Search Results - "Marini, Frank"

Tumor-associated stromal cells as key contributors to the tumor microenvironment by Bussard, Karen M, Mutkus, Lysette, Stumpf, Kristina, Gomez-Manzano, Candelaria, Marini, Frank C

“…The tumor microenvironment is a heterogeneous population of cells consisting of the tumor bulk plus supporting cells. It is becoming increasingly evident that…”
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Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma by Kidd, Shannon, Spaeth, Erika, Watson, Keri, Burks, Jared, Lu, Hongbo, Klopp, Ann, Andreeff, Michael, Marini, Frank C

“…To meet the requirements for rapid tumor growth, a complex array of non-neoplastic cells are recruited to the tumor microenvironment. These cells facilitate…”
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Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth? by Klopp, Ann H., Gupta, Anshul, Spaeth, Erika, Andreeff, Michael, Marini, Frank

“…The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a great deal of interest over the past decade in the function of MSCs in…”
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Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment by Kolb, Alexus D, Shupp, Alison B, Mukhopadhyay, Dimpi, Marini, Frank C, Bussard, Karen M

“…In a cancer-free environment in the adult, the skeleton continuously undergoes remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and…”
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Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL‐6/gp130/STAT3 Pathway by Hossain, Anwar, Gumin, Joy, Gao, Feng, Figueroa, Javier, Shinojima, Naoki, Takezaki, Tatsuya, Priebe, Waldemar, Villarreal, Diana, Kang, Seok‐Gu, Joyce, Celine, Sulman, Erik, Wang, Qianghu, Marini, Frank C., Andreeff, Michael, Colman, Howard, Lang, Frederick F.

“…Although mesenchymal stem cells (MSCs) have been implicated as stromal components of several cancers, their ultimate contribution to tumorigenesis and their…”
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Direct Evidence of Mesenchymal Stem Cell Tropism for Tumor and Wounding Microenvironments Using In Vivo Bioluminescent Imaging by Kidd, Shannon, Spaeth, Erika, Dembinski, Jennifer L., Dietrich, Martin, Watson, Keri, Klopp, Ann, Battula, Venkata Lokesh, Weil, Micheal, Andreeff, Michael, Marini, Frank C.

“…Multipotent mesenchymal stromal/stem cells (MSC) have shown potential clinical utility. However, previous assessments of MSC behavior in recipients have relied…”
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Human omental-derived adipose stem cells increase ovarian cancer proliferation, migration, and chemoresistance by Nowicka, Aleksandra, Marini, Frank C, Solley, Travis N, Elizondo, Paula B, Zhang, Yan, Sharp, Hadley J, Broaddus, Russell, Kolonin, Mikhail, Mok, Samuel C, Thompson, Melissa S, Woodward, Wendy A, Lu, Karen, Salimian, Bahar, Nagrath, Deepak, Klopp, Ann H

“…Adipose tissue contains a population of multipotent adipose stem cells (ASCs) that form tumor stroma and can promote tumor progression. Given the high rate of…”
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Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression by Spaeth, Erika L, Dembinski, Jennifer L, Sasser, A Kate, Watson, Keri, Klopp, Ann, Hall, Brett, Andreeff, Michael, Marini, Frank

“…Tumor associated fibroblasts (TAF), are essential for tumor progression providing both a functional and structural supportive environment. TAF, known as…”
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Indocyanine Green-Loaded Nanoparticles for Image-Guided Tumor Surgery by Hill, Tanner K, Abdulahad, Asem, Kelkar, Sneha S, Marini, Frank C, Long, Timothy E, Provenzale, James M, Mohs, Aaron M

“…Detecting positive tumor margins and local malignant masses during surgery is critical for long-term patient survival. The use of image-guided surgery for…”
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Epithelial‐Mesenchymal Transition‐Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells by Battula, Venkata Lokesh, Evans, Kurt William, Hollier, Brett George, Shi, Yuexi, Marini, Frank C., Ayyanan, Ayyakkannu, Wang, Rui‐yu, Brisken, Cathrin, Guerra, Rudy, Andreeff, Michael, Mani, Sendurai A.

“…The epithelial‐to‐mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction…”
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Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis by Battula, Venkata Lokesh, Shi, Yuexi, Evans, Kurt W, Wang, Rui-Yu, Spaeth, Erika L, Jacamo, Rodrigo O, Guerra, Rudy, Sahin, Aysegul A, Marini, Frank C, Hortobagyi, Gabriel, Mani, Sendurai A, Andreeff, Michael

“…Cancer stem cells (CSCs) are a small subpopulation of cancer cells that have increased resistance to conventional therapies and are capable of establishing…”
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Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus Δ24-RGD to Human Gliomas by YONG, Raymund L, SHINOJIMA, Naoki, FUEYO, Juan, GUMIN, Joy, VECIL, Giacomo G, MARINI, Frank C, BOGLER, Oliver, ANDREEFF, Michael, LANG, Frederick F

“…Δ24-RGD is an infectivity-augmented, conditionally replicative oncolytic adenovirus with significant antiglioma effects. Although intratumoral delivery of…”
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Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies by Leach, Timothy, Gandhi, Uma, Reeves, Kimberly D., Stumpf, Kristina, Okuda, Kenichi, Marini, Frank C., Walker, Stephen J., Boucher, Richard, Chan, Jeannie, Cox, Laura A., Atala, Anthony, Murphy, Sean V.

“…The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment…”
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Imaging of Fibroblast Activation Protein Alpha Expression in a Preclinical Mouse Model of Glioma Using Positron Emission Tomography by Pandya, Darpan N, Sinha, Akesh, Yuan, Hong, Mutkus, Lysette, Stumpf, Kristina, Marini, Frank C, Wadas, Thaddeus J

“…Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous system. Due to the lack of effective treatment options, the…”
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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia by Konopleva, Marina, Contractor, Rooha, Tsao, Twee, Samudio, Ismael, Ruvolo, Peter P., Kitada, Shinichi, Deng, Xingming, Zhai, Dayong, Shi, Yue-Xi, Sneed, Thomas, Verhaegen, Monique, Soengas, Maria, Ruvolo, Vivian R., McQueen, Teresa, Schober, Wendy D., Watt, Julie C., Jiffar, Tilahun, Ling, Xiaoyang, Marini, Frank C., Harris, David, Dietrich, Martin, Estrov, Zeev, McCubrey, James, May, W. Stratford, Reed, John C., Andreeff, Michael

“…BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity…”
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HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts by Ko, Song Yi, Barengo, Nicolas, Ladanyi, Andras, Lee, Ju-Seog, Marini, Frank, Lengyel, Ernst, Naora, Honami

“…Epithelial ovarian cancers (EOCs) often exhibit morphologic features of embryonic Müllerian duct-derived tissue lineages and colonize peritoneal surfaces that…”
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Near infrared fluorescent nanoparticles based on hyaluronic acid: Self-assembly, optical properties, and cell interaction by Kelkar, Sneha S., Hill, Tanner K., Marini, Frank C., Mohs, Aaron M.

“…[Display omitted] Fluorescent imaging agents that can specifically highlight tumor cells could have a significant impact on image-guided tumor removal. Here,…”
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pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells by Coffelt, Seth B, Marini, Frank C, Watson, Keri, Zwezdaryk, Kevin J, Dembinski, Jennifer L, LaMarca, Heather L, Tomchuck, Suzanne L, zu Bentrup, Kerstin Honer, Danka, Elizabeth S, Henkle, Sarah L, Scandurro, Aline B

“…Bone marrow-derived mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) have been shown to engraft into the stroma of several tumor types,…”
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Mesenchymal CD44 Expression Contributes to the Acquisition of an Activated Fibroblast Phenotype via TWIST Activation in the Tumor Microenvironment by SPAETH, Erika L, LABAFF, Adam M, TOOLE, Bryan P, KLOPP, Ann, ANDREEFF, Michael, MARINI, Frank C

“…Tumor-stroma interactions play a crucial role in cancer progression by eliciting factors that promote proliferative, angiogenic, and invasive supports to the…”
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TGF-β Mediates Homing of Bone Marrow―Derived Human Mesenchymal Stem Cells to Glioma Stem Cells by SHINOJIMA, Naoki, HOSSAIN, Anwar, LANG, Frederick F, TAKEZAKI, Tatsuya, FUEYO, Juan, GUMIN, Joy, GAOL, Feng, NWAJEI, Felix, MARINI, Frank C, ANDREEFF, Michael, KURATSU, Jun-Ichi

“…Although studies have suggested that bone marrow human mesenchymal stem cells (BM-hMSC) may be used as delivery vehicles for cancer therapy, it remains unclear…”
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