Search Results - "Marlar, R A"

Advantages, disadvantages and optimization of one‐stage and chromogenic factor activity assays in haemophilia A and B by Adcock, D. M., Strandberg, K., Shima, M., Marlar, R. A.

“…Haemophilia A and B diagnosis and disease severity classification are determined on the basis of results from factor VIII (FVIII) and factor FIX (FIX) activity…”
Get full text

Laboratory testing issues for protein C, protein S, and antithrombin by Marlar, R. A., Gausman, J. N.

“…Thrombophilia is a complex disease process, which clinically expresses as venous thrombosis. The presence of a genetic defect in one of the major contributing…”
Get full text

The effect of time and temperature variables on routine coagulation tests by Adcock, D, Kressin, D, Marlar, R A

“…This study evaluates the effects of time and temperature variables on routine coagulation assays [Prothrombin Time test and Activated Partial Thromboplastin…”
Get more information

Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing by ADCOCK, D. M, KRESSIN, D. C, MARLAR, R. A

“…The effects of 3.2% and 3.8% sodium citrate concentration on the results of routine coagulation assays (prothrombin time [PT] and activated partial…”
Get full text

Minimum specimen volume requirements for routine coagulation testing Dependence on citrate concentration by ADCOCK, D. M, KRESSIN, D. C, MARLAR, R. A

“…We evaluated the effect of sample volume and citrate concentration on results of routine coagulation assays (prothrombin time [PT] and activated partial…”
Get full text

Coagulation and fibrinolytic profiles in patients with severe pulmonary hypertension by Welsh, C H, Hassell, K L, Badesch, D B, Kressin, D C, Marlar, R A

“…Although in situ thrombosis is a prominent finding in lung vessels from patients with primary and secondary pulmonary hypertension, to our knowledge, plasma…”
Get more information

Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies by Marlar, R A, Neumann, A

“…Homozygous protein C deficiency or homozygous protein S deficiency are rare genetic diseases with catastrophic and fatal purpura fulminans-like or thrombotic…”
Get more information

Accurate testing for dysfunctional molecules: the potential for missing the diagnosis by Marlar, R. A.

Get full text

The effect of instrumentation and laboratory site on the accuracy of the APTT-based heparin therapeutic range by Marlar, R. A., Gausman, J. N.

“…Summary Background Monitoring of unfractionated heparin therapy by activated partial thromboplastin time using the ex vivo method for determining the heparin…”
Get full text

The First Mutation Identified in the Thrombomodulin Gene in a 45-Year-Old Man Presenting With Thromboembolic Disease by Ohlin, Ann-Kristin, Marlar, Richard A.

“…Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-medi-ated activation of protein C (PC). It has been…”
Get full text

Thrombomodulin gene variations and thromboembolic disease by Ohlin, A K, Norlund, L, Marlar, R A

“…Thrombomodulin (TM) is the endothelial cell cofactor for protein C activation. Since deficiencies of other protein C system proteins are known to cause…”
Get more information

High-affinity RNA ligands to human α-thrombin by Kubik, Mark F., Stephens, Andrew W., Schneider, Dan, Marlar, Richard A., Tasset, Diane

“…Systematic Evolution of Ligands by Exponential enrichment (SELEX) was used to isolate from a population of 1013 RNA molecules two classes of high affinity RNAs…”
Get full text

Heparin levels to guide thromboembolism prophylaxis during pregnancy by Barbour, Linda A, Smith, Jeffrey M, Marlar, Richard A

“…OBJECTIVE: Our purpose was to determine the dose of heparin required in pregnant women to achieve the same heparin levels as standard doses of 5000 units given…”
Get full text

Biosynthesis and Secretion of Factor VII, Protein C, Protein S, and the Protein C Inhibitor From a Human Hepatoma Cell Line by Fair, Daryl S., Marlar, Richard A.

“…Using specific radioimmunoassays, 8 day cultures of Hep G2 cells were shown to contain in their supernatants 16, 74, and 828 ng/mL and in their cell lysates,…”
Get full text

Thrombomodulin gene defects in families with thromboembolic disease--a report on four families by Ohlin, A K, Marlar, R A

“…It has been suggested that an impaired thrombomodulin (TM) function could constitute an abnormality leading to thromboembolic disease (TED). The TM gene from…”
Get more information

Neonatal Purpura Fulminans: A Genetic Disorder Related to the Absence of Protein C in Blood by Marciniak, Ewa, Wilson, H. David, Marlar, Richard A.

“…To confirm the pathogenesis and the genetic background of neonatal-onset purpura fulminans, two unrelated infants with this rare thrombotic syndrome and 47 of…”
Get full text

Human Endothelial Cells Synthesize Protein S by Fair, Daryl S., Marlar, Richard A., Levin, Eugene G.

“…Human umbilical vein endothelial cells were analyzed for the presence of prothrombin, factor VII, protein C, and protein S in culture supernatants and cell…”
Get full text

Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men by Hassell, K L, Kressin, D C, Neumann, A, Ellison, R, Marlar, R A

“…Antiphospholipid antibodies (aPL) and free protein S (PSF) deficiency have been associated with clinical thrombosis. Previous reports described a high…”
Get more information

Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease by Marlar, R A, Griffin, J H

“…Activated protein C is an anticoagulant plasma protease enzyme that inactivates Factors V and VIII in plasma. Normal plasma contains a protein that inhibits…”
Get full text

Vitreoretinal findings similar to retinopathy of prematurity in infants with compound heterozygous protein S deficiency by Mintz-Hittner, H A, Miyashiro, M J, Knight-Nanan, D M, O'Malley, R E, Marlar, R A

“…To present previously undescribed vitreoretinal findings similar to severe retinopathy of prematurity (ROP) in two siblings (daughter and son) with a…”
Get more information