Search Results - "Mark A. Jarosinski"

Structural principles of insulin formulation and analog design: A century of innovation by Jarosinski, Mark A., Dhayalan, Balamurugan, Chen, Yen-Shan, Chatterjee, Deepak, Varas, Nicolás, Weiss, Michael A.

“…The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the…”
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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation by Dhayalan, Balamurugan, Glidden, Michael D, Zaykov, Alexander N, Chen, Yen-Shan, Yang, Yanwu, Phillips, Nelson B, Ismail-Beigi, Faramarz, Jarosinski, Mark A, DiMarchi, Richard D, Weiss, Michael A

“…The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin's biosynthetic precursor. Also designated (MIDY),…”
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‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues by Jarosinski, Mark A., Dhayalan, Balamurugan, Rege, Nischay, Chatterjee, Deepak, Weiss, Michael A.

“…Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or…”
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New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals by Jarosinski, Mark A, Chen, Yen-Shan, Varas, Nicolás, Dhayalan, Balamurugan, Chatterjee, Deepak, Weiss, Michael A

“…Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmacokinetic (PK) and…”
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Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation by Chen, Yen-Shan, Gleaton, Jeremy, Yang, Yanwu, Dhayalan, Balamurugan, Phillips, Nelson B., Liu, Yule, Broadwater, Laurie, Jarosinski, Mark A., Chatterjee, Deepak, Lawrence, Michael C., Hattier, Thomas, Michael, M. Dodson, Weiss, Michael A.

“…Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to…”
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Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi by Barrios, Victor E., Jarosinski, Mark A., Wright, Clifford D.

“…The mast cell serine protease tryptase has been implicated as a critical mediator of airway hyperresponsiveness in vitro and in vivo. We have previously…”
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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2 by FOTSCH, Christopher, SMITH, Duncan M, TAMAYO, Nuria A, NING XI, BAUMGARTNER, James W, ADAMS, Jeffrey A, CHEETHAM, Janet, CROGHAN, Michael, DOHERTY, Elizabeth M, HALE, Clarence, JAROSINSKI, Mark A, KELLY, Michael G, NORMAN, Mark H

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE by Vassar, Robert, Bennett, Brian D., Babu-Khan, Safura, Kahn, Steve, Mendiaz, Elizabeth A., Denis, Paul, Teplow, David B., Ross, Sandra, Amarante, Patricia, Loeloff, Richard, Luo, Yi, Fisher, Seth, Fuller, Janis, Edenson, Steven, Lile, Jackson, Jarosinski, Mark A., Biere, Anja Leona, Curran, Eileen, Burgess, Teresa, Louis, Jean-Claude, Collins, Frank, Treanor, James, Rogers, Gary, Citron, Martin

“…Cerebral deposition of amyloid β peptide (Aβ) is an early and critical feature of Alzheimer's disease. Aβ generation depends on proteolytic cleavage of the…”
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Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr by Feigon, Juli, Dieckmann, Thorsten, Withers-Ward, Elizabeth S, Jarosinski, Mark A, Liu, Chuan-Fa, Chen, Irvin S. Y

“…The HIV-1 protein Vpr is critical for a number of viral functions including a unique ability to arrest T-cells at a G2/M checkpoint and induce subsequent…”
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Solid-Phase Synthesis via 5-Oxazolidinones. Ring-Opening Reactions with Amines and Reaction Monitoring by Single-Bead FT-IR Microspectroscopy by Marti, Roger E, Yan, Bing, Jarosinski, Mark A

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Synthesis, chemical reactivity, and antitumor evaluation of congeners of carmethizole hydrochloride, an experimental acylated vinylogous carbinolamine tumor inhibitor by Jarosinski, Mark A, Reddy, Peech S, Anderson, Wayne K

“…A series of analogues of 4,5-bis(((N-methylcarbamoyl)oxy)methyl)-1-methyl-2-(methylthio)-im idazole (1, carmethizole) were synthesized. The chemical…”
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Lanthionine macrocyclization by in situ activation of serine by MAYER, JOHN P., ZHANG, JINGWEN, GROEGER, STEFAN, LIU, CHUAN-FA, JAROSINSKI, MARK A.

“…The present report details a straightforward, solid‐phase approach to cyclolanthionine peptides. After stepwise assembly of the linear sequence and…”
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Preparation of noncondensed 2-substituted 1-methylimidazoles via ipso substitution reaction on 2-sulfinyl or 2-sulfonyl derivatives of 4,5-disubstituted 1-methylimidazoles by Jarosinski, Mark A, Anderson, Wayne K

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Synthesis of 3-pyrrolines by an intramolecular Wittig reaction by Kinder, Frederick R, Jarosinski, Mark A, Anderson, Wayne K

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Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs by Biere, Anja Leona, Wood, Stephen J., Wypych, Jette, Steavenson, Shirley, Jiang, Yijia, Anafi, Dan, Jacobsen, Frederick W., Jarosinski, Mark A., Wu, Gay-May, Louis, Jean-Claude, Martin, Francis, Narhi, Linda O., Citron, Martin

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two…”
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Enhanced resolution in MAS NMR for combinatorial chemistry by Shapiro, Michael J., Chin, Jefferson, Marti, Roger E., Jarosinski, Mark A.

“…We have demonstrated the ability to obtain high resolution NMR spectra from samples on resin using J-resolved 2D NMR. Projection of the non-tilted spectrum…”
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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2) by Fotsch, Christopher, Smith, Duncan M, Adams, Jeffrey A, Cheetham, Janet, Croghan, Michael, Doherty, Elizabeth M, Hale, Clarence, Jarosinski, Mark A, Kelly, Michael G, Norman, Mark H, Tamayo, Nuria A, Xi, Ning, Baumgartner, James W

“…The solution structure of a potent melanocortin receptor agonist, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2) (1) was calculated using distance restraints…”
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Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2 by Fotsch, Christopher, Smith, Duncan M, Adams, Jeffrey A, Cheetham, Janet, Croghan, Michael, Doherty, Elizabeth M, Hale, Clarence, Jarosinski, Mark A, Kelly, Michael G, Norman, Mark H, Tamayo, Nuria A, Xi, Ning, Baumgartner, James W

“…The solution structure of a potent melanocortin receptor agonist, Ac-Nle-cyclo[Asp-Pro- dPhe-Arg-Trp-Lys]-NH 2 ( 1) was calculated using distance restraints…”
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Parkinson's Disease-associated α-Synuclein Is More Fibrillogenic than β- and γ-Synuclein and Cannot Cross-seed Its Homologs by Anja Leona Biere, Stephen J. Wood, Jette Wypych, Shirley Steavenson, Yijia Jiang, Dan Anafi, Frederick W. Jacobsen, Mark A. Jarosinski, Gay-May Wu, Jean-Claude Louis, Francis Martin, Linda O. Narhi, Martin Citron

“…Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two…”
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[Beta]-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE by Vassar, Robert, Bennett, Brian D, Babu-Khan, Safura, Kahn, Steve, Mendiaz, Elizabeth A, Denis, Paul, Teplow, David B, Ross, Sandra, Amarante, Patricia, Loeloff, Richard, Luo, Yi, Fisher, Seth, Fuller, Janis, Edenson, Steven, Lile, Jackson, Jarosinski, Mark A, Biere, Anja Leona, Curran, Eileen, Burgess, Teresa, Louis, Jean-Claude, Collins, Frank, Treanor, James, Rogers, Gary, Citron, Martin

“…Cerebral deposition of amyloid [Beta] peptide (A[Beta]) is an early and critical feature of Alzheimer's disease. A[Beta] generation depends on proteolytic…”
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