Incidence of epilepsy in a racially diverse, community-dwelling, elderly cohort: Results from the Einstein aging study

To determine age-specific incidence and cumulative incidence of epilepsy in a well-defined cohort of elderly people, and to examine how rates of epilepsy are modified by sex, race, stroke, dementia, head injury, and depression. The authors examined data from a reconstructed cohort based on 1919 comm...

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Bibliographic Details
Published in:	Epilepsy research Vol. 71; no. 2; pp. 195 - 205
Main Authors:	Hussain, S.A., Haut, S.R., Lipton, R.B., Derby, C., Markowitz, S.Y., Shinnar, S.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-10-2006 Elsevier
Subjects:	African Americans African-American Age Distribution Aged Aged, 80 and over Aging - physiology Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Comorbidity Craniocerebral Trauma - complications Craniocerebral Trauma - epidemiology Cumulative risk Dementia - complications Dementia - epidemiology Elderly Epilepsy Epilepsy - epidemiology Epilepsy - ethnology Epilepsy - etiology European Continental Ancestry Group Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Incidence Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Prospective Studies Race Risk Factors Stroke - complications Stroke - epidemiology African-American Elderly Epilepsy Cumulative risk Race Incidence Senescence American Craniocerebral Sex Cardiovascular disease Vascular disease Prospective Age of onset Cerebrovascular disease Human Mood disorder Nervous system diseases Stroke Depression Cerebral disorder African Treatment Central nervous system disease Risk factor Surgical approach Head trauma Comparative study Dementia
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Summary:	To determine age-specific incidence and cumulative incidence of epilepsy in a well-defined cohort of elderly people, and to examine how rates of epilepsy are modified by sex, race, stroke, dementia, head injury, and depression. The authors examined data from a reconstructed cohort based on 1919 community-dwelling volunteers, followed as part of a large ongoing prospective aging study. Age-specific incidence was 10.6 (per 100,000 person-years) between ages 45 and 59, 25.8 between ages 60 and 74, and 101.1 between ages 75 and 89. Cumulative incidence was 0.15% from age 45 to age 60, 0.38% to age 70, 1.01% to age 80, and 1.47% to age 90. In addition, the difference in cumulative incidence among African-American subjects approached statistical significance (57.6/100,000 person-years versus 26.1 in Caucasian, p = 0.10), and the difference in incidence among subjects reporting a history of stroke was significantly elevated ( p = 0.029). Incidence of epilepsy was not statistically elevated among males, those with dementia, or individuals reporting a history of head injury or treatment for depression. Among “healthy” subjects without history of stroke, head injury, or dementia, we observed a cumulative risk of epilepsy with onset after age 60 of only 1.1%. The incidence of epilepsy was low in this relatively healthy cohort of elderly people, especially among subjects without known risk factors. In this study we identified African-American race as a risk factor in the elderly for epilepsy independent of stroke.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2006.06.018