Search Results - "Marler, Ronald"

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation by Mills, Lisa D., Zhang, Yaqing, Marler, Ronald J., Herreros-Villanueva, Marta, Zhang, Lizhi, Almada, Luciana L., Couch, Fergus, Wetmore, Cynthia, Pasca di Magliano, Marina, Fernandez-Zapico, Martin E.

“…Although the biological role of KRAS is clearly established in carcinogenesis, the molecular mechanisms underlying this phenomenon are not completely…”
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EUS-guided portal injection chemotherapy for treatment of hepatic metastases: feasibility in the acute porcine model by Faigel, Douglas O., MD, FASGE, Lake, Douglas F., PhD, Landreth, Tracy L., BS, Kelman, Catherine C., BA, Marler, Ronald J., DVM, PhD

“…Background and Aims Direct injection of chemotherapy into the portal vein for treatment of liver metastases may increase hepatic tissue levels while decreasing…”
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Submucosal endoscopy with mucosal flap safety valve by Sumiyama, Kazuki, MD, PhD, Gostout, Christopher J., MD, Rajan, Elizabeth, MD, Bakken, Timothy A., LPN, Knipschield, Mary A, Marler, Ronald J., DVM, PhD

“…Background There is no reliable endoscopic method to selectively resect deeper layers of the gut wall or to access the peritoneal cavity and prevent peritoneal…”
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Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo by Helder, Meghana R.K., MD, Hennessy, Ryan S., MD, Spoon, Daniel B., MD, Tefft, Brandon J., PhD, Witt, Tyra A., CVT, Marler, Ronald J., DVM, PhD, Pislaru, Sorin V., MD, PhD, Simari, Robert D., MD, Stulak, John M., MD, Lerman, Amir, MD

“…Background Decellularized heart valves are emerging as a potential alternative to current bioprostheses for valve replacement. Whereas techniques of…”
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Longevity and Age-Related Pathology of Mice Deficient in Pregnancy-Associated Plasma Protein-A by Conover, Cheryl A., Bale, Laurie K., Mader, Jessica R., Mason, Megan A., Keenan, Kevin P., Marler, Ronald J.

“…The pregnancy-associated plasma protein-A knockout (PAPP-A KO) mouse is a model of reduced local insulin-like growth factor (IGF)-I activity with normal…”
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Pregnancy-associated plasma protein-A deficiency improves survival of mice on a high fat diet by Conover, Cheryl A., Bale, Laurie K., Marler, Ronald J.

“…Obesity is on the rise in westernized countries, and visceral obesity in particular is associated with enhanced risk of developing metabolic disease and…”
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Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1 by Elgilani, Faysal, Mao, Shennen A, Glorioso, Jaime M, Yin, Meng, Iankov, Ianko D, Singh, Anisha, Amiot, Bruce, Rinaldo, Piero, Marler, Ronald J, Ehman, Richard L, Grompe, Markus, Lillegard, Joseph B, Hickey, Raymond D, Nyberg, Scott L

“…Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by deficiency in fumarylacetoacetate hydrolase, the last enzyme in the tyrosine…”
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Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo by Radhakrishnan, Suresh, Cabrera, Rosalyn, Schenk, Erin L, Nava-Parada, Pilar, Bell, Michael P, Van Keulen, Virginia P, Marler, Ronald J, Felts, Sara J, Pease, Larry R

“…Lymphocyte differentiation from naive CD4(+) T cells into mature Th1, Th2, Th17, or T regulatory cell (Treg) phenotypes has been considered end stage in…”
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Skeletal and Uterotrophic Effects of Endoxifen in Female Rats by Gingery, Anne, Iwaniec, Urszula T, Subramaniam, Malayannan, Turner, Russell T, Pitel, Kevin S, McGovern, Renee M, Reid, Joel M, Marler, Ronald J, Ingle, James N, Goetz, Matthew P, Hawse, John R

“…Endoxifen, the primary active metabolite of tamoxifen, is currently being investigated as a novel endocrine therapy for the treatment of breast cancer…”
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Absence of Histologic Retinal Toxicity of Intravitreal Bevacizumab in a Rabbit Model by Bakri, Sophie J., Cameron, J. Douglas, McCannel, Colin A., Pulido, Jose S., Marler, Ronald J.

“…To evaluate the retinal toxicity of intravitreal bevacizumab in an animal model. Animal study. Bevacizumab was injected into the vitreous of one eye of each of…”
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Endoscopic band ligation for closure of GI perforations in a porcine animal model (with video) by Law, Ryan, DO, Deters, Jodie L., LPN, Miller, Charles A., LPN, Marler, Ronald J., DVM, PhD, Baron, Todd H., MD, FASGE

“…Background GI perforations occur rarely during endoscopy but have life-threatening implications. Objective To evaluate endoscopic band ligation (EBL) for…”
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Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy by Mader, Jessica R, Resch, Zachary T, McLean, Gary R, Mikkelsen, Jakob H, Oxvig, Claus, Marler, Ronald J, Conover, Cheryl A

“…We investigated pregnancy-associated plasma protein-A (PAPP-A) in diabetic nephropathy. Normal human kidney showed specific staining for PAPP-A in glomeruli,…”
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Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease by Hickey, Raymond D., Mao, Shennen A., Glorioso, Jaime, Lillegard, Joseph B., Fisher, James E., Amiot, Bruce, Rinaldo, Piero, Harding, Cary O., Marler, Ronald, Finegold, Milton J., Grompe, Markus, Nyberg, Scott L.

“…Hereditary tyrosinemia type I (HT1) is caused by deficiency in fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the last step of tyrosine…”
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Mo1924 Feasibility of EUS-Guided Portal Injection of Chemotherapy (EPIC) Using Irinotecan-Loaded Microbeads for the Treatment of Hepatic Metastases by Faigel, Douglas O, Lake, Douglas, Landreth, Tracy L, Kelman, Catherine C, Marler, Ronald J

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Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model by Bakri, Sophie J, Pulido, Jose S, Mukherjee, Priyabata, Marler, Ronald J, Mukhopadhyay, Debabrata

“…To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent. One eye of each of 16 Dutch-belted rabbits was…”
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Downregulation of Hematopoietic MUC1 during Experimental Colitis Increases Tumor-Promoting Myeloid-Derived Suppressor Cells by WEI POH, Tze, MADSEN, Cathy S, GORMAN, Jessica E, MARLER, Ronald J, LEIGHTON, Jonathan A, COHEN, Peter A, GENDLER, Sandra J

“…MUC1 is a tumor-associated antigen that is aberrantly expressed in cancer and inflammatory bowel disease (IBD). Even though immune cells express low MUC1…”
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Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion by Katayama, Minako, Jiamsripong, Panupong, McMahon, Eileen M, Lombari, Theresa R, Bukatina, Anna E, Wu, Qing, Marler, Ronald J, Belohlavek, Marek

“…Abstract Myocardial reperfusion following ischemia may paradoxically cause additional injury, including microvascular damage and edema. These structural…”
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A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium-Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer by Dwyer, Roisin M, Schatz, Stephen M, Bergert, Elizabeth R, Myers, Rae M, Harvey, Mary E, Classic, Kelly L, Blanco, Michael C, Frisk, Craig S, Marler, Ronald J, Davis, Brian J, O'Connor, Michael K, Russell, Stephen J, Morris, John C

“…The sodium-iodide symporter (NIS) is primarily a thyroid protein, providing for the accumulation of iodide for biosynthesis of thyroid hormones. Native NIS…”
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Retraction: Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo by Cabrera, Rosalyn, Schenk, Erin L, Nava-Parada, Pilar, Bell, Michael P, Van Keulen, Virginia P, Marler, Ronald J, Felts, Sara J, Pease, Larry R

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Intravitreal alemtuzumab penetrates full-thickness retina in rabbit eyes by Ekdawi, Noha S, Pulido, Jose S, Itty, Sujit, Marler, Ronald J, Herman, David C, Hardwig, Paul, Mohney, Brian G, Valyi-Nagy, Tibor, Shukla, Deepak

“…The purpose of this study was to assess whether alemtuzamab, a large antibody of 150 kDa, would be able to penetrate through the full-thickness retina of…”
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