Search Results - "Markholst, H."

Antigen-dependent immunotherapy of non-obese diabetic mice with immature dendritic cells by Haase, C, Yu, L, Eisenbarth, G, Markholst, H

“…Immunotherapy can be used to induce immunological tolerance by a number of different protocols. During the last decade the ability to use tolerogenic dendritic…”
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Characteristics of Rat CD4+CD25+ T Cells and Their Ability to Prevent Not Only Diabetes But Also Insulitis in an Adoptive Transfer Model in BB Rats by Holm, T. L., Lundsgaard, D., Markholst, H.

“…Human and mouse CD4+CD25+ T cells have been intensively studied through the last decade. However, little is known about this subset in other species. This…”
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Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice by Petersen, J. S., Karlsen, A. E., Markholst, H., Worsaae, A., Dyrberg, T., Michelsen, B.

“…Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. J S Petersen , A E Karlsen ,…”
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Comparative Mapping of the Human Homologue of the Rat Diabetes Susceptibility Gene Lyp to a 1.3-Mb Segment on HSA7 by Hornum, L., Markholst, H.

“…The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1…”
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Functional rest through intensive treatment with insulin and potassium channel openers preserves residual beta-cell function and mass in acutely diabetic BB rats by Rasmussen, S B, Sørensen, T S, Hansen, J B, Mandrup-Poulsen, T, Hornum, L, Markholst, H

“…Diazoxide and the diazoxide-analogue, NNC 55-0118, are potassium channel openers that interfere with insulin secretion from beta-cells. In vitro, we show that…”
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Genetic map of the lymphopenia region on rat chromosome 4 by Hornum, L, Markholst, H

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Mapping of Zyx coding for zyxin in the rat and its exclusion as a candidate gene for lymphopenia by Hornum, L, Markholst, H

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Mapping of the rat Ptn gene to chromosome 4 by Hornum, L, Markholst, H

“…Species: Rat. Locus name: Pleiotrophin (Heparin binding factor, Hbnf, in the mouse). Locus symbol: Ptn. Map position: Chromosome (Chr) 4…”
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The rat T-cell lymphopenia resistance gene (Lyp) maps between D4Mit6 and Npy on RNO4 by Hornum, L., Jackerott, M., Markholst, H.

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Mapping of the rat Hoxa11 homeobox gene to chromosome 4 by Hornum, L, Markholst, H

“…Species: Rat. Locus name: Hoxa11 homeobox gene. Locus symbol: Hoxa11 Map position: Chromosome (Chr) 4. Try1-7.6-Npy-16.6-Hoxa11. The gene order Try1-Npy-Hoxa11…”
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The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4, a Positional Candidate of Iddm1 by Hornum, Lars, Rømer, John, Markholst, Helle

“…The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4 , a Positional Candidate of Iddm1 Lars Hornum 1 , John Rømer 2 and Helle Markholst 1 1 Type I…”
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Reduced pancreatic insulin is associated with retarded growth of the pancreas in young prediabetic BB rats by MARKHOLST, H, LERNMARK, A

“…The beta-cell function in the perfused pancreas, the total pancreatic insulin content, and the weights of pancreas, kidney, spleen, and total body fat were…”
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P014 Pharmacological evaluation of the SCID T cell transfer model of colitis by Holm, T., Poulsen, S., Markholst, H., Reedtz-Runge, S.

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In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3 by LUNDSGAARD, Dorthe, HOLM, Thomas Lindebo, HORNUM, Lars, MARKHOLST, Helle

“…In Vivo Control of Diabetogenic T-Cells by Regulatory CD4 + CD25 + T-Cells Expressing Foxp3 Dorthe Lundsgaard , Thomas Lindebo Holm , Lars Hornum and Helle…”
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Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats by Markholst, H., Klaff, L. J., Kloppel, G., Lernmark, A., Mordes, J. P., Palmer, J.

“…Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats. H Markholst , L J Klaff , G Klöppel , A Lernmark , J P Mordes and J…”
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Decreased levels of serum α-isoamylase prior to diabetes onset in BB rats by MARKHOLST, H, LAURSEN, H. V

“…The development of insulin-dependent diabetes mellitus (IDDM) includes a prodrome of autoimmunity against pancreatic beta cells. The period of subclinical…”
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Transplantation of purified islet cells in diabetic BB rats by PIPELEERS, D, PIPELEERS-MARICHAL, M, MARKHOLST, H, HOORENS, A, KLOPPEL, G

“…The ability to prepare purified islet Beta-cell aggregates was used to examine the survival of this cell type after allotransplantation in diabetic BB rats…”
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Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells by Dalberg, Ulla, Markholst, Helle, Hornum, Lars

“…Gimap5, a member of the GTPase of the immunity-associated protein family (Gimap), regulates T cell survival. A strong indication of this is found in the…”
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Insulitis and diabetes are preceded by a decrease in β cell volume in diabetes-prone BB rats by LÖHR, M, MARKHOLST, H, DYRBERG, T, KLÖPPEL, G, OBERHOLZER, M, LERNMARK, A

“…Immunocytochemistry combined with morphometry was used to test the hypothesis that insulitis and diabetes are preceded by quantitative changes in the pancreas…”
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Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo by Haase, Claus, Ejrnaes, Mette, Juedes, Amy E., Wolfe, Tom, Markholst, Helle, von Herrath, Matthias G.

“…In immunotherapy, dendritic cells (DCs) can be used as powerful antigen-presenting cells to enhance or suppress antigen-specific immunity upon in vivo transfer…”
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