Search Results - "Mark S. Cooper"

Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases by Hardy, Rowan S., Raza, Karim, Cooper, Mark S.

“…Therapeutic glucocorticoids have been widely used in rheumatic diseases since they became available over 60 years ago. Despite the advent of more specific…”
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Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 by Annane, Djillali, Pastores, Stephen M., Rochwerg, Bram, Arlt, Wiebke, Balk, Robert A., Beishuizen, Albertus, Briegel, Josef, Carcillo, Joseph, Christ-Crain, Mirjam, Cooper, Mark S., Marik, Paul E., Umberto Meduri, Gianfranco, Olsen, Keith M., Rodgers, Sophia, Russell, James A., Van den Berghe, Greet

“…Objective To update the 2008 consensus statements for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult…”
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Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 by Annane, Djillali, Pastores, Stephen M., Rochwerg, Bram, Arlt, Wiebke, Balk, Robert A., Beishuizen, Albertus, Briegel, Josef, Carcillo, Joseph, Christ-Crain, Mirjam, Cooper, Mark S., Marik, Paul E., Umberto Meduri, Gianfranco, Olsen, Keith M., Rodgers, Sophia C., Russell, James A., Van den Berghe, Greet

“…OBJECTIVE:To update the 2008 consensus statements for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult…”
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Glucocorticoid-Induced Psychosis in Children and Adolescents: A Systematic Review by Fani-Molky, Parisa, Bradley, Jarrod, Cooper, Mark S

“…Knowledge is limited regarding the adverse effects of therapeutic glucocorticoids on pediatric mental health outcomes. Glucocorticoid-induced psychosis (GIP)…”
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Critical illness-related corticosteroid insufficiency (CIRCI): a narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) by Annane, Djillali, Pastores, Stephen M., Arlt, Wiebke, Balk, Robert A., Beishuizen, Albertus, Briegel, Josef, Carcillo, Joseph, Christ-Crain, Mirjam, Cooper, Mark S., Marik, Paul E., Meduri, Gianfranco Umberto, Olsen, Keith M., Rochwerg, Bram, Rodgers, Sophia C., Russell, James A., Van den Berghe, Greet

“…Objective To provide a narrative review of the latest concepts and understanding of the pathophysiology of critical illness-related corticosteroid…”
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Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives by Seibel, Markus J, Prof, Cooper, Mark S, Prof, Zhou, Hong, MD

“…Summary Glucocorticoids are widely used for their unsurpassed anti-inflammatory and immunomodulatory effects. However, the therapeutic use of glucocorticoids…”
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Corticosteroid Insufficiency in Acutely Ill Patients by Cooper, Mark S, Stewart, Paul M

“…Recent studies report benefits from corticosteroid treatment in patients with septic shock. This review summarizes the physiology of the corticosteroid…”
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Association between bone mineral density and C-reactive protein in a large population-based sample by de Pablo, Paola, Cooper, Mark S., Buckley, Christopher D.

“…Objective Several studies suggest that bone mineral density (BMD) is reduced in chronic inflammatory diseases. Higher serum levels of C‐reactive protein (CRP)…”
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Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe by Martin, Claire S, Cooper, Mark S, Hardy, Rowan S

“…The role of tissue specific metabolism of endogenous glucocorticoids (GCs) in the pathogenesis of human disease has been a field of intense interest over the…”
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Vitamin D to Prevent Lung Injury Following Esophagectomy—A Randomized, Placebo-Controlled Trial by Parekh, Dhruv, Dancer, Rachel C. A., Scott, Aaron, D’Souza, Vijay K., Howells, Phillip A., Mahida, Rahul Y., Tang, Jonathan C. Y., Cooper, Mark S., Fraser, William D., Tan, LamChin, Gao, Fang, Martineau, Adrian R., Tucker, Olga, Perkins, Gavin D., Thickett, David R.

“…OBJECTIVES:Observational studies suggest an association between vitamin D deficiency and adverse outcomes of critical illness and identify it as a potential…”
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Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis by Webster, Justine M, Sagmeister, Michael S, Fenton, Chloe G, Seabright, Alex P, Lai, Yu-Chiang, Jones, Simon W, Filer, Andrew, Cooper, Mark S, Lavery, Gareth G, Raza, Karim, Langen, Ramon, Hardy, Rowan S

“…Glucocorticoids provide indispensable anti-inflammatory therapies. However, metabolic adverse effects including muscle wasting restrict their use. The enzyme…”
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11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation by Fenton, Chloe G, Crastin, Ana, Martin, Claire S, Suresh, Saicharan, Montagna, Isabella, Hussain, Bismah, Naylor, Amy J, Jones, Simon W, Hansen, Morten S, Gorvin, Caroline M, Price, Maria, Filer, Andrew, Cooper, Mark S, Lavery, Gareth G, Raza, Karim, Hardy, Rowan S

“…Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management of chronic inflammatory diseases such as rheumatoid arthritis (RA)…”
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Inactivation of the CIC-DUX4 oncogene through P300/CBP inhibition, a therapeutic approach for CIC-DUX4 sarcoma by Bosnakovski, Darko, Ener, Elizabeth T., Cooper, Mark S., Gearhart, Micah D., Knights, Kevin A., Xu, Natalie C., Palumbo, Christian A., Toso, Erik A., Marsh, Graham P., Maple, Hannah J., Kyba, Michael

“…CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the…”
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Dihydrotestosterone (DHT) Enhances Wound Healing of Major Burn Injury by Accelerating Resolution of Inflammation in Mice by Shi, Huaikai, Lo, Tsun-Ho, Ma, Duncan, Condor, Brenton, Lesmana, Brian, Parungao, Roxanne J, Tsai, Kevin H-Y, Kim, Sarah, Chen, Hsiao-Ting, Silveira, Pablo A, Li, Zhe, Cooper, Mark S, Simanainen, Ulla, Handelsman, David J, Maitz, Peter K, Wang, Yiwei

“…Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was…”
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Glucocorticoid metabolism in rheumatoid arthritis by Hardy, Rowan S., Raza, Karim, Cooper, Mark S.

“…Endogenous glucocorticoids are implicated in the development and resolution of inflammation. Until recently it was thought that these glucocorticoids arose…”
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Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy by Hardy, Rowan S, Zhou, Hong, Seibel, Markus J, Cooper, Mark S

“…Osteoporosis associated with long-term glucocorticoid therapy remains a common and serious bone disease. Additionally, in recent years it has become clear that…”
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Glucocorticoids in bone and joint disease: the good, the bad and the uncertain by Cooper, Mark S.

“…Therapeutic glucocorticoids are widely used to treat a variety of inflammatory conditions. However, the beneficial anti-inflammatory effects of glucocorticoids…”
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Disorders of calcium metabolism and parathyroid disease by Cooper, Mark S., BA, BMBCh, MRCP, PhD

“…Pregnancy and lactation are associated with profound changes in calcium physiology. This can make interpretation of biochemical tests difficult during these…”
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Sensitivity of bone to glucocorticoids by Cooper, Mark S

“…Glucocorticoids are used widely in a range of medical specialities, but their main limitation is an adverse impact on bone. Although physicians are…”
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Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice by Henneicke, Holger, Kim, Sarah, Swarbrick, Michael M., Li, Jingbao, Gasparini, Sylvia J., Thai, Joanne, Foong, Daphne, Cavanagh, Lauryn L., Fong-Yee, Colette, Karsten, Elisabeth, Lin, Ruby C.Y., Cooper, Mark S., Zhou, Hong, Seibel, Markus J.

“…Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis…”
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