Search Results - "Markowski, Todd W."

Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells by Jing, Yawu, Ni, Zhenya, Wu, Jianming, Higgins, LeeAnn, Markowski, Todd W, Kaufman, Dan S, Walcheck, Bruce

“…CD16a and CD16b are IgG Fc receptors expressed by human natural killer (NK) cells and neutrophils, respectively. Both CD16 isoforms undergo a rapid…”
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Non-ATG-initiated translation directed by microsatellite expansions by Zu, Tao, Gibbens, Brian, Doty, Noelle S, Gomes-Pereira, Mário, Huguet, Aline, Stone, Matthew D, Margolis, Jamie, Peterson, Mark, Markowski, Todd W, Ingram, Melissa A.C, Nan, Zhenhong, Forster, Colleen, Low, Walter C, Schoser, Benedikt, Somia, Nikunj V, Clark, H. Brent, Schmechel, Stephen, Bitterman, Peter B, Gourdon, Geneviève, Swanson, Maurice S, Moseley, Melinda, Ranum, Laura P.W

“…Trinucleotide expansions cause disease by both protein- and RNA-mediated mechanisms. Unexpectedly, we discovered that CAG expansion constructs express…”
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Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis by Khan, Salmaan Ahmed, Wollaston-Hayden, Edith E., Markowski, Todd W., Higgins, LeeAnn, Mashek, Douglas G.

“…Hepatic steatosis is characterized by the accumulation of lipid droplets (LDs), which are composed of a neutral lipid core surrounded by a phospholipid…”
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Organelle interactions compartmentalize hepatic fatty acid trafficking and metabolism by Najt, Charles P., Adhikari, Santosh, Heden, Timothy D., Cui, Wenqi, Gansemer, Erica R., Rauckhorst, Adam J., Markowski, Todd W., Higgins, LeeAnn, Kerr, Evan W., Boyum, Matthew D., Alvarez, Jonas, Brunko, Sophia, Mehra, Dushyant, Puchner, Elias M., Taylor, Eric B., Mashek, Douglas G.

“…Organelle interactions play a significant role in compartmentalizing metabolism and signaling. Lipid droplets (LDs) interact with numerous organelles,…”
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Glycoprotein nonmetastatic melanoma protein B (GNMPB) as a novel biomarker for cerebral adrenoleukodystrophy by Taghizadeh, Leyla A., King, Carina J., Nascene, David R., Gupta, Ashish O., Orchard, Paul J., Higgins, LeeAnn, Markowski, Todd W., Nolan, Erin E., Furcich, Justin W., Lund, Troy C.

“…Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disease caused by a mutation in the ABCD1 gene, producing mutations in the very long chain fatty acid…”
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Proteomic profiling of a robust Wolbachia infection in an Aedes albopictus mosquito cell line by Baldridge, Gerald D., Baldridge, Abigail S., Witthuhn, Bruce A., Higgins, LeeAnn, Markowski, Todd W., Fallon, Ann M.

“…Summary Wolbachia pipientis, a widespread vertically transmitted intracellular bacterium, provides a tool for insect control through manipulation of…”
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An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum by Oliva Chávez, Adela S, Fairman, James W, Felsheim, Roderick F, Nelson, Curtis M, Herron, Michael J, Higgins, LeeAnn, Burkhardt, Nicole Y, Oliver, Jonathan D, Markowski, Todd W, Kurtti, Timothy J, Edwards, Thomas E, Munderloh, Ulrike G

“…Anaplasma phagocytophilum, the causative agent of Human Granulocytic Anaplasmosis (HGA), is an obligately intracellular α-proteobacterium that is transmitted…”
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Tandem mass tag proteomic and untargeted metabolomic profiling reveals altered serum and CSF biochemical datasets in iron deficient monkeys by Sandri, Brian J, Kim, Jonathan, Lubach, Gabriele R., Lock, Eric F, Guerrero, Candace, Higgins, LeeAnn, Markowski, Todd W, Kling, Pamela J, Georgieff, Michael K, Coe, Christopher L., Rao, Raghavendra B

“…The effects of early-life iron deficiency anemia (IDA) extend past the blood and include both short- and long-term adverse effects on many tissues including…”
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Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis by Andersen, John D., Boylan, Kristin L. M., Xue, Feifei S., Anderson, Lorraine B., Witthuhn, Bruce A., Markowski, Todd W., Higgins, LeeAnn, Skubitz, Amy P. N.

“…Ovarian cancer is the fifth leading cause of cancer death for women in the US, yet survival rates are over 90% when it is diagnosed at an early stage,…”
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Mosaic composition of ribA and wspB genes flanking the virB8-D4 operon in the Wolbachia supergroup B-strain, wStr by Baldridge, Gerald D, Li, Yang Grace, Witthuhn, Bruce A, Higgins, LeeAnn, Markowski, Todd W, Baldridge, Abigail S, Fallon, Ann M

“…The obligate intracellular bacterium, Wolbachia pipientis (Rickettsiales), is a widespread, vertically transmitted endosymbiont of filarial nematodes and…”
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Identification by mass spectrometry and immune response analysis of guinea pig cytomegalovirus (GPCMV) pentameric complex proteins GP129, 131 and 133 by Gnanandarajah, Josephine S, Gillis, Peter A, Hernandez-Alvarado, Nelmary, Higgins, LeeAnn, Markowski, Todd W, Sung, Heungsup, Lumley, Sheila, Schleiss, Mark R

“…Development of a vaccine against congenital infection with human cytomegalovirus (HCMV) is a major public health priority. A potential vaccine target receiving…”
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Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice by Goldblum, Rebecca R., McClellan, Mark, White, Kyle, Gonzalez, Samuel J., Thompson, Brian R., Vang, Hluechy X., Cohen, Houda, Higgins, LeeAnn, Markowski, Todd W., Yang, Tzu-Yi, Metzger, Joseph M., Gardner, Melissa K.

“…In the failing heart, the cardiac myocyte microtubule network is remodeled, which contributes to cellular contractile failure and patient death. However, the…”
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Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation by Elton, Andrew C., Cedarstrom, Vannesa, Quraishi, Arman, Wuertz, Beverly, Murray, Kevin, Markowski, Todd W., Seabloom, Donna, Ondrey, Frank G.

“…Epidemiologic studies of diabetic patients treated with metformin identified significantly lower incidences of cancer. From this, there is growing interest in…”
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Global phosphoproteomic profiling of skeletal muscle in ovarian hormone-deficient mice by Peyton, Mina P, Yang, Tzu-Yi, Higgins, LeeAnn, Markowski, Todd W, Vue, Cha, Parker, Laurie L, Lowe, Dawn A

“…Protein phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscle…”
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Multiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia by Sandri, Brian J, Kim, Jonathan, Lubach, Gabriele R, Lock, Eric F, Guerrero, Candace, Higgins, LeeAnn, Markowski, Todd W, Kling, Pamela J, Georgieff, Michael K, Coe, Christopher L, Rao, Raghavendra B

“…The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues…”
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Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells by Chen, Dongmei, Wirth, Keith M, Kizy, Scott, Muretta, Joseph M, Markowski, Todd W, Yong, Peter, Sheka, Adam, Abdelwahab, Hisham, Hertzel, Ann V, Ikramuddin, Sayeed, Yamamoto, Masato, Bernlohr, David A

“…Fatty acid binding protein 4 (FABP4) is a secreted adipokine linked to obesity and progression of a variety of cancers. Obesity increases extracellular FABP4…”
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Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice by Peyton, Mina P, Yang, Tzu-Yi, Higgins, LeeAnn, Markowski, Todd W, Murray, Kevin, Vue, Cha, Parker, Laurie L, Lowe, Dawn A

“…The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, we questioned how estrogen deficiency might impact…”
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A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals by Liu, Peng, Smith, Benjamin R., Montonye, Michelle L., Kemper, Lisa J., Leinonen-Wright, Kailee, Nelson, Kathryn M., Higgins, LeeAnn, Guerrero, Candace R., Markowski, Todd W., Zhao, Xiaohui, Petersen, Ashley J., Knopman, David S., Petersen, Ronald C., Ashe, Karen H.

“…Neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease, and their levels correlate with the severity of cognitive dysfunction in humans…”
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Cerebral adrenoleukodystrophy is associated with loss of tolerance to profilin by Orchard, Paul J., Nascene, David R., Gupta, Ashish, Taisto, Mandy E., Higgins, LeeAnn, Markowski, Todd W., Lund, Troy C.

“…Childhood cerebral adrenoleukodystrophy (cALD) is a devastating manifestation of ALD accompanied by demyelination, inflammation, and blood brain barrier (BBB)…”
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Characterizing the Epothilone Binding Site on β‑Tubulin by Photoaffinity Labeling: Identification of β‑Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin by Ranade, Adwait R, Higgins, LeeAnn, Markowski, Todd W, Glaser, Nicole, Kashin, Dmitry, Bai, Ruoli, Hong, Kwon Ho, Hamel, Ernest, Höfle, Gerhard, Georg, Gunda I

“…Photoaffinity labeling with an epothilone A photoprobe led to the identification of the β-tubulin peptides TARGSQQY and TSRGSQQY as targets of the photoprobe…”
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