Search Results - "Mark, P"
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Ongoing Clinical Trials for the Management of the COVID-19 Pandemic
Published in Trends in pharmacological sciences (Regular ed.) (01-06-2020)“…COVID-19 has rapidly developed into a worldwide pandemic with a significant health and economic burden. There are currently no approved treatments or…”
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2
Effects of Intermittent Fasting on Health, Aging, and Disease
Published in The New England journal of medicine (26-12-2019)“…Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with…”
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Brain metabolism in health, aging, and neurodegeneration
Published in The EMBO journal (01-06-2017)“…Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing activity in neuronal circuits, and from environmental energetic…”
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4
Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease
Published in Cell metabolism (05-12-2012)“…Evolution favored individuals with superior cognitive and physical abilities under conditions of limited food sources, and brain function can therefore be…”
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Published in Cell metabolism (05-06-2018)“…During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised bioenergetics, impaired adaptive neuroplasticity and resilience,…”
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Lifestyle and periodontitis: The emergence of personalized periodontics
Published in Periodontology 2000 (01-10-2018)“…Personalized medicine is a medical model that involves the tailoring of healthcare ‐ with medical decisions, practices, and/or products being customized to an…”
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Fasting: Molecular Mechanisms and Clinical Applications
Published in Cell metabolism (04-02-2014)“…Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage…”
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Large scale brain models of epilepsy: dynamics meets connectomics
Published in Journal of neurology, neurosurgery and psychiatry (01-12-2012)“…The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The…”
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Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease
Published in Annals of the New York Academy of Sciences (01-11-2008)“…Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but glutamate has since been shown to regulate neurogenesis, neurite outgrowth,…”
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10
Host modulation: controlling the inflammation to control the infection
Published in Periodontology 2000 (01-10-2017)“…Historically, periodontal disease (gingivitis and periodontitis) has been recognized as being primarily of bacterial origin. However, recent evidence indicates…”
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Periodontal health
Published in Journal of clinical periodontology (01-06-2018)“…Objectives To date there is a paucity of documentation regarding definitions of periodontal health. This review considers the histological and clinical…”
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12
An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition
Published in Trends in cognitive sciences (01-03-2019)“…Brain structures and neuronal networks that mediate spatial navigation, decision-making, sociality, and creativity evolved, in part, to enable success in food…”
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13
Impact of Intermittent Fasting on Health and Disease Processes
Published in Ageing research reviews (01-10-2017)“…Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food…”
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14
BDNF mediates adaptive brain and body responses to energetic challenges
Published in Trends in endocrinology and metabolism (01-02-2014)“…Highlights • Energetic challenges (e.g., exercise and energy restriction) induce BDNF signaling. • BDNF enhances neuronal bioenergetics and promotes optimal…”
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15
Effective field theory of dark matter and structure formation: Semianalytical results
Published in Physical review. D, Particles, fields, gravitation, and cosmology (25-02-2014)“…Complimenting recent work on the effective field theory of cosmological large scale structures, here we present detailed approximate analytical results and…”
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16
On inflation with non-minimal coupling
Published in The journal of high energy physics (01-11-2010)“…A simple realization of inflation consists of adding the following operators to the Einstein-Hilbert action: ( ∂ϕ ) 2 , λϕ 4 , and ξϕ 2 R , with ξ a large…”
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Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease
Published in Neurobiology of disease (01-05-2020)“…Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has…”
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18
Neural‐Symbolic Machine Learning for Retrosynthesis and Reaction Prediction
Published in Chemistry : a European journal (02-05-2017)“…Reaction prediction and retrosynthesis are the cornerstones of organic chemistry. Rule‐based expert systems have been the most widespread approach to…”
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19
Periodontal health
Published in Journal of periodontology (1970) (01-06-2018)“…Objectives To date there is a paucity of documentation regarding definitions of periodontal health. This review considers the histological and clinical…”
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20
Can field portable X-ray fluorescence (pXRF) produce high quality data for application in environmental contamination research?
Published in Environmental pollution (1987) (01-07-2016)“…This research evaluates the analytical capabilities of a field portable X-ray fluorescence spectrometer (pXRF) for the measurement of contaminated soil samples…”
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