Search Results - "Marks, Bryan"

Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis by O'HARE, Thomas, EIDE, Christopher A, RIDDLE, Steven M, MARKS, Bryan D, VOGEI, Kurt W, KOOP, Dennis R, APGAR, John, TYNER, Jeffrey W, DEININGER, Michael W, DRUKER, Brian J, AGARWAL, Anupriya, ADRIAN, Lauren T, ZABRISKIE, Matthew S, MACKENZIE, Ryan J, LATOCHA, Dorian H, JOHNSON, Kara J, HUIHONG YOU, LUO, Jenny

“…The imatinib paradigm in chronic myelogenous leukemia (CML) established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors…”
Get full text

Development and applications of a broad-coverage, TR-FRET-based kinase binding assay platform by Lebakken, Connie S, Riddle, Steven M, Singh, Upinder, Frazee, W Jack, Eliason, Hildegard C, Gao, Yi, Reichling, Laurie J, Marks, Bryan D, Vogel, Kurt W

“…The expansion of kinase assay technologies over the past decade has mirrored the growing interest in kinases as drug targets. As a result, there is no shortage…”
Get more information

Sensing Hydrogen Gas from Atmospheric Pressure to a Hundred Parts per Million with Nanogaps Fabricated Using a Single-Step Bending Deformation by Menumerov, Eredzhep, Marks, Bryan A, Dikin, Dmitriy A, Lee, Francis X, Winslow, Robert D, Guru, Saurav, Sil, Devika, Borguet, Eric, Hutapea, Parsaoran, Hughes, Robert A, Neretina, Svetlana

“…The widespread use of H2 gas as an energy carrier will necessitate the development of inexpensive, easily manufactured sensors which reliably monitor gas…”
Get full text

The Androgen Receptor T877A Mutant Recruits LXXLL and FXXLF Peptides Differently than Wild-Type Androgen Receptor in a Time-Resolved Fluorescence Resonance Energy Transfer Assay by Ozers, Mary Szatkowski, Marks, Bryan D, Gowda, Krishne, Kupcho, Kevin R, Ervin, Kerry M, De Rosier, Therese, Qadir, Naveeda, Eliason, Hildegard C, Riddle, Steven M, Shekhani, Mohammed Saleh

“…The interactions of the ligand binding domain (LBD) of androgen receptor (AR) and the AR T877A mutant, found in prostate cancer, with peptides from coactivator…”
Get full text

A substrate-independent TR-FRET histone deacetylase inhibitor assay by Marks, Bryan D, Fakhoury, Stephen A, Frazee, William J, Eliason, Hildegard C, Riddle, Steven M

“…Developing molecularly targeted therapeutics with minimal off-target effects is facilitated by an understanding of compound selectivity. However, for HDAC…”
Get more information

Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes by Trubetskoy, Olga V, Gibson, Jasmin R, Marks, Bryan D

“…Highly miniaturized P450 screening assays designed to enable facile analysis of P450 drug interactions in a 1536-well plate format with the principal human…”
Get more information

Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening by Shukla, Sunita J, Nguyen, Dac-Trung, Macarthur, Ryan, Simeonov, Anton, Frazee, William J, Hallis, Tina M, Marks, Bryan D, Singh, Upinder, Eliason, Hildegard C, Printen, John, Austin, Christopher P, Inglese, James, Auld, Douglas S

“…The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals, including antibiotics,…”
Get more information

Development of a coactivator displacement assay for the orphan receptor estrogen-related receptor-γ using time-resolved fluorescence resonance energy transfer by Gowda, Krishne, Marks, Bryan D., Zielinski, Thomas K., Ozers, Mary Szatkowski

“…The estrogen-related receptor-γ (ERRγ) is a constitutively active orphan receptor that belongs to the nuclear receptor superfamily and is most closely related…”
Get full text

Development of the predictor HERG fluorescence polarization assay using a membrane protein enrichment approach by Piper, David R, Duff, Steve R, Eliason, Hildegard C, Frazee, W Jack, Frey, Elizabeth A, Fuerstenau-Sharp, Maya, Jachec, Christine, Marks, Bryan D, Pollok, Brian A, Shekhani, Mohammed Saleh, Thompson, David V, Whitney, Pam, Vogel, Kurt W, Hess, Stephen D

“…The life-threatening consequences of acquired, or drug-induced, long QT syndrome due to block of the human ether-a-go-go-related gene (hERG) channel are well…”
Get more information

Multiparameter analysis of a screen for progesterone receptor ligands: comparing fluorescence lifetime and fluorescence polarization measurements by Marks, Bryan D, Qadir, Naveeda, Eliason, Hildegard C, Shekhani, Mohammed Saleh, Doering, Klaus, Vogel, Kurt W

“…Direct measurement of the fluorescence lifetime (FLT) of a fluorescent label is an emerging method for high-throughput screening. Changes in the fluorescence…”
Get more information

High-throughput screening assays for the assessment of CYP2C91, CYP2C92, and CYP2C93 metabolism using fluorogenic Vivid substrates by Marks, Bryan D, Thompson, David V, Goossens, Tony A, Trubetskoy, Olga V

“…CYP2C9 is a genetically polymorphic human cytochrome P450 isozyme involved in the oxidative metabolism of many drugs, including nonsteroidal anti-inflammatory…”
Get more information

A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate by Marks, Bryan D, Smith, Ronald W, Braun, Heidi A, Goossens, Tony A, Christenson, Marie, Ozers, Mary S, Lebakken, Connie S, Trubetskoy, Olga V

“…Large-scale screening of multiple compound libraries and combinatorial libraries for pharmacological activity is one of the novel approaches of the modern drug…”
Get more information

High-Throughput screeening assays for CYP2B6 metabolism and inhibition usuing fluorogenic vivid substrates by Marks, Bryan D., Goossens, Tony A., Braun, Heidi A., Ozers, Mary S., Smith, Ronald W., Lebakken, Connie, Trubetskoy, Olga V.

“…CYP2B6 is a highly polymorphic P450 isozyme involved in the metabolism of endo-and xenobiotics with known implications for the activation of many…”
Get full text

Validation of LC–MS/MS methods for quantitative analysis of kynurenine pathway metabolites in human plasma and cerebrospinal fluid by Khetarpal, Vinod, Herbst, Todd, Akhtar, Shahzad, LaFayette, Amber, Miller, Dennis, Farnham, James, Steege, Troy, Miao, Zhixin, Marks, Bryan, Ledvina, Aaron, Dominguez, Celia

“…Dysregulation of the kynurenine metabolic pathway has been reported in several neurological conditions. Sensitive and selective LC–MS/MS methods have been…”
Get full text

Abstract 5496: Determination of drug-kinase residence time in a homogenous, low-volume format by Marks, Bryan, Lebakken, Connie, Riddle, Steve, Somberg, Richard, Hereley, Sara

“…In addition to drug-target affinity, drug-target residence time is becoming recognized as a critical parameter influencing drug efficacy. Desired compound…”
Get full text

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells define commitment to apoptosis by O’Hare, Thomas, Eide, Christopher A., Agarwal, Anupriya, Adrian, Lauren T., Zabriskie, Matthew S., MacKenzie, Ryan J., LaTocha, Dorian H., Johnson, Kara J., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan D., Vogel, Kurt W., Koop, Dennis R., Apgar, John, Tyner, Jeffrey W., Deininger, Michael W., Druker, Brian J.

“…The imatinib paradigm in chronic myeloid leukemia (CML) established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors…”
Get full text

Cryptic Intracellular Retention of ABL Tyrosine Kinase Inhibitors within CML Cells Mediates Apoptosis Commitment Following Acute Drug Exposure by O'Hare, Thomas, Eide, Christopher A., Adrian, Lauren T., Agarwal, Anupriya, Zabriskie, Matthew S., MacKenzie, Ryan, LaTocha, Dorian H., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan, Koop, Dennis R., Apgar, John, Deininger, Michael W., Druker, Brian J.

“…Abstract 3504 The imatinib paradigm established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors (TKIs). However,…”
Get full text

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line by Trubetskoy, Olga, Marks, Bryan, Zielinski, Thomas, Yueh, Mei-Fei, Raucy, Judy

“…The DPX-2 cell line, a derivative of HepG2 cells, harbors human PXR and a luciferase-linked CYP3A4 promoter. These cells were used in a panel of cell-based…”
Get full text

High-throughput screening assays for CYP2B6 metabolism and inhibition using fluorogenic vivid substrates by Marks, Bryan D, Goossens, Tony A, Braun, Heidi A, Ozers, Mary S, Smith, Ronald W, Lebakken, Connie, Trubetskoy, Olga V

“…CYP2B6 is a highly polymorphic P450 isozyme involved in the metabolism of endo- and xenobiotics with known implications for the activation of many…”
Get full text