Search Results - "Mark Okon"

Arginine: Its pKa value revisited by Fitch, Carolyn A, Platzer, Gerald, Okon, Mark, Garcia-Moreno, Bertrand E, McIntosh, Lawrence P

“…Using complementary approaches of potentiometry and NMR spectroscopy, we have determined that the equilibrium acid dissociation constant (pKa value) of the…”
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Biophysical characterization of the ETV6 PNT domain polymerization interfaces by Gerak, Chloe A.N., Cho, Sophia Y., Kolesnikov, Maxim, Okon, Mark, Murphy, Michael E.P., Sessions, Richard B., Roberge, Michel, McIntosh, Lawrence P.

“…ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding…”
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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins by Boyko, Kristina V, Rosenkranz, Erin A, Smith, Derrick M, Miears, Heather L, Oueld Es Cheikh, Melissa, Lund, Micah Z, Young, Jeffery C, Reardon, Patrick N, Okon, Mark, Smirnov, Serge L, Antos, John M

“…A significant number of proteins possess sizable intrinsically disordered regions (IDRs). Due to the dynamic nature of IDRs, NMR spectroscopy is often the tool…”
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Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor by Desjardins, Geneviève, Meeker, Charles A., Bhachech, Niraja, Currie, Simon L., Okon, Mark, Graves, Barbara J., McIntosh, Lawrence P.

“…The E26 transformation-specific (Ets-1) transcription factor is autoinhibited by a conformationally disordered serine-rich region (SRR) that transiently…”
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The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body by Bergeron, Julien R.C., Worrall, Liam J., De, Soumya, Sgourakis, Nikolaos G., Cheung, Adrienne H., Lameignere, Emilie, Okon, Mark, Wasney, Gregory A., Baker, David, McIntosh, Lawrence P., Strynadka, Natalie C.J.

“…The type III secretion system (T3SS) is a large macromolecular assembly found at the surface of many pathogenic Gram-negative bacteria. Its role is to inject…”
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Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells by Singh, Chaahat S. B., Eyford, Brett A., Abraham, Thomas, Munro, Lonna, Choi, Kyung Bok, Okon, Mark, Vitalis, Timothy Z., Gabathuler, Reinhard, Lu, Chieh-Ju, Pfeifer, Cheryl G., Tian, Mei Mei, Jefferies, Wilfred A.

“…The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of diseases of the brain. Our previous studies demonstrated that…”
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Antibody recognition of a unique tumor-specific glycopeptide antigen by Brooks, Cory L, Schietinger, Andrea, Borisova, Svetlana N, Kufer, Peter, Okon, Mark, Hirama, Tomoko, MacKenzie, C. Roger, Wang, Lai-Xi, Schreiber, Hans, Evans, Stephen V

“…Aberrant glycosylation and the overexpression of certain carbohydrate moieties is a consistent feature of cancers, and tumor-associated oligosaccharides are…”
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A Protein Export Pathway Involving Escherichia coli Porins by Prehna, Gerd, Zhang, Guijin, Gong, Xiandi, Duszyk, Marek, Okon, Mark, McIntosh, Lawrence P., Weiner, Joel H., Strynadka, Natalie C.J.

“…Escherichia coli export the protein YebF into the extracellular medium by a two-step process. However, as no general outer membrane protein secretion system…”
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pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements by Platzer, Gerald, Okon, Mark, McIntosh, Lawrence P.

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Structure, dynamics, and ionization equilibria of the tyrosine residues in Bacillus circulans xylanase by Baturin, Simon J., Okon, Mark, McIntosh, Lawrence P.

“…We have developed NMR spectroscopic methods to investigate the tyrosines within Bacillus circulans xylanase (BcX). Four slowly exchanging buried tyrosine…”
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Structural Characterization of the Type-III Pilot-Secretin Complex from Shigella flexneri by Okon, Mark, Moraes, Trevor F., Lario, Paula I., Creagh, A. Louise, Haynes, Charles A., Strynadka, Natalie C.J., McIntosh, Lawrence P.

“…Assembly of the type-III secretion apparatus, which translocates proteins through both membranes of Gram-negative bacterial pathogens into host cells, requires…”
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pH-dependent random coil (1)H, (13)C, and (15)N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements by Platzer, Gerald, Okon, Mark, McIntosh, Lawrence P

“…The pK a values and charge states of ionizable residues in polypeptides and proteins are frequently determined via NMR-monitored pH titrations. To aid the…”
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Structural and Dynamic Independence of Isopeptide-linked RanGAP1 and SUMO-1 by Macauley, Matthew S., Errington, Wesley J., Okon, Mark, Schärpf, Manuela, Mackereth, Cameron D., Schulman, Brenda A., McIntosh, Lawrence P.

“…Although sumoylation regulates a diverse and growing number of recognized biological processes, the molecular mechanisms by which the covalent attachment of…”
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Unambiguous Determination of the Ionization State of a Glycoside Hydrolase Active Site Lysine by 1H−15N Heteronuclear Correlation Spectroscopy by Poon, David K. Y, Schubert, Mario, Au, Jason, Okon, Mark, Withers, Stephen G, McIntosh, Lawrence P

“…We have investigated the lysine side chain amines in the 34 kDa catalytic domain from Cellulomonas fimi β-(1,4)-glycosidase Cex (or CfXyn10A) using 1H-detected…”
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Ligand- and pH-Induced Structural Transition of Gypsy Moth Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1) by Terrado, Mailyn, Okon, Mark, McIntosh, Lawrence P, Plettner, Erika

“…Pheromone-binding proteins (PBPs) are small, water-soluble proteins found in the lymph of pheromone-sensing hairs. PBPs are essential in modulating pheromone…”
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O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers by Yuzwa, Scott A., Cheung, Adrienne H., Okon, Mark, McIntosh, Lawrence P., Vocadlo, David J.

“…The aggregation of the microtubule-associated protein tau into paired helical filaments to form neurofibrillary tangles constitutes one of the pathological…”
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The p K a values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme by Brockerman, Jacob A., Okon, Mark, Withers, Stephen G., McIntosh, Lawrence P.

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Structural and Dynamics Studies of Pax5 Reveal Asymmetry in Stability and DNA Binding by the Paired Domain by Perez-Borrajero, Cecilia, Okon, Mark, McIntosh, Lawrence P.

“…The eukaryotic transcription factor Pax5 or B-cell specific activator protein (BSAP) is central to B-cell development and has been implicated in a large number…”
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Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods by Majewski, Dorothy D., Okon, Mark, Heinkel, Florian, Robb, Craig S., Vuckovic, Marija, McIntosh, Lawrence P., Strynadka, Natalie C.J.

“…The type III secretion system (T3SS) is a multi-membrane-spanning protein channel used by Gram-negative pathogenic bacteria to secrete effectors directly into…”
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Structural Transitions as Determinants of the Action of the Calcium-Dependent Antibiotic Daptomycin by Jung, David, Rozek, Annett, Okon, Mark, Hancock, Robert E.W

“…Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent…”
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