Search Results - "Mario T. Philipp"

Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain by Ramesh, Geeta, MacLean, Andrew G., Philipp, Mario T.

“…Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central…”
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Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding by Embers, Monica E, Hasenkampf, Nicole R, Jacobs, Mary B, Tardo, Amanda C, Doyle-Meyers, Lara A, Philipp, Mario T, Hodzic, Emir

“…The efficacy and accepted regimen of antibiotic treatment for Lyme disease has been a point of significant contention among physicians and patients. While…”
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Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity by Lin, Tao, Gao, Lihui, Zhang, Chuhua, Odeh, Evelyn, Jacobs, Mary B, Coutte, Loïc, Chaconas, George, Philipp, Mario T, Norris, Steven J

“…The identification of genes important in the pathogenesis of Lyme disease Borrelia has been hampered by exceedingly low transformation rates in low-passage,…”
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Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection by Embers, Monica E, Barthold, Stephen W, Borda, Juan T, Bowers, Lisa, Doyle, Lara, Hodzic, Emir, Jacobs, Mary B, Hasenkampf, Nicole R, Martin, Dale S, Narasimhan, Sukanya, Phillippi-Falkenstein, Kathrine M, Purcell, Jeanette E, Ratterree, Marion S, Philipp, Mario T

“…The persistence of symptoms in Lyme disease patients following antibiotic therapy, and their causes, continue to be a matter of intense controversy. The…”
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Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi by Parthasarathy, Geetha, Philipp, Mario T

“…In previous studies, human oligodendrocytes were demonstrated to undergo apoptosis in the presence of Borrelia burgdorferi under an inflammatory milieu…”
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A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi by Ramesh, Geeta, Benge, Shemi, Pahar, Bapi, Philipp, Mario T

“…Inflammation caused by the Lyme disease spirochete B. burgdorferi is an important factor in the pathogenesis of Lyme neuroborreliosis. Our central hypothesis…”
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Repeated Tick Infestations Impair Borrelia burgdorferi Transmission in a Non-Human Primate Model of Tick Feeding by Narasimhan, Sukanya, Booth, Carmen J, Philipp, Mario T, Fikrig, Erol, Embers, Monica E

“…The blacklegged tick, , is the predominant vector of , the agent of Lyme disease in the USA. Natural hosts of such as are repeatedly infested by these ticks…”
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Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P by Burmeister, Amanda R, Johnson, M Brittany, Chauhan, Vinita S, Moerdyk-Schauwecker, Megan J, Young, Ada D, Cooley, Ian D, Martinez, Alejandra N, Ramesh, Geeta, Philipp, Mario T, Marriott, Ian

“…The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed…”
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Interleukin-10 Alters Effector Functions of Multiple Genes Induced by Borrelia burgdorferi in Macrophages To Regulate Lyme Disease Inflammation by GAUTAM, Aarti, DIXIT, Saurabh, PHILIPP, Mario T, SINGH, Shree R, MORICI, Lisa A, KAUSHAL, Deepak, DENNIS, Vida A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Antibiotics Doxycycline and Minocycline Inhibit the Inflammatory Responses to the Lyme Disease Spirochete Borrelia burgdorferi by Bernardino, Andrea L. F., Kaushal, Deepak, Philipp, Mario T.

“…Tetracyclines moderate inflammatory responses of various etiologies. We hypothesized that tetracyclines, in addition to their antimicrobial function, could…”
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Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi by Lin, Tao, Gao, Lihui, Edmondson, Diane G, Jacobs, Mary B, Philipp, Mario T, Norris, Steven J

“…Antigenic variation plays a vital role in the pathogenesis of many infectious bacteria and protozoa including Borrelia burgdorferi, the causative agent of Lyme…”
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Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells by Myers, Tereance A, Kaushal, Deepak, Philipp, Mario T

“…Inflammation has long been implicated as a contributor to pathogenesis in many CNS illnesses, including Lyme neuroborreliosis. Borrelia burgdorferi is the…”
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Live Borrelia burgdorferi Spirochetes Elicit Inflammatory Mediators from Human Monocytes via the Toll-Like Receptor Signaling Pathway by Dennis, Vida A, Dixit, Saurabh, O'Brien, Shannon M, Alvarez, Xavier, Pahar, Bapi, Philipp, Mario T

“…We investigated the mechanisms that lead to the production of proinflammatory mediators by human monocytes when these cells are exposed in vitro to live…”
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Different patterns of expression and of IL-10 modulation of inflammatory mediators from macrophages of Lyme disease-resistant and -susceptible mice by Gautam, Aarti, Dixit, Saurabh, Embers, Monica, Gautam, Rajeev, Philipp, Mario T, Singh, Shree R, Morici, Lisa, Dennis, Vida A

“…C57BL/6J (C57) mice develop mild arthritis (Lyme disease-resistant) whereas C3H/HeN (C3H) mice develop severe arthritis (Lyme disease-susceptible) after…”
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Toll-Like Receptors: Insights into Their Possible Role in the Pathogenesis of Lyme Neuroborreliosis by BERNARDINO, Andrea L. F, MYERS, Tereance A, ALVAREZ, Xavier, HASEGAWA, Atsuhiko, PHILIPP, Mario T

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Serodiagnosis of Lyme Disease by Kinetic Enzyme-Linked Immunosorbent Assay Using Recombinant VlsE1 or Peptide Antigens of Borrelia burgdorferi Compared with 2-Tiered Testing Using Whole-Cell Lysates by Bacon, Rendi Murphree, Biggerstaff, Brad J., Schriefer, Martin E., Gilmore, Robert D., Philipp, Mario T., Steere, Allen C., Wormser, Gary P., Marques, Adriana R., Johnson, Barbara J. B.

“…In a study of US patients with Lyme disease, immunoglobulin (Ig) G and IgM antibody responses to recombinant Borrelia burgdorferi antigen VlsE1 (rVlsE1), IgG…”
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Review: apoptotic mechanisms in bacterial infections of the central nervous system by Parthasarathy, Geetha, Philipp, Mario T

“…In this article we review the apoptotic mechanisms most frequently encountered in bacterial infections of the central nervous system (CNS). We focus…”
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Dynamic Longitudinal Antibody Responses during Borrelia burgdorferi Infection and Antibiotic Treatment of Rhesus Macaques by Embers, Monica E, Hasenkampf, Nicole R, Jacobs, Mary B, Philipp, Mario T

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model by Pflughoeft, Kathryn J, Mash, Michael, Hasenkampf, Nicole R, Jacobs, Mary B, Tardo, Amanda C, Magee, D Mitchell, Song, Lusheng, LaBaer, Joshua, Philipp, Mario T, Embers, Monica E, AuCoin, David P

“…The identification of microbial biomarkers is critical for the diagnosis of a disease early during infection. However, the identification of reliable…”
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Possible role of glial cells in the onset and progression of Lyme neuroborreliosis by Ramesh, Geeta, Borda, Juan T, Gill, Amy, Ribka, Erin P, Morici, Lisa A, Mottram, Peter, Martin, Dale S, Jacobs, Mary B, Didier, Peter J, Philipp, Mario T

“…Lyme neuroborreliosis (LNB) may present as meningitis, cranial neuropathy, acute radiculoneuropathy or, rarely, as encephalomyelitis. We hypothesized that…”
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