, Isidro, Rüttiger, Lukas, Zimmermann, Ulrike

“…The prevalence of hearing problems in the Western world has, due to aging of the population, doubled over the past 30 years. Thereby, noise-induced hearing…”
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Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway by Peixoto Pinheiro, Barbara, Vona, Barbara, Löwenheim, Hubert, Rüttiger, Lukas, Knipper, Marlies, Adel, Youssef

“…Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly and constitutes the third highest risk factor for dementia. Lifetime noise…”
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Functional significance of channels and transporters expressed in the inner ear and kidney by Lang, Florian, Vallon, Volker, Knipper, Marlies, Wangemann, Philine

“…A number of ion channels and transporters are expressed in both the inner ear and kidney. In the inner ear, K(+) cycling and endolymphatic K(+), Na(+), Ca(2+),…”
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Too Blind to See the Elephant? Why Neuroscientists Ought to Be Interested in Tinnitus by Knipper, Marlies, Mazurek, Birgit, van Dijk, Pim, Schulze, Holger

“…A curative therapy for tinnitus currently does not exist. One may actually exist but cannot currently be causally linked to tinnitus due to the lack of…”
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The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats by Rüttiger, Lukas, Singer, Wibke, Panford-Walsh, Rama, Matsumoto, Masahiro, Lee, Sze Chim, Zuccotti, Annalisa, Zimmermann, Ulrike, Jaumann, Mirko, Rohbock, Karin, Xiong, Hao, Knipper, Marlies

“…Tinnitus is proposed to be caused by decreased central input from the cochlea, followed by increased spontaneous and evoked subcortical activity that is…”
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Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus by Gross, Johann, Knipper, Marlies, Mazurek, Birgit

“…The aim of this study was to identify key proteins of synaptic transmission in the cochlear nucleus (CN) that are involved in normal hearing, acoustic…”
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Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction by Chen, Jeremy Tsung-chieh, Guo, Da, Campanelli, Dario, Frattini, Flavia, Mayer, Florian, Zhou, Luming, Kuner, Rohini, Heppenstall, Paul A., Knipper, Marlies, Hu, Jing

“…The gate control theory proposes the importance of both pre- and post-synaptic inhibition in processing pain signal in the spinal cord. However, although…”
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The glucocorticoid antagonist mifepristone attenuates sound‐induced long‐term deficits in auditory nerve response and central auditory processing in female rats by Singer, Wibke, Kasini, Kamyar, Manthey, Marie, Eckert, Philipp, Armbruster, Philipp, Vogt, Miriam Annika, Jaumann, Mirko, Dotta, Michela, Yamahara, Kohei, Harasztosi, Csaba, Zimmermann, Ulrike, Knipper, Marlies, Rüttiger, Lukas

“…ABSTRACT Systemic corticosteroids have been the mainstay of treatment for various hearing disorders for more than 30 yr. Accordingly, numerous studies have…”
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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells by Kros, Corné J, Marcotti, Walter, Johnson, Stuart L, Eckrich, Tobias, Kuhn, Stephanie, Zampini, Valeria, Franz, Christoph, Ranatunga, Kishani M, Roberts, Terri P, Masetto, Sergio, Knipper, Marlies

“…Johnson and colleagues investigate spiking activity in developing inner hair cells (IHCs), showing that apical IHCs fire spontaneous action potentials in a…”
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Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use by Ishikawa, Masaaki, García-Mateo, Nadia, Čusak, Alen, López-Hernández, Iris, Fernández-Martínez, Marta, Müller, Marcus, Rüttiger, Lukas, Singer, Wibke, Löwenheim, Hubert, Kosec, Gregor, Fujs, Štefan, Martínez-Martínez, Luis, Schimmang, Thomas, Petković, Hrvoje, Knipper, Marlies, Durán-Alonso, M. Beatriz

“…Spread of antimicrobial resistance and shortage of novel antibiotics have led to an urgent need for new antibacterials. Although aminoglycoside antibiotics…”
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Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells by Duncker, Susanne V, Franz, Christoph, Kuhn, Stephanie, Schulte, Uwe, Campanelli, Dario, Brandt, Niels, Hirt, Bernhard, Fakler, Bernd, Blin, Nikolaus, Ruth, Peter, Engel, Jutta, Marcotti, Walter, Zimmermann, Ulrike, Knipper, Marlies

“…The encoding of auditory information with indefatigable precision requires efficient resupply of vesicles at inner hair cell (IHC) ribbon synapses. Otoferlin,…”
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Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus by Hofmeier, Benedikt, Wolpert, Stephan, Aldamer, Ebrahim Saad, Walter, Moritz, Thiericke, John, Braun, Christoph, Zelle, Dennis, Rüttiger, Lukas, Klose, Uwe, Knipper, Marlies

“…The exact neurophysiological basis of chronic tinnitus, which affects 10-15% of the population, remains unknown and is controversial at many levels. It is an…”
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Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity by Johnson, Stuart L., Kuhn, Stephanie, Franz, Christoph, Ingham, Neil, Furness, David N., Knipper, Marlies, Steel, Karen P., Adelman, John P., Holley, Matthew C., Marcotti, Walter

“…The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian…”
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Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss by Peixoto Pinheiro, Barbara, Adel, Youssef, Knipper, Marlies, Müller, Marcus, Löwenheim, Hubert

“…Age-related hearing loss (ARHL) is the most common sensory deficit in aging society, which is accompanied by increased speech discrimination difficulties in…”
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Noise-Induced Inner Hair Cell Ribbon Loss Disturbs Central Arc Mobilization: A Novel Molecular Paradigm for Understanding Tinnitus by Singer, Wibke, Zuccotti, Annalisa, Jaumann, Mirko, Lee, Sze Chim, Panford-Walsh, Rama, Xiong, Hao, Zimmermann, Ulrike, Franz, Christoph, Geisler, Hyun-Soon, Köpschall, Iris, Rohbock, Karin, Varakina, Ksenya, Verpoorten, Sandrine, Reinbothe, Thomas, Schimmang, Thomas, Rüttiger, Lukas, Knipper, Marlies

“…Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis. Although both often coincide, a causal relationship between tinnitus…”
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Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition by Knipper, Marlies, Singer, Wibke, Schwabe, Kerstin, Hagberg, Gisela E, Li Hegner, Yiwen, Rüttiger, Lukas, Braun, Christoph, Land, Rüdiger

“…Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory activity is associated with numerous forms of hearing loss, including…”
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Tinnitus Research: Improvement and Innovation by Baguley, David M., van Dijk, Pim, Knipper, Marlies

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Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics by Wertz, Jakob, Rüttiger, Lukas, Bender, Benjamin, Klose, Uwe, Stark, Robert S, Dapper, Konrad, Saemisch, Jörg, Braun, Christoph, Singer, Wibke, Dalhoff, Ernst, Bader, Katharina, Wolpert, Stephan M, Knipper, Marlies, Munk, Matthias H J

“…The ongoing controversies about the neural basis of tinnitus, whether linked with central neural gain or not, may hamper efforts to develop therapies. We asked…”
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Co-occurrence of Hyperacusis Accelerates With Tinnitus Burden Over Time and Requires Medical Care by Refat, Fatma, Wertz, Jakob, Hinrichs, Pauline, Klose, Uwe, Samy, Hesham, Abdelkader, Rafeek Mohamed, Saemisch, Jörg, Hofmeier, Benedikt, Singer, Wibke, Rüttiger, Lukas, Knipper, Marlies, Wolpert, Stephan

“…Although tinnitus represents a major global burden, no causal therapy has yet been established. Ongoing controversies about the neuronal pathophysiology of…”
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