Search Results - "Marko, Daniel M."

Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes by Rodrigues E-Lacerda, Rodrigo, Fang, Han, Robin, Nazli, Bhatwa, Arshpreet, Marko, Daniel M, Schertzer, Jonathan D

“…Gut microbiota influence host immunity and metabolism during obesity. Bacterial sensors of the innate immune system relay signals from specific bacterial…”
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Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling by Baranowski, Bradley J, Hayward, Grant C, Marko, Daniel M, MacPherson, Rebecca E K

“…Perturbations in metabolism results in the accumulation of beta-amyloid peptides, which is a pathological feature of Alzheimer's disease. Beta-site amyloid…”
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Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells by Marko, Daniel M, Foran, Gregory, Vlavcheski, Filip, Baron, David C, Hayward, Grant C, Baranowski, Bradley J, Necakov, Aleksander, Tsiani, Evangelia, MacPherson, Rebecca E K

“…Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 can…”
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Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice by Cleverdon, Riley E.G., Braun, Jessica L., Geromella, Mia S., Whitley, Kennedy C., Marko, Daniel M., Hamstra, Sophie I., Roy, Brian D., MacPherson, Rebecca E.K., Fajardo, Val A.

“…The DBA/2J (D2) mdx mouse is a more severe model of Duchenne muscular dystrophy when compared to the traditional C57BL/10 (C57) mdx mouse. Here, we questioned…”
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Intermittent fasting influences immunity and metabolism by Marko, Daniel M., Conn, Meghan O., Schertzer, Jonathan D.

“…Obesity compromises metabolic flexibility and increases specific immune responses.Fasting forces metabolic flexibility and alters glucose, fatty acids,…”
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Intermittent fasting increases fat oxidation and promotes metabolic flexibility in lean mice but not obese type 2 diabetic mice by Conn, Meghan O, Marko, Daniel M, Schertzer, Jonathan D

“…Obesity and type 2 diabetes (T2D) are associated with metabolic inflexibility, characterized by an impaired ability to switch between substrate storage and…”
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Amyloid beta 42 oligomers induce neuronal and synaptic receptor dysfunctions by Finch, Michael S., Bagit, Ahmed, Marko, Daniel M.

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Rac1 supports muscle glucose uptake independently of Akt by Marko, Daniel M., Shamshoum, Hesham

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Kinase inhibitors for cancer alter metabolism, blood glucose, and insulin by Duggan, Brittany M, Marko, Daniel M, Muzaffar, Raveen, Chan, Darryl Y, Schertzer, Jonathan D

“…Small molecule kinase inhibitors (SMKIs) are a class of therapeutic drugs that target protein kinases in diseases such as cancer. SMKIs are often designed to…”
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Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition by Baranowski, Bradley J, Mohammad, Ahmad, Finch, Michael S, Brown, Alex, Dhaliwal, Roopan, Marko, Daniel M, LeBlanc, Paul J, McCormick, Cheryl M, Fajardo, Val A, MacPherson, Rebecca E K

“…Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk. Acute exercise reduces the activity of β-site amyloid precursor…”
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Postexercise serum from humans influences the biological tug of war of APP processing in human neuronal cells by Marko, Daniel M, Finch, Michael S, Mohammad, Ahmad, MacNeil, Adam J, Klentrou, Panagiota, MacPherson, Rebecca E K

“…Neurodegenerative diseases such as Alzheimer's disease (AD) are becoming more prevalent in our aging society. One specific neuropathological hallmark of this…”
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Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing by Marko, Daniel M, Finch, Michael S, Yang, Alex J T, Castellani, Laura N, Peppler, Willem T, Wright, David C, MacPherson, Rebecca E K

“…Exercise has been shown to be beneficial for individuals with Alzheimer's disease (AD). In rodent models of AD, exercise decreases the amyloidogenic processing…”
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Examining the effects of ovarian hormone loss and diet-induced obesity on Alzheimer's disease markers of amyloid-β production and degradation by Hayward, Grant C, Baranowski, Bradley J, Marko, Daniel M, MacPherson, Rebecca E K

“…After menopause, women experience declines in ovarian sex hormones, an event that has recently been associated with increased amyloid-β peptides, a main…”
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Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca2+ ATPase uncoupling in muscle by Geromella, Mia S., Ryan, Chantal R., Braun, Jessica L., Finch, Michael S., Maddalena, Lucas A., Bagshaw, Olivia, Hockey, Briana L., Moradi, Fereshteh, Fenech, Rachel K., Ryoo, Jisook, Marko, Daniel M., Dhaliwal, Roopan, Sweezey-Munroe, Jake, Hamstra, Sophie I., Gardner, Georgina, Silvera, Sebastian, Vandenboom, Rene, Roy, Brian D., Stuart, Jeffrey A., MacPherson, Rebecca E.K., Fajardo, Val A.

“…Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige…”
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Low-Dose Lithium Supplementation Influences GSK3β Activity in a Brain Region Specific Manner in C57BL6 Male Mice by Fenech, Rachel K, Hamstra, Sophie I, Finch, Michael S, Ryan, Chantal R, Marko, Daniel M, Roy, Brian D, Fajardo, Val A, MacPherson, Rebecca E K

“…Lithium, a commonly used treatment for bipolar disorder, has been shown to have neuroprotective effects for other conditions including Alzheimer's disease via…”
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9179 Type 2 Diabetes Alters Metabolic Fuel Selection During Intermittent Fasting by Conn, Meghan O, Marko, Daniel M, Schertzer, Jonathan D

“…Abstract Disclosure: M.O. Conn: None. D.M. Marko: None. J.D. Schertzer: None. Type 2 Diabetes Alters Metabolic Fuel Selection During Intermittent Fasting…”
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P3‐155: ROLE OF ACUTE EXERCISE‐INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1 by Baranowski, Bradley J., Hayward, Grant C., Marko, Daniel M., MacPherson, Rebecca E.K.

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ROLE OF ACUTE EXERCISE-INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1 by Baranowski, Bradley J., Hayward, Grant C., Marko, Daniel M., MacPherson, Rebecca E.K.

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Low-dose lithium supplementation promotes adipose tissue browning and sarco(endo)plasmic reticulum Ca 2+ ATPase uncoupling in muscle by Geromella, Mia S, Ryan, Chantal R, Braun, Jessica L, Finch, Michael S, Maddalena, Lucas A, Bagshaw, Olivia, Hockey, Briana L, Moradi, Fereshteh, Fenech, Rachel K, Ryoo, Jisook, Marko, Daniel M, Dhaliwal, Roopan, Sweezey-Munroe, Jake, Hamstra, Sophie I, Gardner, Georgina, Silvera, Sebastian, Vandenboom, Rene, Roy, Brian D, Stuart, Jeffrey A, MacPherson, Rebecca E K, Fajardo, Val A

“…Sarco(endo)plasmic reticulum Ca -ATPase (SERCA) uncoupling in skeletal muscle and mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige…”
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