Search Results - "Markovitz, M."

A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo by Covés-Datson, Evelyn M., King, Steven R., Legendre, Maureen, Gupta, Auroni, Chan, Susana M., Gitlin, Emily, Kulkarni, Vikram V., García, Jezreel Pantaleón, Smee, Donald F., Lipka, Elke, Evans, Scott E., Tarbet, E. Bart, Ono, Akira, Markovitz, David M.

“…There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination and existing treatments are only moderately effective. We previously…”
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H84T BanLec has broad spectrum antiviral activity against human herpesviruses in cells, skin, and mice by Lloyd, M. G., Liu, D., Legendre, M., Markovitz, D. M., Moffat, J. F.

“…H84T BanLec is a molecularly engineered lectin cloned from bananas with broad-spectrum antiviral activity against several RNA viruses. H84T BanLec dimers bind…”
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A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication by Swanson, Michael D., Winter, Harry C., Goldstein, Irwin J., Markovitz, David M.

“…BanLec is a jacalin-related lectin isolated from the fruit of bananas, Musa acuminata. This lectin binds to high mannose carbohydrate structures, including…”
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Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice by Helm, Johannes, Mereiter, Stefan, Oliveira, Tiago, Gattinger, Anna, Markovitz, David M., Penninger, Josef M., Altmann, Friedrich, Stadlmann, Johannes

“…N-glycosylation is one of the most common protein modifications in eukaryotes, with immense importance at the molecular, cellular, and organismal level…”
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Targeting glycans for CAR therapy: The advent of sweet CARs by Raglow, Zoe, McKenna, Mary Kathryn, Bonifant, Challice L., Wang, Wenjing, Pasca di Magliano, Marina, Stadlmann, Johannes, Penninger, Josef M., Cummings, Richard D., Brenner, Malcolm K., Markovitz, David M.

“…Chimeric antigen receptor (CAR) T cell therapy has created a paradigm shift in the treatment of hematologic malignancies but has not been as effective toward…”
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Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble by Stelzer, Andrew C, Frank, Aaron T, Kratz, Jeremy D, Swanson, Michael D, Gonzalez-Hernandez, Marta J, Lee, Janghyun, Andricioaei, Ioan, Markovitz, David M, Al-Hashimi, Hashim M

“…Protein-focused lead-identification strategies may be limited in their ability to identify small molecules that bind to cellular RNAs. Docking small molecules…”
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The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells by Chan, Susana M, Sapir, Tamar, Park, Sung-Soo, Rual, Jean-François, Contreras-Galindo, Rafael, Reiner, Orly, Markovitz, David M

“…Human endogenous retroviruses are remnants of ancient germline infections that make up approximately 8% of the modern human genome. The HERV-K (HML-2) family…”
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Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin by Covés-Datson, Evelyn M, Dyall, Julie, DeWald, Lisa Evans, King, Steven R, Dube, Derek, Legendre, Maureen, Nelson, Elizabeth, Drews, Kelly C, Gross, Robin, Gerhardt, Dawn M, Torzewski, Lisa, Postnikova, Elena, Liang, Janie Y, Ban, Bhupal, Shetty, Jagathpala, Hensley, Lisa E, Jahrling, Peter B, Olinger, Jr, Gene G, White, Judith M, Markovitz, David M

“…Ebolaviruses cause an often rapidly fatal syndrome known as Ebola virus disease (EVD), with average case fatality rates of ~50%. There is no licensed vaccine…”
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DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis by Mor-Vaknin, Nirit, Saha, Anjan, Legendre, Maureen, Carmona-Rivera, Carmelo, Amin, M Asif, Rabquer, Bradley J., Gonzales-Hernandez, Marta J., Jorns, Julie, Mohan, Smriti, Yalavarthi, Srilakshmi, Pai, Dave A., Angevine, Kristine, Almburg, Shelley J., Knight, Jason S., Adams, Barbara S., Koch, Alisa E., Fox, David A., Engelke, David R., Kaplan, Mariana J., Markovitz, David M.

“…Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers are single-stranded RNA or DNA molecules that have…”
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Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis by Paul, Souren, Kaplan, Mark H., Khanna, Dinesh, McCourt, Preston M., Saha, Anjan K., Tsou, Pei-Suen, Anand, Mahek, Radecki, Alexander, Mourad, Mohamad, Sawalha, Amr H., Markovitz, David M., Contreras-Galindo, Rafael

“…Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite the fact that many centromere proteins were discovered in patients with SSc…”
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Vimentin is secreted by activated macrophages by Markovitz, David M, Mor-Vaknin, Nirit, Punturieri, Antonello, Sitwala, Kajal

“…Vimentin is a widely expressed intermediate filament protein thought to be involved mainly in structural processes, such as wound healing. We now demonstrate…”
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Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection by Christodoulou, Ilias, Rahnama, Ruyan, Ravich, Jonas W, Seo, Jaesung, Zolov, Sergey N, Marple, Andrew N, Markovitz, David M, Bonifant, Challice L

“…H84T-Banana Lectin (BanLec) CAR-NK cells bind high mannose glycosites that decorate the SARS-CoV-2 envelope, thereby decreasing cellular infection in a model…”
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Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils by Huynh, Thao Ngoc, Toperzer, Jody, Scherer, Allison, Gumina, Anne, Brunetti, Tonya, Mansour, Michael K, Markovitz, David M, Russo, Brian C

“…The intermediate filament vimentin is present in immune cells and is implicated in proinflammatory immune responses. Whether and how it supports antimicrobial…”
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The Genomic Landscape of Centromeres in Cancers by Saha, Anjan K., Mourad, Mohamad, Kaplan, Mark H., Chefetz, Ilana, Malek, Sami N., Buckanovich, Ronald, Markovitz, David M., Contreras-Galindo, Rafael

“…Centromere genomics remain poorly characterized in cancer, due to technologic limitations in sequencing and bioinformatics methodologies that make…”
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Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1 by GONZALEZ-HERNANDEZ, Marta J, SWANSON, Michael D, CONTRERAS-GALINDO, Rafael, COOKINHAM, Sarah, KING, Steven R, NOEL, Richard J, KAPLAN, Mark H, MARKOVITZ, David M

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Vimentin, a Novel NF-κB Regulator, Is Required for Meningitic Escherichia coli K1-Induced Pathogen Invasion and PMN Transmigration across the Blood-Brain Barrier by Huang, Sheng-He, Chi, Feng, Peng, Liang, Bo, Tao, Zhang, Bao, Liu, Li-Qun, Wu, Xuedong, Mor-Vaknin, Nirit, Markovitz, David M, Cao, Hong, Zhou, Yan-Hong

“…NF-κB activation, pathogen invasion, polymorphonuclear leukocytes (PMN) transmigration (PMNT) across the blood-brain barrier (BBB) are the pathogenic triad…”
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HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses by Contreras-Galindo, Rafael, Kaplan, Mark H, He, Shirley, Contreras-Galindo, Angie C, Gonzalez-Hernandez, Marta J, Kappes, Ferdinand, Dube, Derek, Chan, Susana M, Robinson, Dan, Meng, Fan, Dai, Manhong, Gitlin, Scott D, Chinnaiyan, Arul M, Omenn, Gilbert S, Markovitz, David M

“…Human endogenous retroviruses (HERVs) make up 8% of the human genome. The HERV-K (HML-2) family is the most recent group of these viruses to have inserted into…”
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Human Endogenous Retrovirus K Gag Coassembles with HIV-1 Gag and Reduces the Release Efficiency and Infectivity of HIV-1 by Monde, Kazuaki, Contreras-Galindo, Rafael, Kaplan, Mark H., Markovitz, David M., Ono, Akira

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The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival by Hacker, Kari E, Bolland, Danielle E, Tan, Lijun, Saha, Anjan K, Niknafs, Yashar S, Markovitz, David M, McLean, Karen

“…DNA damage repair alterations play a critical role in ovarian cancer tumorigenesis. Mechanistic drivers of the DNA damage response consequently present…”
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Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer by CONTRERAS-GALINDO, Rafael, KAPLAN, Mark H, MARKOVITZ, David M, LEISSNER, Philippe, VERJAT, Thibault, FERLENGHI, Ilaria, BAGNOLI, Fabio, GIUSTI, Fabiola, DOSIK, Michael H, HAYES, Daniel F, GITLIN, Scott D

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