Search Results - "Markkanen, Johanna"

Sustainable negative emissions in Europe: evaluating scenarios to meet carbon neutrality by 2050 by Markkanen, Johanna, Koponen, Kati, Lehtilä, Antti

“…Abstract Using the Pan-European TIMES-VTT model, we studied pathways for carbon neutrality by 2050 for 31 European countries by modelling a large portfolio of…”
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VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses by Rissanen, Tuomas T, Markkanen, Johanna E, Gruchala, Marcin, Heikura, Tommi, Puranen, Antti, Kettunen, Mikko I, Kholová, Ivana, Kauppinen, Risto A, Achen, Marc G, Stacker, Steven A, Alitalo, Kari, Ylä-Herttuala, Seppo

“…ABSTRACT—Optimal angiogenic and lymphangiogenic gene therapy requires knowledge of the best growth factors for each purpose. We studied the therapeutic…”
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Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart by RUTANEN, Juha, RISSANEN, Tuomas T, STACKER, Steven A, ACHEN, Marc G, HARTIKAINEN, Juha, YLÄ-HERTTUALA, Seppo, MARKKANEN, Johanna E, GRUCHALA, Marcin, SILVENNOINEN, Päivi, KIVELÄ, Antti, HEDMAN, Antti, HEDMAN, Marja, HEIKURA, Tommi, ORDEN, Maija-Riitta

“…It is unclear what is the most efficient vector and growth factor for induction of therapeutic vascular growth in the heart. Furthermore, the histological…”
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Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis by RISSANEN, Tuomas T, KORPISALO, Petra, MARKKANEN, Johanna E, LIIMATAINEN, Timo, ORDEN, Maija-Riitta, KHOLOVA, Ivana, DE GOEDE, Anna, HEIKURA, Tommi, GROHN, Olli H, YLÄ-HERTTUALA, Seppo

“…For clinically relevant proangiogenic therapy, it would be essential that the growth of the whole vascular tree is promoted. Vascular endothelial growth factor…”
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Gene Therapy for Ischemic Cardiovascular Diseases: Some Lessons Learned from the First Clinical Trials by Ylä-Herttuala, Seppo, Markkanen, Johanna E., Rissanen, Tuomas T.

“…Stimulation of angiogenesis, arteriogenesis, and lymphangiogenesis (i.e., therapeutic vascular growth) is a new concept for the treatment of ischemic…”
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Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 (KDR/Flk-1) in Ischemic Skeletal Muscle and Its Regeneration by Rissanen, Tuomas T., Vajanto, Ismo, Hiltunen, Mikko O., Rutanen, Juha, Kettunen, Mikko I., Niemi, Mari, Leppänen, Pia, Turunen, Mikko P., Markkanen, Johanna E., Arve, Katja, Alhava, Esko, Kauppinen, Risto A., Ylä-Herttuala, Seppo

“…Vascular endothelial growth factor (VEGF) is a hypoxia-inducible endothelial cell mitogen and survival factor. Its receptor VEGFR-2 (KDR/Flk-1) mediates these…”
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Novel Vascular Endothelial Growth Factor D Variants with Increased Biological Activity by Toivanen, Pyry I., Nieminen, Tiina, Viitanen, Lenita, Alitalo, Annamari, Roschier, Miia, Jauhiainen, Suvi, Markkanen, Johanna E., Laitinen, Olli H., Airenne, Tomi T., Salminen, Tiina A., Johnson, Mark S., Airenne, Kari J., Ylä-Herttuala, Seppo

“…Members of the vascular endothelial growth factor (VEGF) family play a pivotal role in angiogenesis and lymphangiogenesis. They are potential therapeutics to…”
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Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart: gene therapy by MARKKANEN, Johanna E, RISSANEN, Tuomas T, KIVELÄ, Antti, YLÄ-HERTTUALA, Seppo

“…Myocardial ischemia is one of the most promising targets of gene therapy. Although several growth factors and delivery approaches have yielded positive results…”
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Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model by Rissanen, Tuomas T, Markkanen, Johanna E, Arve, Katja, Rutanen, Juha, Kettunen, Mikko I, Vajanto, Ismo, Jauhiainen, Suvi, Cashion, Linda, Gruchala, Marcin, Närvänen, Outi, Taipale, Pekka, Kauppinen, Risto A, Rubanyi, Gabor M, Ylä-Herttuala, Seppo

“…Previous studies have shown that fibroblast growth factor (FGF)-1, FGF-2, and FGF-5 induce therapeutic angiogenesis. Here, we investigated the potential of…”
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Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs by Korpisalo, Petra, Rissanen, Tuomas T., Bengtsson, Timo, Liimatainen, Timo, Laidinen, Svetlana, Karvinen, Henna, Markkanen, Johanna E., Gröhn, Olli H., Ylä-Herttuala, Seppo

“…Aims We investigated the effects of angiogenic gene therapy with adenoviral placental growth factor131 (AdPlGF) on aerobic capacity and exercise tolerance in a…”
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Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors by Gruchała, Marcin, Bhardwaj, Shalini, Pajusola, Katri, Roy, Himadri, Rissanen, Tuomas T., Kokina, Ilze, Kholová, Ivana, Markkanen, Johanna E., Rutanen, Juha, Heikura, Tommi, Alitalo, Kari, Büeler, Hansruedi, Ylä-Herttuala, Seppo

“…Background Gene transfer offers considerable potential for altering vessel wall physiology and intervention in vascular disease. Therefore, there is great…”
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15-Lipoxygenase-1 Prevents Vascular Endothelial Growth Factor A– and Placental Growth Factor–Induced Angiogenic Effects in Rabbit Skeletal Muscles via Reduction in Growth Factor mRNA Levels, NO Bioactivity, and Downregulation of VEGF Receptor 2 Expression by Viita, Helena, Markkanen, Johanna, Eriksson, Emmi, Nurminen, Markku, Kinnunen, Kati, Babu, Mohan, Heikura, Tommi, Turpeinen, Sanna, Laidinen, Svetlana, Takalo, Teemu, Ylä-Herttuala, Seppo

“…Human 15-lipoxygenase-1 (15-LO-1) is an oxidizing enzyme capable of producing reactive lipid hydroperoxides. 15-LO-1 and its products have been suggested to be…”
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Fibroblast growth factor‐4 induces vascular permeability, angiogenesis, and arteriogenesis in a rabbit hind limb ischemia model by Rissanen, Tuomas T., Markkanen, Johanna E., Arve, Katja, Rutanen, Juha, Kettunen, Mikko I., Vajanto, Ismo, Jauhiainen, Suvi, Cashion, Linda, Gruchala, Marcin, Närvänen, Outi, Taipale, Pekka, Kauppinen, Risto A., Rubanyi, Gabor M., Ylä‐Herttuala, Seppo

“…ABSTRACT Previous studies have shown that fibroblast growth factor (FGF)‐1, FGF‐2, and FGF‐5 induce therapeutic angiogenesis. Here, we investigated the…”
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Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins by Tammela, Tuomas, He, Yulong, Lyytikkä, Johannes, Jeltsch, Michael, Markkanen, Johanna, Pajusola, Katri, Ylä-Herttuala, Seppo, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF)-C and VEGF-D are composed of the receptor-binding VEGF homology domain and a carboxy-terminal silk homology domain…”
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Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein by Keskitalo, Salla, Tammela, Tuomas, Lyytikka, Johannes, Karpanen, Terhi, Jeltsch, Michael, Markkanen, Johanna, Yla-Herttuala, Seppo, Alitalo, Kari

“…Vascular endothelial growth factor (VEGF)-C and VEGF-D require proteolytic cleavage of the carboxy terminal silk-homology domain for activation. To study the…”
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Abstract 333: Vascular Endothelial Growth Factor-B (VEGF-B) Induces Myocardium-specific Angiogenesis via VEGFR-1 and Neuropilin-1 by Markkanen, Johanna E, Nurminen, Markku T, Kivelä, Antti, Heikura, Tommi, Eriksson, Ulf, Ylä-Herttuala, Seppo

“…Abstract only Growth factor gene therapy is a new, promising tool for treatment of myocardial ischemia. Development of safe and effective clinical applications…”
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Structural pathways for permeability in the porcine and rabbit heart after intramyocardial adenoviral gene transfer of VEGF by Verheyen, Fons, Markkanen, Johanna, Ylä-Herttuala, Seppo, Waltenberger, Johannes

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Therapeutic angiogenesis induced by gene transfer of placental growth factor improves exercise tolerance of ischemic rabbit hindlimbs by Rissanen, Tuomas, Korpisalo, Petra, Bengtsson, Timo, Liimatainen, Timo, Karvinen, Henna, Markkanen, Johanna, Gröhn, Olli, Ylä-Herttuala, Seppo

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Gene therapy for restenosis: Current status by RUTANEN, Juha, MARKKANEN, Johanna, YLÄ-HERTTUALA, Seppo

“…Atherosclerosis is a major cause of morbidity and mortality in Western world. Vascular occlusion caused by atherosclerosis usually requires invasive treatment,…”
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Homology modeling of VEGF-D as a basis for structural and functional analysis by Viitanen, Lenita, Toivanen, Pyry I., Nieminen, Tiina, Alitalo, Annamari, Roschier, Miia, Jauhiainen, Suvi, Markkanen, Johanna E., Laitinen, Olli H., Airenne, Tomi T., Salminen, Tiina A., Johnson, Mark S., Airenne, Kari J., Ylä-Herttuala, Seppo

“…Abstract only…”
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