Oocyte cryopreservation for future fertility: comparison of ovarian response between cancer and non-cancer patients

This study aimed to assess whether a diagnosis of cancer interferes with ovarian function prior to the treatment of the disease. This observational retrospective study used data from medical records of ovarian stimulation cycles performed for purposes of oocyte cryopreservation. The included patient...

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Bibliographic Details
Published in:	JBRA assisted reproduction Vol. 23; no. 2; pp. 91 - 98
Main Authors:	Moraes, Camila Cruz de, Marinho, Victoria Furquim Werneck, Campos, Ana Luísa Menezes, Guedes, Janaína de Souza, Xavier, Érica Becker de Sousa, Caetano, João Pedro Junqueira, Marinho, Ricardo Mello
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction) 2019 Brazilian Society of Assisted Reproduction
Subjects:	Breast cancer Cancer therapies Cryopreservation Disease Embryos Gynecology In vitro fertilization Infertility Laboratories Medical prognosis Original Patients Quality standards Reproductive technologies Standard deviation Statistical analysis Womens health Brazil cancer fertility preservation oncofertility Oocyte cryopreservation
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Summary:	This study aimed to assess whether a diagnosis of cancer interferes with ovarian function prior to the treatment of the disease. This observational retrospective study used data from medical records of ovarian stimulation cycles performed for purposes of oocyte cryopreservation. The included patients had a mean age of 35.13±3.72 years and 51.6% of them were aged between 36 and 40 years. More than half of the patients (57.6%) were single and 82.1% had a normal body mass index (BMI). Most women had not become pregnant (85.5%) or had babies (95.1%) or miscarriages (89.6%) prior to cryopreservation. The mean number of oocytes obtained from non-cancer patients was 11.4±8, while for cancer patients the number was 13.8±9. The mean number of frozen mature oocytes was 9.7±7 for the non-cancer group and 11.2±7.2 for the cancer group. The majority (63.1%) of the patients had up to 10 oocytes frozen per cycle. Breast cancer had the highest incidence among the included patients. There was no significant difference in ovarian response between patients with different types of cancer. The number of harvested and frozen oocytes from cancer and non-cancer patients indicated that in the two groups response to ovarian stimulation was similar.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1518-0557 1517-5693 1518-0557
DOI:	10.5935/1518-0557.20190010