Search Results - "Marineau, Jason J."

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 by Hu, Shanhu, Marineau, Jason J, Rajagopal, Nisha, Hamman, Kristin B, Choi, Yoon Jong, Schmidt, Darby R, Ke, Nan, Johannessen, Liv, Bradley, Michael J, Orlando, David A, Alnemy, Sydney R, Ren, Yixuan, Ciblat, Stephane, Winter, Dana K, Kabro, Anzhelika, Sprott, Kevin T, Hodgson, J Graeme, Fritz, Christian C, Carulli, John P, di Tomaso, Emmanuelle, Olson, Eric R

“…Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant…”
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Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent by Xiang, Michael, Kim, Haesook, Ho, Vincent T., Walker, Sarah R., Bar-Natan, Michal, Anahtar, Melodi, Liu, Suhu, Toniolo, Patricia A., Kroll, Yasmin, Jones, Nichole, Giaccone, Zachary T., Heppler, Lisa N., Ye, Darwin Q., Marineau, Jason J., Shaw, Daniel, Bradner, James E., Blonquist, Traci, Neuberg, Donna, Hetz, Claudio, Stone, Richard M., Soiffer, Robert J., Frank, David A.

“…The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of…”
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Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7 by Marineau, Jason J, Hamman, Kristin B, Hu, Shanhu, Alnemy, Sydney, Mihalich, Janessa, Kabro, Anzhelika, Whitmore, Kenneth Matthew, Winter, Dana K, Roy, Stephanie, Ciblat, Stephane, Ke, Nan, Savinainen, Anneli, Wilsily, Ashraf, Malojcic, Goran, Zahler, Robert, Schmidt, Darby, Bradley, Michael J, Waters, Nigel J, Chuaqui, Claudio

“…CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and…”
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Genome-wide localization of small molecules by Anders, Lars, Guenther, Matthew G, Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Lovén, Jakob, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E, Young, Richard A

“…A new method called Chem-seq reveals the genomic binding sites of drugs that target DNA and chromatin. A vast number of small-molecule ligands, including…”
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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors by Yu, Wenyu, Chory, Emma J., Wernimont, Amy K., Tempel, Wolfram, Scopton, Alex, Federation, Alexander, Marineau, Jason J., Qi, Jun, Barsyte-Lovejoy, Dalia, Yi, Joanna, Marcellus, Richard, Iacob, Roxana E., Engen, John R., Griffin, Carly, Aman, Ahmed, Wienholds, Erno, Li, Fengling, Pineda, Javier, Estiu, Guillermina, Shatseva, Tatiana, Hajian, Taraneh, Al-awar, Rima, Dick, John E., Vedadi, Masoud, Brown, Peter J., Arrowsmith, Cheryl H., Bradner, James E., Schapira, Matthieu

“…Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development…”
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Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription by Rimel, Jenna K, Poss, Zachary C, Erickson, Benjamin, Maas, Zachary L, Ebmeier, Christopher C, Johnson, Jared L, Decker, Tim-Michael, Yaron, Tomer M, Bradley, Michael J, Hamman, Kristin B, Hu, Shanhu, Malojcic, Goran, Marineau, Jason J, White, Peter W, Brault, Martine, Tao, Limei, DeRoy, Patrick, Clavette, Christian, Nayak, Shraddha, Damon, Leah J, Kaltheuner, Ines H, Bunch, Heeyoun, Cantley, Lewis C, Geyer, Matthias, Iwasa, Janet, Dowell, Robin D, Bentley, David L, Old, William M, Taatjes, Dylan J

“…CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few…”
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Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors by McKeown, Michael R, Shaw, Daniel L, Fu, Harry, Liu, Shuai, Xu, Xiang, Marineau, Jason J, Huang, Yibo, Zhang, Xiaofeng, Buckley, Dennis L, Kadam, Asha, Zhang, Zijuan, Blacklow, Stephen C, Qi, Jun, Zhang, Wei, Bradner, James E

“…BET bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer. Structural analogy of…”
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Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement by Yi, Joanna S, Federation, Alexander J, Qi, Jun, Dhe-Paganon, Sirano, Hadler, Michael, Xu, Xiang, St. Pierre, Roodolph, Varca, Anthony C, Wu, Lei, Marineau, Jason J, Smith, William B, Souza, Amanda, Chory, Emma J, Armstrong, Scott A, Bradner, James E

“…The DOT1L lysine methyltransferase has emerged as a validated therapeutic target in MLL-rearranged (MLLr) acute leukemias. Although S-adenosylmethionine…”
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Development and Evaluation of a Solid-Supported Cyclobutadieneiron Tricarbonyl Complex for Parallel Synthesis Applications by Marineau, Jason J, Snapper, Marc L

“…Cycloadditions of cyclobutadiene can offer rapid access to rigid polycyclic ring systems. Further functionalization of these strained-ring cycloadducts can…”
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7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: Readily accessible and highly potent anticancer compounds by D’Erasmo, Michael P., Smith, William B., Munoz, Alberto, Mohandas, Poornima, Au, Andrew S., Marineau, Jason J., Quadri, Luis E.N., Bradner, James E., Murelli, Ryan P.

“…7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single…”
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Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors by Yu, Wenyu, Chory, Emma J, Wernimont, Amy K, Tempel, Wolfram, Scopton, Alex, Federation, Alexander, Marineau, Jason J, Qi, Jun, Barsyte-lovejoy, Dalia, Yi, Joanna, Marcellus, Richard, Iacob, Roxana E, Engen, John R, Griffin, Carly, Aman, Ahmed, Wienholds, Erno, Li, Fengling, Pineda, Javier, Estiu, Guillermina, Shatseva, Tatiana, Hajian, Taraneh, Al-awar, Rima, Dick, John E, Vedadi, Masoud, Brown, Peter J, Arrowsmith, Cheryl H, Bradner, James E, Schapira, Matthieu

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Abstract 3230: Genome-wide localization of anti-cancer drugs by Anders, Lars, Guenther, Matthew G., Qi, Jun, Fan, Zi Peng, Marineau, Jason J., Rahl, Peter B., Lovén, Jakob, Sigova, Alla A., Smith, William B., Lee, Tong Ihn, Bradner, James E., Young, Richard A.

“…Abstract A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific…”
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Genome-wide determination of drug localization by Anders, Lars, Guenther, Matthew G., Qi, Jun, Fan, Zi Peng, Marineau, Jason J., Rahl, Peter B., Lovén, Jakob, Sigova, Alla A., Smith, William B., Lee, Tong Ihn, Bradner, James E., Young, Richard A.

“…A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins…”
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Correction: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors by Yu, Wenyu, Chory, Emma J., Wernimont, Amy K., Tempel, Wolfram, Scopton, Alex, Federation, Alexander, Marineau, Jason J., Qi, Jun, Barsyte-Lovejoy, Dalia, Yi, Joanna, Marcellus, Richard, Iacob, Roxana E., Engen, John R., Griffin, Carly, Aman, Ahmed, Wienholds, Erno, Li, Fengling, Pineda, Javier, Estiu, Guillermina, Shatseva, Tatiana, Hajian, Taraneh, Al-awar, Rima, Dick, John E., Vedadi, Masoud, Brown, Peter J., Arrowsmith, Cheryl H., Bradner, James E., Schapira, Matthieu

“…Nature Communications 3: Article number: 1288 (2012); Published: 18 December 2012; Updated: 21 May 2013. While this Article was undergoing peer review,…”
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