Search Results - "Marino, Joseph"

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy by Seo, Kinya, Rainer, Peter P., Hahn, Virginia Shalkey, Lee, Dong-ik, Jo, Su-Hyun, Andersen, Asger, Liu, Ting, Xu, Xiaoping, Willette, Robert N., Lepore, John J., Marino, Joseph P., Birnbaumer, Lutz, Schnackenberg, Christine G., Kass, David A.

“…Chronic neurohormonal and mechanical stresses are central features of heart disease. Increasing evidence supports a role for the transient receptor potential…”
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The glucocorticoid receptor: cause of or cure for obesity? by John, Kezia, Marino, Joseph S, Sanchez, Edwin R, Hinds, Jr, Terry D

“…Glucocorticoid hormones (GCs) are important regulators of lipid metabolism, promoting lipolysis with acute treatment but lipogenesis with chronic exposure…”
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High Fat Rodent Models of Type 2 Diabetes: From Rodent to Human by Stott, Nicole L, Marino, Joseph S

“…Poor dietary habits contribute to increased incidences of obesity and related co-morbidities, such as type 2 diabetes (T2D). The biological, genetic, and…”
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Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins by Linder, Monika I., Köhler, Mario, Boersema, Paul, Weberruss, Marion, Wandke, Cornelia, Marino, Joseph, Ashiono, Caroline, Picotti, Paola, Antonin, Wolfram, Kutay, Ulrike

“…During interphase, the nuclear envelope (NE) serves as a selective barrier between cytosol and nucleoplasm. When vertebrate cells enter mitosis, the NE is…”
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Central insulin and leptin-mediated autonomic control of glucose homeostasis by Marino, Joseph S, Xu, Yong, Hill, Jennifer W

“…Largely as a result of rising obesity rates, the incidence of type 2 diabetes is escalating rapidly. Type 2 diabetes results from multi-organ dysfunctional…”
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Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α by Marino, Joseph S., Stechschulte, Lance A., Stec, David E., Nestor-Kalinoski, Andrea, Coleman, Sydni, Hinds, Terry D.

“…Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic gluconeogenesis during fasting. Long-term GC treatment induces hepatic…”
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Association of Opioids and Sedatives with Increased Risk of In-Hospital Cardiopulmonary Arrest from an Administrative Database by Overdyk, Frank J, Dowling, Oonagh, Marino, Joseph, Qiu, Jiejing, Chien, Hung-Lun, Erslon, Mary, Morrison, Neil, Harrison, Brooke, Dahan, Albert, Gan, Tong J

“…While opioid use confers a known risk for respiratory depression, the incremental risk of in-hospital cardiopulmonary arrest, respiratory arrest, or…”
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Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle by Peck, Bailey, Huot, Josh, Renzi, Tim, Arthur, Susan, Turner, Michael J, Marino, Joseph S

“…Protein kinase C-θ (PKC-θ) is a lipid-sensitive molecule associated with lipid-induced insulin resistance in skeletal muscle. Rodent models have not cohesively…”
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Editorial: Debates in elite sports and performance enhancement: 2022 by Beato, Marco, Marino, Joseph S, Dello Iacono, Antonio

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Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT) by Ding, Yun, Belyanskaya, Svetlana, DeLorey, Jennifer L., Messer, Jeffrey A., Joseph Franklin, G., Centrella, Paolo A., Morgan, Barry A., Clark, Matthew A., Skinner, Steven R., Dodson, Jason W., Li, Peng, Marino, Joseph P., Israel, David I.

“…[Display omitted] Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease…”
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Delayed Puberty but Normal Fertility in Mice With Selective Deletion of Insulin Receptors From Kiss1 Cells by Qiu, Xiaoliang, Dowling, Abigail R, Marino, Joseph S, Faulkner, Latrice D, Bryant, Benjamin, Brüning, Jens C, Elias, Carol F, Hill, Jennifer W

“…Pubertal onset only occurs in a favorable, anabolic hormonal environment. The neuropeptide kisspeptin, encoded by the Kiss1 gene, modifies GnRH neuronal…”
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The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore by Washburn, David G., Holt, Dennis A., Dodson, Jason, McAtee, Jeff J., Terrell, Lamont R., Barton, Linda, Manns, Sharada, Waszkiewicz, Anna, Pritchard, Christina, Gillie, Dan J., Morrow, Dwight M., Davenport, Elizabeth A., Lozinskaya, Irina M., Guss, Jeffrey, Basilla, Jonathan B., Negron, Lorena Kallal, Klein, Michael, Willette, Robert N., Fries, Rusty E., Jensen, Timothy C., Xu, Xiaoping, Schnackenberg, Christine G., Marino, Joseph P.

“…Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the identification of analogs which displayed low nanomolar blocking…”
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Overexpression of Glucocorticoid Receptor β Enhances Myogenesis and Reduces Catabolic Gene Expression by Hinds, Terry D, Peck, Bailey, Shek, Evan, Stroup, Steven, Hinson, Jennifer, Arthur, Susan, Marino, Joseph S

“…Unlike the glucocorticoid receptor α (GRα), GR β (GRβ) has a truncated ligand-binding domain that prevents glucocorticoid binding, implicating GRα as the…”
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Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery by Marino, Jr, Joseph P

“…Soluble epoxide hydrolase (sEH) is a cross-functional target, with the potential for therapeutic utility in the areas of hypertension, inflammation, and…”
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Glucocorticoid resistance remodels liver lipids and prompts lipogenesis, eicosanoid, and inflammatory pathways by Martinez, Genesee J., Kipp, Zachary A., Lee, Wang-Hsin, Bates, Evelyn A., Morris, Andrew J., Marino, Joseph S., Hinds, Terry D.

“…We have previously demonstrated that the glucocorticoid receptor β (GRβ) isoform induces hepatic steatosis in mice fed a normal chow diet. The GRβ isoform…”
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Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN by Stechschulte, Lance A., Wuescher, Leah, Marino, Joseph S., Hill, Jennifer W., Eng, Charis, Hinds, Terry D.

“…Glucocorticoids (GCs) are known inhibitors of proliferation and are commonly prescribed to cancer patients to inhibit tumor growth and induce apoptosis via the…”
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Enantioselective Synthesis of Dihydro‑1H‑benzindoles by Silveira, Gustavo P, Marino, Joseph P

“…The first examples of dihydro-1H-benzindoles by enantioselective γ-lactamization reaction of naphthyl sulfilimines with trichloroacetyl chloride in the…”
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Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays by Zeng, Xin, Kirkpatrick, Robert, Hofmann, Glenn, Grillot, Didier, Linhart, Valerie, Viviani, Fabrice, Marino, Jr, Joseph, Boyer, Joseph, Graham, Taylor L, Lu, Quinn, Wu, Zining, Benowitz, Andrew, Cousins, Rick

“…Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of…”
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In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor by Podolin, Patricia L., Bolognese, Brian J., Foley, Joseph F., Long, Edward, Peck, Brian, Umbrecht, Sandra, Zhang, Xiaojun, Zhu, Penny, Schwartz, Benjamin, Xie, Wensheng, Quinn, Chad, Qi, Hongwei, Sweitzer, Sharon, Chen, Stephanie, Galop, Marc, Ding, Yun, Belyanskaya, Svetlana L., Israel, David I., Morgan, Barry A., Behm, David J., Marino, Joseph P., Kurali, Edit, Barnette, Mary S., Mayer, Ruth J., Booth-Genthe, Catherine L., Callahan, James F.

“…► A novel, potent, selective inhibitor of human, rat and mouse sEH, GSK2256294A, is described. ► In vitro, GSK2256294A exhibits concentration-dependent…”
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Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation by Marino, Joseph S, Iler, Jeffrey, Dowling, Abigail R, Chua, Streamson, Bruning, Jens C, Coppari, Roberto, Hill, Jennifer W

“…Clinical research shows an association between polycystic ovary syndrome (PCOS) and chronic inflammation, a pathological state thought to contribute to insulin…”
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