Search Results - "Markham, Bruce"

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice by Markham, Bruce E, Kernodle, Stace, Nemzek, Jean, Wilkinson, John E, Sigler, Robert

“…Poloxamer 188 NF (national formulary (NF) grade of P-188) improves cardiac muscle function in the mdx mouse and golden retriever muscular dystrophy models…”
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Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain by Srivastava, Rai A K, Cornicelli, Joseph A, Markham, Bruce, Bisgaier, Charles L

“…Our clinical studies have demonstrated that gemcabene, a small molecule in late-stage clinical development, lowers pro-inflammatory acute-phase protein,…”
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The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism by Dai, Yan-Shan, Cserjesi, Peter, Markham, Bruce E., Molkentin, Jeffery D.

“…An intricate array of heterogeneous transcription factors participate in programming tissue-specific gene expression through combinatorial interactions that…”
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DT‐678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y12 antagonists by Lauver, Dale A., Kuszynski, Dawn S., Christian, Barbara D., Bernard, Matthew P., Teuber, James P., Markham, Bruce E., Chen, Yuqing E., Zhang, Haoming

“…The novel clopidogrel conjugate, DT‐678, is an effective inhibitor of platelets and thrombosis in preclinical studies. However, a comparison of the bleeding…”
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The Effects of Poloxamer-188 on Left Ventricular Function in Chronic Heart Failure After Myocardial Infarction by Juneman, Elizabeth B, Saleh, Laith, Lancaster, Jordan J, Thai, Hoang M, Markham, Bruce, Goldman, Steven

“…BACKGROUND:Poloxamer-188 (P-188) is a biological membrane sealant that prevents the unregulated entry of Ca into cardiomyocytes and has been shown to have the…”
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DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y 12 antagonists by Lauver, Dale A, Kuszynski, Dawn S, Christian, Barbara D, Bernard, Matthew P, Teuber, James P, Markham, Bruce E, Chen, Yuqing E, Zhang, Haoming

“…The novel clopidogrel conjugate, DT-678, is an effective inhibitor of platelets and thrombosis in preclinical studies. However, a comparison of the bleeding…”
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The Transcription Factors GATA4 and GATA6 Regulate Cardiomyocyte Hypertrophy in Vitro and in Vivo by Liang, Qiangrong, De Windt, Leon J., Witt, Sandra A., Kimball, Thomas R., Markham, Bruce E., Molkentin, Jeffery D.

“…The zinc finger-containing transcription factors GATA4 and GATA6 are important regulators of basal and inducible gene expression in cardiac and smooth muscle…”
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cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction by HASEGAWA, K, SOO JIN LEE, JOBE, S. M, MARKHAM, B. E, KITSIS, R. N

“…Marked alterations in the expression of specific genes occur during the development of cardiac hypertrophy in vivo. Little is known, however, about the…”
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The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes by Liang, Qiangrong, Wiese, Russell J., Bueno, Orlando F., Dai, Yan-Shan, Markham, Bruce E., Molkentin, Jeffery D.

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p300 Functions as a Coactivator of Transcription Factor GATA-4 by Dai, Yan-Shan, Markham, Bruce E.

“…Transcription factor GATA-4 plays critical roles in controlling heart development and cardiac hypertrophy. To understand how GATA-4 functions under diverse…”
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The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression by Lee, Youngsook, Shioi, Tetsuo, Kasahara, Hideko, Jobe, Shawn M., Wiese, Russell J., Markham, Bruce E., Izumo, Seigo

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Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload by Herzig, T C, Jobe, S M, Aoki, H, Molkentin, J D, Cowley, Jr, A W, Izumo, S, Markham, B E

“…Hypertrophy of mammalian cardiac muscle is mediated, in part, by angiotensin II through an angiotensin II type 1a receptor (AT 1a R)-dependent mechanism. To…”
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Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism by Srivastava, Rai Ajit K., Cornicelli, Joseph A., Markham, Bruce, Bisgaier, Charles L.

“…Inflammation plays a key role in setting the stage leading to atherosclerosis progression, and high-sensitivity C-reactive protein (CRP) has been recognized as…”
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Abstract 465: Lipid-lowering Agent Gemcabene Down-regulates Acute Phase C-reactiveProtein via /EBP-δ-mediated Transcriptional Mechanism and Attenuates Inflammation and Osteoarthritis in Animal Models by Srivastava, Rai Ajit K, Cornicelli, Joseph A, Markham, Bruce E, Bisgaier, Charles L

“…Abstract only Background: Inflammation plays a key role in setting the stage as well as causing the progression of atherosclerosis. High sensitivity c-reactive…”
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Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin.sup.-/- Mice by Markham, Bruce E, Kernodle, Stace, Nemzek, Jean, Wilkinson, John E, Sigler, Robert

“…Poloxamer 188 NF (national formulary (NF) grade of P-188) improves cardiac muscle function in the mdx mouse and golden retriever muscular dystrophy models…”
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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy by Molkentin, Jeffery D, Lu, Jian-Rong, Antos, Christopher L, Markham, Bruce, Richardson, James, Robbins, Jeffrey, Grant, Stephen R, Olson, Eric N

“…In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of…”
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ACUTE INTRAVENOUS BOLUS INJECTION OF POLOXAMER-188 IMPROVES LEFT VENTRICULAR FUNCTION IN DOGS WITH HEART FAILURE by Ilsar, Itamar, Wang, Mengjun, Jiang, Alice, Dye, Kaitlin, Markham, Bruce, Sabbah, Hani N

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Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice: e0134832 by Markham, Bruce E, Kernodle, Stace, Nemzek, Jean, Wilkinson, John E, Sigler, Robert

“…Poloxamer 188 NF (national formulary (NF) grade of P-188) improves cardiac muscle function in the mdx mouse and golden retriever muscular dystrophy models…”
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Biological Membrane Sealant Poloxamer 188 Improves Left Ventricular Function in Rats with Chronic Heart Failure by Juneman, Elizabeth, Saleh, Laith, Niazi, Tariq, Lancaster, Jordan J, Thai, Hoang, Markham, Bruce, Goldman, Steven

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Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene by Molkentin, J D, Kalvakolanu, D V, Markham, B E

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