Search Results - "Markham, Alex"

A data flow process for confidential data and its application in a health research project by Crossfield, Samantha S R, Zucker, Kieran, Baxter, Paul, Wright, Penny, Fistein, Jon, Markham, Alex F, Birkin, Mark, Glaser, Adam W, Hall, Geoff

“…The use of linked healthcare data in research has the potential to make major contributions to knowledge generation and service improvement. However, using…”
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Developing Hollow-Channel Gold Nanoflowers as Trimodal Intracellular Nanoprobes by Ye, Sunjie, Wheeler, May C, McLaughlan, James R, Tamang, Abiral, Diggle, Christine P, Cespedes, Oscar, Markham, Alex F, Coletta, P Louise, Evans, Stephen D

“…Gold nanoparticles-enabled intracellular surface-enhanced Raman spectroscopy (SERS) provides a sensitive and promising technique for single cell analysis…”
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Ketohexokinase: Expression and Localization of the Principal Fructose-metabolizing Enzyme by Diggle, Christine P, Shires, Michael, Leitch, Derek, Brooke, David, Carr, Ian M, Markham, Alex F, Hayward, Bruce E, Asipu, Aruna, Bonthron, David T

“…Ketohexokinase (KHK, also known as fructokinase) initiates the pathway through which most dietary fructose is metabolized. Very little is known about the…”
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Author Correction: A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva by Wagner, Kaitlyn, Fox, Phil, Gordon, Elizabeth, Hahn, Westen, Olsen, Kenzie, Markham, Alex, Buglewicz, Dylan, Selemenakis, Platon, Lessard, Avery, Goldstein, Daniella, Threatt, Alissa, Davis, Luke, Miller-Dawson, Jake, Stockett, Halie, Sanders, Hailey, Rugh, Kristin, Turner, Houston, Remias, Michelle, Williams, Maggie, Chavez, Jorge, Galindo, Gabriel, Cialek, Charlotte, Koch, Amanda, Fout, Alex, Fosdick, Bailey, Broeckling, Bettina, Zabel, Mark D.

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A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva by Wagner, Kaitlyn, Fox, Phil, Gordon, Elizabeth, Hahn, Westen, Olsen, Kenzie, Markham, Alex, Buglewicz, Dylan, Selemenakis, Platon, Lessard, Avery, Goldstein, Daniella, Threatt, Alissa, Davis, Luke, Miller-Dawson, Jake, Stockett, Halie, Sanders, Hailey, Rugh, Kristin, Turner, Houston, Remias, Michelle, Williams, Maggie, Chavez, Jorge, Galindo, Gabriel, Cialek, Charlotte, Koch, Amanda, Fout, Alex, Fosdick, Bailey, Broeckling, Bettina, Zabel, Mark D.

“…In response to the SARS-CoV-2 pandemic, we developed a m ulti p lexed, p aired- p ool droplet digital P CR (MP4) screening assay. Key features of our assay are…”
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Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions by Ponchel, Frederique, Toomes, Carmel, Bransfield, Kieran, Leong, Fong T, Douglas, Susan H, Field, Sarah L, Bell, Sandra M, Combaret, Valerie, Puisieux, Alain, Mighell, Alan J, Robinson, Philip A, Inglehearn, Chris F, Isaacs, John D, Markham, Alex F

“…Real-time PCR is increasingly being adopted for RNA quantification and genetic analysis. At present the most popular real-time PCR assay is based on the…”
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Neutrophil Gelatinase-associated Lipocalin as a Theragnostic Marker in Perihilar Cholangiocarcinoma by Nair, Amit, Ingram, Nicola, Verghese, Eldo T, Wijetunga, Imeshi, Markham, Alex F, Wyatt, Judy, Prasad, K Rajendra, Coletta, P Louise

“…Platforms using valid molecular targets can provide concurrent diagnostic and treatment (theragnostic) options in perihilar cholangiocarcinoma (PHC)…”
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Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease by Burn, John, Barker, William A, Markham, Alex F, Curtis, Ann, Chinnery, Patrick F, Coulthard, Alan, Fey, Constanze, Jackson, Andrew P, Jackson, Margaret J, Bates, David, Curtis, Andrew R.J, McHale, Duncan P, Bindoff, Laurence A, Ince, Paul G, Hay, David, Morris, Christopher M

“…We describe here a previously unknown, dominantly inherited, late-onset basal ganglia disease, variably presenting with extrapyramidal features similar to…”
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Identification of SATB2 as the cleft palate gene on 2q32–q33 by FitzPatrick, David R., Carr, Ian M., McLaren, Lorna, Leek, Jack P., Wightman, Patrick, Williamson, Kathy, Gautier, Philippe, McGill, Niolette, Hayward, Caroline, Firth, Helen, Markham, Alex F., Fantes, Judy A., Bonthron, David T.

“…Cytogenetic evidence, in the form of deletions and balanced translocations, points to the existence of a locus on 2q32–q33, for which haploinsufficiency…”
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DominantMapper: Rule-based analysis of SNP data for rapid mapping of dominant diseases in related nuclear families by Carr, Ian M., Johnson, Colin A., Markham, Alex F., Toomes, Carmel, Bonthron, David T., Sheridan, Eamonn G.

“…With the advent of cheap rapid methods for whole‐genome SNP genotyping and the completion of the Human Genome Project, mapping disease loci has become…”
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Herpesvirus saimiri-mediated delivery of the adenomatous polyposis coli tumour suppressor gene reduces proliferation of colorectal cancer cells by MACNAB, Stuart A, TURRELL, Susan J, CARR, Ian M, MARKHAM, Alex F, COLETTA, P. Louise, WHITEHOUSE, Adrian

“…Colorectal cancer (CRC) is a major cause of cancer-related mortality. A contributing factor to the progression of this disease is sporadic or hereditary…”
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P60. Pilot study: Profiling liposarcomas in relation to the P53-MDM axis clarifies the important interactions of mdm proteins on the bioavailability of p53 by Touqan, Nader, Verghese, Eldo T, Carr, Ian, Anwar, Rashida, Markham, Alex F, Merchant, Will, Achuthan, Rajgopal, Horgan, Kieran

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Homozygosity for a missense mutation in the 67 kDa isoform of glutamate decarboxylase in a family with autosomal recessive spastic cerebral palsy: parallels with Stiff-Person Syndrome and other movement disorders by Lynex, Clare N, Carr, Ian M, Leek, Jack P, Achuthan, Rajgopal, Mitchell, Simon, Maher, Eamonn R, Woods, C Geoffrey, Bonthon, David T, Markham, Alex F

“…Cerebral palsy (CP) is an heterogeneous group of neurological disorders of movement and/or posture, with an estimated incidence of 1 in 1000 live births…”
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Genetic heterogeneity for recessively inherited congenital cataract microcornea with corneal opacity by Khan, Kamron, Al-Maskari, Ahmed, McKibbin, Martin, Carr, Ian M, Booth, Adam, Mohamed, Moin, Siddiqui, Salina, Poulter, James A, Parry, David A, Logan, Clara V, Hashmi, Anwar, Sahi, Tehseen, Jafri, Hussain, Raashid, Yasmin, Johnson, Colin A, Markham, Alex F, Toomes, Carmel, Rice, Aine, Sheridan, Eamonn, Inglehearn, Chris F, Ali, Manir

“…To investigate whether three consanguineous families from the Punjab province of Pakistan, with affected members with recessively inherited congenital cataract…”
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Identification of FAP Locus Genes from Chromosome 5q21 by Kinzler, Kenneth W., Nilbert, Mef C., Su, Li-Kuo, Vogelstein, Bert, Bryan, Tracy M., Levy, Daniel B., Smith, Kelly J., Preisinger, Antonette C., Hedge, Philip, McKechnie, Douglas, Finniear, Rachel, Markham, Alex, Groffen, John, Boguski, Mark S., Altschul, Stephen F., Horii, Akira, Ando, Hiroshi, Miyoshi, Yasuo, Miki, Yoshio, Nishisho, Isamu, Nakamura, Yusuke

“…Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with…”
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Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients by Nishisho, Isamu, Nakamura, Yusuke, Miyoshi, Yasuo, Miki, Yoshio, Ando, Hiroshi, Horii, Akira, Koyama, Kumiko, Utsunomiya, Joji, Baba, Shozo, Hedge, Philip, Markham, Alex, Krush, Anne J., Petersen, Gloria, Hamilton, Stanley R., Nilbert, Mef C., Levy, Daniel B., Bryan, Tracy M., Preisinger, Antonette C., Smith, Kelly J., Su, Li-Kuo, Kinzler, Kenneth W., Vogelstein, Bert

“…Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's…”
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The second locus for autosomal recessive primary microcephaly (MCPH2) maps to chromosome 19q13.1-13.2 by Roberts, E, Jackson, A P, Carradice, A C, Deeble, V J, Mannan, J, Rashid, Y, Jafri, H, McHale, D P, Markham, A F, Lench, N J, Woods, C G

“…Primary microcephaly is a clinical diagnosis made when an individual has a head circumference of greater than 3 standard deviations below the age and sex…”
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Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial by Fidler, Sarah, Stöhr, Wolfgang, Pace, Matt, Dorrell, Lucy, Lever, Andrew, Pett, Sarah, Fox, Julie, Clarke, Amanda, Nelson, Mark, Thornhill, John, Khan, Maryam, Fun, Axel, Kelly, Damian, Kopycinski, Jakub, Hanke, Tomáš, Yang, Hongbing, Bennett, Rachel, Johnson, Margaret, Howell, Bonnie, Barnard, Richard, Wu, Guoxin, Wills, Mark, Babiker, Abdel, Frater, John, Sandström, Eric, Darbyshire, Janet, Post, Frank, Conlon, Christopher, Anderson, Jane, Maini, Mala, Sasieni, Peter, Weller, Ian, Fidler, Sarah, Frater, John, Babiker, Abdel, Stöhr, Wolfgang, Pett, Sarah, Pace, Matthew, Brown, Helen, Kopycinski, Jakub, Yang, Hongbing, Hanke, Tomáš, Crook, Alison, Kaye, Steven, McClure, Myra, Erlwein, Otto, Lovell, Andrew, Khan, Maryam, Gabrielle, Michelle, Bennett, Rachel, Sy, Aminata, Gregory, Adam, Hudson, Fleur, Russell, Charlotte, Wood, Gemma, Box, Hanna, Kingsley, Cherry, Topping, Katie, Wills, Mark, Fun, Axel, Bandara, Mikaila, Kelly, Damian, Collins, Simon, Rauchenberger, Mary, Sowunmi, Yinka, Shidfar, Shaadi, Nelson, Mark, Castrillo Martinez, Nadia, Barber, Tristan, Schoolmeesters, Alexandra, Weaver, Christine, Thunder, Orla, Rowlands, Jane, Higgs, Christopher, Bracchi, Margherita, Bourke, Peter, Lawrenson, Gaynor, Fiorino, Marzia, Lukha, Hinal, Kinloch-de Loes, Sabine, Johnson, Margaret, Nightingale, Alice, Ngwu, Nnenna, Byrne, Patrick, Cuthbertson, Zoe, Jones, Martin, Fernandez, Tina, Fisher, Martin, Trevitt, Vittorio, Fitzpatrick, Colin, Adams, Tanya, Thornhill, John, Lewis, Heather, Kuldanek, Kristin, Fox, Julie, Uzu, Hiromi, O'Rourke, Patrick, Taylor, Mark, Tiraboschi, Juan Manuel, Murray, Tammy

“…Antiretroviral therapy (ART) cannot cure HIV infection because of a persistent reservoir of latently infected cells. Approaches that force HIV transcription…”
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Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis by Jones, Elena A., English, Anne, Henshaw, Karen, Kinsey, Sally E., Markham, Alex F., Emery, Paul, McGonagle, Dennis

“…Objective To evaluate synovial fluid (SF) for the presence of mesenchymal progenitor cells (MPCs), to compare SF MPCs with bone marrow (BM) MPCs, and to…”
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The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression by Goodwin, Delyth J, Hall, Kersten T, Giles, Mathew S, Calderwood, Michael A, Markham, Alex F, Whitehouse, Adrian

“…Molecular Medicine Unit, University of Leeds, St James’s University Hospital, Leeds LS9 7TF, UK 1 Author for correspondence: Adrian Whitehouse. Fax +44 113 244…”
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