Search Results - "Markad, Shankar D"

Synthesis of Pentahydroxy Indolizidine Alkaloids Using Ring Closing Metathesis:  Attempts To Find the Correct Structure of Uniflorine A by Karanjule, Narayan S, Markad, Shankar D, Dhavale, Dilip D

“…Ring closing metathesis of d-glucose derived diene-substrate containing nitrogen functionality followed by asymmetric dihydroxylation afforded sugar…”
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Whole cell screen based identification of spiropiperidines with potent antitubercular properties by Tantry, Subramanyam J., Degiacomi, Giulia, Sharma, Sreevalli, Jena, Lalit kumar, Narayan, Ashwini, Guptha, Supreeth, Shanbhag, Gajanan, Menasinakai, Sreenivasaiah, Mallya, Meenakshi, Awasthy, Disha, Balakrishnan, Gayathri, Kaur, Parvinder, Bhattacharjee, Deepa, Narayan, Chandan, Reddy, Jitendar, Naveen Kumar, C.N., Shandil, Radha, Boldrin, Francesca, Ventura, Marcello, Manganelli, Riccardo, Hartkoorn, Ruben C., Cole, Stewart T., Panda, Manoranjan, Markad, Shankar D., Ramachandran, Vasanthi, Ghorpade, Sandeep R., Dinesh, Neela

“…[Display omitted] Whole cell based screens to identify hits against Mycobacterium tuberculosis (Mtb), carried out under replicating and non-replicating (NRP)…”
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Intramolecular 5-endo-Trig Aminomercuration of β-Hydroxy-γ-alkenylamines:  Efficient Route to a Pyrrolidine Ring and Its Application for the Synthesis of (+)-Castanospermine and Analogues by Karanjule, Narayan S, Markad, Shankar D, Shinde, Vaishali S, Dhavale, Dilip D

“…The intramolecular aminomercuration reaction of sugar-derived β-hydroxy-γ-alkenylamines 8a−c undergoes 5-endo-trig cyclization in high yield. The…”
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Temporary Carbohydrate Diol Protection with Ester Groups – Orthogonality under Solid‐Phase Oligosaccharide Synthesis Conditions by Markad, Shankar D., Schmidt, Richard R.

“…For regioselective deprotection studies under SPOS conditions the glucosamine derivatives 4ab/4ba, 4ac/4ca and 4ad/4da – with Fmoc/PA, Fmoc/Lev or Fmoc/Alloc,…”
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Asymmetric Dihydroxylation of d-Glucose Derived α,β-Unsaturated Ester:  Synthesis of Azepane and Nojirimycin Analogues by Dhavale, Dilip D, Markad, Shankar D, Karanjule, Narayan S, PrakashaReddy, J

“…The asymmetric dihydroxylation of a d-glucose derived α,β-unsaturated ester 3 afforded syn vicinal diols in good to high diastereoselectivity. The conversion…”
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Stereoselectivity in the Epoxidation of Carbohydrate-Based Oxepines by Markad, Shankar D, Xia, Shijing, Snyder, Nicole L, Surana, Bikash, Morton, Martha D, Hadad, Christopher M, Peczuh, Mark W

“…The facial selectivity in the DMDO epoxidation of carbohydrate-based oxepines derived from glucose, galactose, and mannose has been determined by product…”
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Computational and experimental investigations of mono-septanoside binding by Concanavalin A: correlation of ligand stereochemistry to enthalpies of binding by Duff, Jr, Michael R, Fyvie, W Sean, Markad, Shankar D, Frankel, Alexandra E, Kumar, Challa V, Gascón, José A, Peczuh, Mark W

“…Structure-energy relationships for a small group of pyranose and septanose mono-saccharide ligands are developed for binding to Concanavalin A (ConA). The…”
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1,3-Dipolar Cycloaddition Reaction of d-Glucose-Derived Nitrone with Allyl Alcohol:  Synthesis of 2-Hydroxy-1-deoxycastanospermine Analogues by Karanjule, Narayan S, Markad, Shankar D, Sharma, Tarun, Sabharwal, Sushma G, Puranik, Vedavati G, Dhavale, Dilip D

“…The synthesis and evaluation of glycosidase inhibitory activity of polyhydroxylated indolizidine alkaloids namely 2-hydroxy-1-deoxycastanospermine 3a,b and…”
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Synthesis and evaluation of glycosidase inhibitory activity of N-butyl 1-deoxy- d- gluco-homonojirimycin and N-butyl 1-deoxy- l- ido-homonojirimycin by Markad, Shankar D., Karanjule, Narayan S., Sharma, Tarun, Sabharwal, Sushma G., Dhavale, Dilip D.

“…Conjugate addition of n-butyl amine to d-glucose derived α,β-unsaturated ester 4 afforded β-amino esters 5a, b that on reduction of ester group, 1,2-acetonide…”
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Polyhydroxylated homoazepanes and 1-deoxy-homonojirimycin analogues: Synthesis and glycosidase inhibition study by Markad, Shankar D, Karanjule, Narayan S, Sharma, Tarun, Sabharwal, Sushma G, Dhavale, Dilip D

“…The Johnson-Claisen rearrangement of D-gluco and L-ido-derived allylic orthoesters afforded gamma,delta-unsaturated ester that on ester reduction, epoxidation,…”
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Discovery of Imidazo[1,2‑a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis by Tantry, Subramanyam J, Markad, Shankar D, Shinde, Vikas, Bhat, Jyothi, Balakrishnan, Gayathri, Gupta, Amit K, Ambady, Anisha, Raichurkar, Anandkumar, Kedari, Chaitanyakumar, Sharma, Sreevalli, Mudugal, Naina V, Narayan, Ashwini, Naveen Kumar, C. N, Nanduri, Robert, Bharath, Sowmya, Reddy, Jitendar, Panduga, Vijender, Prabhakar, K. R, Kandaswamy, Karthikeyan, Saralaya, Ramanatha, Kaur, Parvinder, Dinesh, Neela, Guptha, Supreeth, Rich, Kirsty, Murray, David, Plant, Helen, Preston, Marian, Ashton, Helen, Plant, Darren, Walsh, Jarrod, Alcock, Peter, Naylor, Kathryn, Collier, Matthew, Whiteaker, James, McLaughlin, Robert E, Mallya, Meenakshi, Panda, Manoranjan, Rudrapatna, Suresh, Ramachandran, Vasanthi, Shandil, Radha, Sambandamurthy, Vasan K, Mdluli, Khisi, Cooper, Christopher B, Rubin, Harvey, Yano, Takahiro, Iyer, Pravin, Narayanan, Shridhar, Kavanagh, Stefan, Mukherjee, Kakoli, Balasubramanian, V, Hosagrahara, Vinayak P, Solapure, Suresh, Ravishankar, Sudha, Hameed P, Shahul

“…The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacterium…”
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Hydroxyl group orientation affects hydrolysis rates of methyl α-septanosides by Markad, Shankar D., Miller, Shawn M., Morton, Martha, Peczuh, Mark W.

“…Hydrolysis rates for three related methyl α-septanosides were obtained. The septanosides were synthesized via mCPBA epoxidation and methanolysis of d-mannose,…”
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Novel lead generation of an anti-tuberculosis agent active against non-replicating mycobacteria: exploring hybridization of pyrazinamide with multiple fragments by Markad, Shankar D., Kaur, Parvinder, Kishore Reddy, B. K., Chinnapattu, Murugan, Raichurkar, Anandkumar, Nandishaiah, Radha, Panda, Manoranjan, Iyer, Pravin S.

“…The key to shortening tuberculosis (TB) drug regimen lies in eliminating the reservoir of non-replicating persistent (NRP) Mycobacterium tuberculosis (Mtb)…”
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