Search Results - "Marinko, Justin T."

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis by Marinko, Justin T, Huang, Hui, Penn, Wesley D, Capra, John A, Schlebach, Jonathan P, Sanders, Charles R

“…Advances over the past 25 years have revealed much about how the structural properties of membranes and associated proteins are linked to the thermodynamics…”
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Peripheral myelin protein 22 alters membrane architecture by Mittendorf, Kathleen F, Marinko, Justin T, Hampton, Cheri M, Ke, Zunlong, Hadziselimovic, Arina, Schlebach, Jonathan P, Law, Cheryl L, Li, Jun, Wright, Elizabeth R, Sanders, Charles R, Ohi, Melanie D

“…Peripheral myelin protein 22 (PMP22) is highly expressed in myelinating Schwann cells of the peripheral nervous system. genetic alterations cause the most…”
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Peripheral myelin protein 22 preferentially partitions into ordered phase membrane domains by Marinko, Justin T., Kenworthy, Anne K., Sanders, Charles R.

“…The ordered environment of cholesterol-rich membrane nanodomains is thought to exclude many transmembrane (TM) proteins. Nevertheless, some multispan helical…”
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Direct relationship between increased expression and mistrafficking of the Charcot–Marie–Tooth–associated protein PMP22 by Marinko, Justin T., Carter, Bruce D., Sanders, Charles R.

“…Charcot–Marie–Tooth disease (CMT) is a neuropathy of the peripheral nervous system that afflicts ∼1:2500 people. The most common form of this disease (CMT1A,…”
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How T118M peripheral myelin protein 22 predisposes humans to Charcot–Marie–Tooth disease by Stefanski, Katherine M., Li, Geoffrey C., Marinko, Justin T., Carter, Bruce D., Samuels, David C., Sanders, Charles R.

“…Data from gnomAD indicate that a missense mutation encoding the T118M variation in human peripheral myelin protein 22 (PMP22) is found in roughly one of every…”
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Reply to Record et al. “The role of PMP22 T118M in Charcot–Marie–Tooth disease remains unsolved” by Stefanski, Katherine M., Li, Geoffrey C., Marinko, Justin T., Carter, Bruce D., Samuels, David C., Sanders, Charles R.

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Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22 by Marinko, Justin T., Wright, Madison T., Schlebach, Jonathan P., Clowes, Katherine R., Heintzman, Darren R., Plate, Lars, Sanders, Charles R.

“…Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior…”
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Direct relationship between increased expression and mistrafficking of the Charcot-Marie-Tooth-associated protein PMP22 by Marinko, Justin T, Carter, Bruce D, Sanders, Charles R

“…Charcot-Marie-Tooth disease (CMT) is a neuropathy of the peripheral nervous system that afflicts ∼1:2500 people. The most common form of this disease (CMT1A,…”
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