Search Results - "Markovetz, Matthew"

Mucus, mucins, and cystic fibrosis by Morrison, Cameron Bradley, Markovetz, Matthew Raymond, Ehre, Camille

“…Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the Caucasian population. CF is caused by mutations in the cystic fibrosis…”
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Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice by Hancock, Laura A., Hennessy, Corinne E., Solomon, George M., Dobrinskikh, Evgenia, Estrella, Alani, Hara, Naoko, Hill, David B., Kissner, William J., Markovetz, Matthew R., Grove Villalon, Diane E., Voss, Matthew E., Tearney, Guillermo J., Carroll, Kate S., Shi, Yunlong, Schwarz, Marvin I., Thelin, William R., Rowe, Steven M., Yang, Ivana V., Evans, Christopher M., Schwartz, David A.

“…The gain-of-function MUC5B promoter variant rs35705950 is the dominant risk factor for developing idiopathic pulmonary fibrosis (IPF). Here we show in humans…”
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Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH by Hill, David B, Long, Robert F, Kissner, William J, Atieh, Eyad, Garbarine, Ian C, Markovetz, Matthew R, Fontana, Nicholas C, Christy, Matthew, Habibpour, Mehdi, Tarran, Robert, Forest, M Gregory, Boucher, Richard C, Button, Brian

“…Cystic fibrosis (CF) is a recessive genetic disease that is characterised by airway mucus plugging and reduced mucus clearance. There are currently alternative…”
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An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases by Ehre, Camille, Rushton, Zachary L, Wang, Boya, Hothem, Lauren N, Morrison, Cameron B, Fontana, Nicholas C, Markovetz, Matthew R, Delion, Martial F, Kato, Takafumi, Villalon, Diane, Thelin, William R, Esther, Jr, Charles R, Hill, David B, Grubb, Barbara R, Livraghi-Butrico, Alessandra, Donaldson, Scott H, Boucher, Richard C

“…Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature of muco-obstructive respiratory diseases, including chronic…”
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Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis by Esther, Jr, Charles R, Muhlebach, Marianne S, Ehre, Camille, Hill, David B, Wolfgang, Matthew C, Kesimer, Mehmet, Ramsey, Kathryn A, Markovetz, Matthew R, Garbarine, Ian C, Forest, M Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B, Delion, Martial F, Thelin, William R, Villalon, Diane, Sabater, Juan R, Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M, Boucher, Richard C

“…Although destructive airway disease is evident in young children with cystic fibrosis (CF), little is known about the nature of the early CF lung environment…”
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Combination treatment to improve mucociliary transport of Pseudomonas aeruginosa biofilms by Rouillard, Kaitlyn R, Esther, Christopher P, Kissner, William J, Plott, Lucas M, Bowman, Dean W, Markovetz, Matthew R, Hill, David B

“…People with muco-obstructive pulmonary diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) often have acute or chronic…”
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Induction of ciliary orientation by matrix patterning and characterization of mucociliary transport by Sears, Patrick R., Bustamante-Marin, Ximena M., Gong, Henry, Markovetz, Matthew R., Superfine, Richard, Hill, David B., Ostrowski, Lawrence E.

“…Impaired mucociliary clearance (MCC) is a key feature of many airway diseases, including asthma, bronchiectasis, chronic obstructive pulmonary disease, cystic…”
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Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration by Morrison, Cameron B, Shaffer, Kendall M, Araba, Kenza C, Markovetz, Matthew R, Wykoff, Jason A, Quinney, Nancy L, Hao, Shuyu, Delion, Martial F, Flen, Alexis L, Morton, Lisa C, Liao, Jimmy, Hill, David B, Drumm, Mitchell L, O'Neal, Wanda K, Kesimer, Mehmet, Gentzsch, Martina, Ehre, Camille

“…Cystic fibrosis (CF) is characterised by the accumulation of viscous adherent mucus in the lungs. While several hypotheses invoke a direct relationship with…”
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Effects of Mucin and DNA Concentrations in Airway Mucus on Pseudomonas aeruginosa Biofilm Recalcitrance by Rouillard, Kaitlyn R., Kissner, William J., Markovetz, Matthew R., Hill, David B.

“…The pathological properties of airway mucus in cystic fibrosis (CF) are dictated by mucus concentration and composition, with mucins and DNA being responsible…”
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Endotracheal tube mucus as a source of airway mucus for rheological study by Markovetz, Matthew R, Subramani, Durai B, Kissner, William J, Morrison, Cameron B, Garbarine, Ian C, Ghio, Andrew, Ramsey, Kathryn A, Arora, Harendra, Kumar, Priya, Nix, David B, Kumagai, Tadahiro, Krunkosky, Thomas M, Krause, Duncan C, Radicioni, Giorgia, Alexis, Neil E, Kesimer, Mehmet, Tiemeyer, Michael, Boucher, Richard C, Ehre, Camille, Hill, David B

“…Muco-obstructive lung diseases (MOLDs), like cystic fibrosis and chronic obstructive pulmonary disease, affect a spectrum of subjects globally. In MOLDs, the…”
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Mucus polymer concentration and in vivo adaptation converge to define the antibiotic response of Pseudomonas aeruginosa during chronic lung infection by Greenwald, Matthew A, Meinig, Suzanne L, Plott, Lucas M, Roca, Cristian, Higgs, Matthew G, Vitko, Nicholas P, Markovetz, Matthew R, Rouillard, Kaitlyn R, Carpenter, Jerome, Kesimer, Mehmet, Hill, David B, Schisler, Jonathan C, Wolfgang, Matthew C

“…The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of…”
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BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance by Donoghue, Lauren J, Markovetz, Matthew R, Morrison, Cameron B, Chen, Gang, McFadden, Kathryn M, Sadritabrizi, Taraneh, Gutay, Mark I, Kato, Takafumi, Rogers, Troy D, Snead, Jazmin Y, Livraghi-Butrico, Alessandra, Button, Brian, Ehre, Camille, Grubb, Barbara R, Hill, David B, Kelada, Samir N P

“…Airway mucociliary clearance (MCC) is required for host defense and is often diminished in chronic lung diseases. Effective clearance depends upon coordinated…”
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Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis by Dougherty, Gerard W, Ostrowski, Lawrence E, Nöthe-Menchen, Tabea, Raidt, Johanna, Schramm, Andre, Olbrich, Heike, Yin, Weining, Sears, Patrick R, Dang, Hong, Smith, Amanda J, Beule, Achim G, Hjeij, Rim, Rutjes, Niels, Haarman, Eric G, Maas, Saskia M, Ferkol, Thomas W, Noone, Peadar G, Olivier, Kenneth N, Bracht, Diana C, Barbry, Pascal, Zaragosi, Laure-Emmanuelle, Fierville, Morgane, Kliesch, Sabine, Wohlgemuth, Kai, König, Julia, George, Sebastian, Loges, Niki T, Ceppe, Agathe, Markovetz, Matthew R, Luo, Hong, Guo, Ting, Rizk, Hoda, Eldesoky, Tarek, Dahlke, Katrin, Boldt, Karsten, Ueffing, Marius, Hill, David B, Pang, Yuan-Ping, Knowles, Michael R, Zariwala, Maimoona A, Omran, Heymut

“…Bronchiectasis is a pathological dilatation of the bronchi in the respiratory airways associated with environmental or genetic causes (e.g., cystic fibrosis,…”
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Normalizing salt content by mixing native human airway mucus samples normalizes sample rheology by Markovetz, Matthew R, Hibbard, Jacob E, Plott, Lucas M, Bacudio, Lawrence G, Kissner, William J, Ghio, Andrew, Kumar, Priya A, Arora, Harendra, Hill, David B

“…Across the globe, millions of people are affected by muco-obstructive pulmonary diseases like cystic fibrosis, asthma, and chronic obstructive pulmonary…”
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Altering the viscoelastic properties of mucus-grown Pseudomonas aeruginosa biofilms affects antibiotic susceptibility by Rouillard, Kaitlyn R., Markovetz, Matthew R., Kissner, William J., Boone, William L., Plott, Lucas M., Hill, David B.

“…The viscoelastic properties of biofilms are correlated with their susceptibility to mechanical and chemical stress, and the airway environment in…”
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Mucus and mucus flake composition and abundance reflect inflammatory and infection status in cystic fibrosis by Markovetz, Matthew R., Garbarine, Ian C., Morrison, Cameron B., Kissner, William J., Seim, Ian, Forest, M. Gregory, Papanikolas, Micah J., Freeman, Ronit, Ceppe, Agathe, Ghio, Andrew, Alexis, Neil E., Stick, Stephen M., Ehre, Camille, Boucher, Richard C., Esther, Charles R., Muhlebach, Marianne S., Hill, David B.

“…•Mucus flakes in CF BALF were larger and more abundant than flakes in normal BALF.•Mucin and DNA content were also elevated in CF BALF.•Insoluble CF flakes…”
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Pseudomonas aeruginosa Biofilm Eradication via Nitric Oxide-Releasing Cyclodextrins by Rouillard, Kaitlyn R, Markovetz, Matthew R, Bacudio, Lawrence G, Hill, David B, Schoenfisch, Mark H

“…Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients. Chronic respiratory infections are rarely…”
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Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer by Wykoff, Jason A, Shaffer, Kendall M, Araba, Kenza C, Markovetz, Matthew R, Patarin, Jérémy, Robert de Saint Vincent, Matthieu, Donaldson, Scott H, Ehre, Camille

“…In muco-obstructive lung diseases (e.g., asthma, chronic obstructive pulmonary disease, cystic fibrosis) and other respiratory conditions (e.g.,…”
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Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung by Locke, Landon W, Myerburg, Michael M, Weiner, Daniel J, Markovetz, Matthew R, Parker, Robert S, Muthukrishnan, Ashok, Weber, Lawrence, Czachowski, Michael R, Lacy, Ryan T, Pilewski, Joseph M, Corcoran, Timothy E

“…Airway surface liquid hyperabsorption and mucus accumulation are key elements of cystic fibrosis lung disease that can be assessed in vivo using functional…”
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Molecular dynamics simulations to explore the structure and rheological properties of normal and hyperconcentrated airway mucus by Ford, Andrew G., Cao, Xue‐Zheng, Papanikolas, Micah J., Kato, Takafumi, Boucher, Richard C., Markovetz, Matthew R., Hill, David B., Freeman, Ronit, Forest, Mark Gregory

“…We develop the first molecular dynamics model of airway mucus based on the detailed physical properties and chemical structure of the predominant gel‐forming…”
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