Search Results - "Marin, Violeta"

2‑Aryl-5-carboxytetrazole as a New Photoaffinity Label for Drug Target Identification by Herner, András, Marjanovic, Jasmina, Lewandowski, Tracey M, Marin, Violeta, Patterson, Melanie, Miesbauer, Laura, Ready, Damien, Williams, Jon, Vasudevan, Anil, Lin, Qing

“…Photoaffinity labels are powerful tools for dissecting ligand–protein interactions, and they have a broad utility in medicinal chemistry and drug discovery…”
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CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16 by Shergalis, Andrea G., Marin, Violeta L., Rhee, David Y., Senaweera, Sameera, McCloud, Rebecca L., Ronau, Judith A., Hutchins, Charles W., McLoughlin, Shaun, Woller, Kevin R., Warder, Scott E., Vasudevan, Anil, Reitsma, Justin M.

“…Molecular glues (MGs) are monovalent small molecules that induce an interaction between proteins (native or non-native partners) by altering the…”
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Quantitative Measurement of Rate of Targeted Protein Degradation by Lynch, Thomas L., Marin, Violeta L., McClure, Ryan A., Phipps, Colin, Ronau, Judith A., Rouhimoghadam, Milad, Adams, Ashley M., Kandi, Soumya, Wolke, Malerie L., Shergalis, Andrea G., Potts, Gregory K., Nacham, Omprakash, Richardson, Paul, Kakavas, Stephan J., Chhor, Gekleng, Jenkins, Gary J., Woller, Kevin R., Warder, Scott E., Vasudevan, Anil, Reitsma, Justin M.

“…Targeted protein degradation (TPD) is a therapeutic approach that leverages the cell’s natural machinery to degrade targets instead of inhibiting them. This is…”
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Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain – A fragment based approach by Upadhyay, Anup K., Judge, Russell A., Li, Leiming, Pithawalla, Ron, Simanis, Justin, Bodelle, Pierre M., Marin, Violeta L., Henry, Rodger F., Petros, Andrew M., Sun, Chaohong

“…[Display omitted] •Identified fragment 1a that competes with H3K4me3 binding in KDM4A TUDOR domain.•X-ray structure of KDM4A TUDOR domain in complex with 1a is…”
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Diet of the marsh deer in the Paraná River Delta, Argentina—a vulnerable species in an intensive forestry landscape by Marin, Violeta C., Fernández, Vanina A., Dacar, María Ana, Gutiérrez, Diego G., Fergnani, Darío, Pereira, Javier A.

“…The marsh deer ( Blastocerus dichotomus ) is the largest deer native to South America, occurring in wetlands and marshy habitats. The southernmost population…”
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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) by Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

“…[Display omitted] Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate…”
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Functional Assays of Membrane-Bound Proteins with SAMDI-TOF Mass Spectrometry by Marin, Violeta L, Bayburt, Timothy H, Sligar, Stephen G, Mrksich, Milan

“…Delicate probing: When nanodisc assemblies are used to present membrane proteins on a biochip surface, interactions of these proteins can be studied by mass…”
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Glycan-Mediated, Ligand-Controlled Click Chemistry for Drug-Target Identification by Stöckmann, Henning, Marin, Violeta L., Nimmer, Paul, Balut, Corina M., Davidson, Donald J., Richardson, Paul L., Vasudevan, Anil

“…Membrane‐bound proteins are important pharmaceutical drug targets, yet few strategies exist for the identification of small‐molecule‐targeted membrane proteins…”
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Controlling cellular distribution of drugs with permeability modifying moieties by Richardson, Paul L, Marin, Violeta L, Koeniger, Stormy L, Baranczak, Aleksandra, Wilsbacher, Julie L, Kovar, Peter J, Bacon-Trusk, Patricia E, Cheng, Min, Hopkins, Todd A, Haman, Sandra T, Vasudevan, Anil

“…Phenotypic screening provides compounds with very limited target cellular localization data. In order to select the most appropriate target identification…”
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Hybridization of Complementary and Homologous Peptide Nucleic Acid Oligomers to a Guanine Quadruplex-Forming RNA by Marin, Violeta L, Armitage, Bruce A

“…Peptide nucleic acid (PNA) oligomers targeted to guanine quadruplex-forming RNAs can be designed in two different ways. First, complementary cytosine-rich PNAs…”
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Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8 by Judge, Russell A, Zhu, Haizhong, Upadhyay, Anup K, Bodelle, Pierre M, Hutchins, Charles W, Torrent, Maricel, Marin, Violeta L, Yu, Wenyu, Vedadi, Masoud, Li, Fengling, Brown, Peter J, Pappano, William N, Sun, Chaohong, Petros, Andrew M

“…SETD8 is a histone H4–K20 methyltransferase that plays an essential role in the maintenance of genomic integrity during mitosis and in DNA damage repair,…”
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Correlations between Diabetes Mellitus Self-Care Activities and Glycaemic Control in the Adult Population: A Cross-Sectional Study by Popoviciu, Mihaela Simona, Marin, Violeta Nicoleta, Vesa, Cosmin Mihai, Stefan, Simona Diana, Stoica, Roxana Adriana, Serafinceanu, Cristian, Merlo, Emanuele Maria, Rizvi, Ali A, Rizzo, Manfredi, Busnatu, Stefan, Stoian, Anca Pantea

“…Although it is well known that lifestyle changes can affect plasma glucose levels, there is little formal evidence for the sustained effectiveness of exercise…”
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RNA Guanine Quadruplex Invasion by Complementary and Homologous PNA Probes by Marin, Violeta L., Armitage, Bruce A.

“…Guanine quadruplexes are gaining increasing attention due to their suspected roles in regulating gene expression at the transcriptional and translational…”
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Recent advances in the development of peptide nucleic acid as a gene-targeted drug by Marin, Violeta L, Roy, Subhadeep, Armitage, Bruce A

“…Peptide nucleic acid (PNA) is a non-ionic mimic of DNA that binds to complementary DNA and RNA sequences with high affinity and selectivity. Targeting of…”
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Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023–January 2024 by Laniece Delaunay, Charlotte, Melo, Aryse, Maurel, Marine, Mazagatos, Clara, Goerlitz, Luise, O’Donnell, Joan, Oroszi, Beatrix, Sève, Noémie, Rodrigues, Ana Paula, Martínez-Baz, Iván, Meijer, Adam, Mlinarić, Ivan, Latorre-Margalef, Neus, Lazăr, Mihaela, Pérez-Gimeno, Gloria, Dürrwald, Ralf, Bennett, Charlene, Túri, Gergő, Rameix-Welti, Marie-Anne, Guiomar, Raquel, Castilla, Jesús, Hooiveld, Mariëtte, Kurečić Filipović, Sanja, Samuelsson Hagey, Tove, Dijkstra, Frederika, Borges, Vitor, Ramos Marín, Violeta, Bacci, Sabrina, Kaczmarek, Marlena, Kissling, Esther

“…In autumn 2023, European vaccination campaigns predominantly administered XBB.1.5 vaccine. In a European multicentre study, we estimated 2023 COVID-19 vaccine…”
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Severity of respiratory syncytial virus compared with SARS-CoV-2 and influenza among hospitalised adults ≥65 years by Vega-Piris, Lorena, Carretero, Silvia Galindo, Mayordomo, José Luis, Zarzuelo, Mercedes Belén Rumayor, Río, Virginia Álvarez, García, Virtudes Gallardo, Vázquez, Miriam García, Rodríguez, María del Carmen García, Basile, Luca, González-Coviella, Nieves López, Boada, Maria Isabel Barranco, Pérez-Martínez, Olaia, Azevedo, Ana Lameiras, Rubio, Carmen Quiñones, Duran, Jaume Giménez, Ibáñez, Ana Fernández, Rivera, María Victoria García, Marín, Violeta Ramos, Castrillejo, Daniel, Raymundo, Luis Javier Viloria, Larrauri, Amparo, Monge, Susana

“…Our aim was to estimate the risk of pneumonia, admission to intensive care unit (ICU) or death in individuals ≥65 years old admitted to hospital with RSV,…”
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Effectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24 by Pérez-Gimeno, Gloria, Mazagatos, Clara, Lorusso, Nicola, Basile, Luca, Martínez-Pino, Isabel, Corpas Burgos, Francisca, Batalla Rebolla, Noa, Rumayor Zarzuelo, Mercedes B, Andreu Ivorra, Blanca, Giménez Duran, Jaume, Castrillejo, Daniel, Guiu Cañete, Inés, Huerta Huerta, Marta, García Becerril, Marta, Ramos Marín, Violeta, Casas, Inmaculada, Pozo, Francisco, Monge, Susana

“…During 2023/24, all children aged 6 to 59 months were targeted for seasonal influenza vaccination in Spain nationally. Using a test-negative case-control…”
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Estimated Impact of Nirsevimab on the Incidence of Respiratory Syncytial Virus Infections Requiring Hospital Admission in Children < 1 Year, Weeks 40, 2023, to 8, 2024, Spain by Mazagatos, Clara, Mendioroz, Jacobo, Rumayor, Mercedes Belén, Gallardo García, Virtudes, Álvarez Río, Virginia, Cebollada Gracia, Ana Delia, Batalla Rebollo, Noa, Barranco Boada, María Isabel, Pérez‐Martínez, Olaia, Lameiras Azevedo, Ana Sofía, López González‐Coviella, Nieves, Castrillejo, Daniel, Fernández Ibáñez, Ana, Giménez Duran, Jaume, Ramírez Córcoles, Cristina, Ramos Marín, Violeta, Larrauri, Amparo, Monge, Susana, Basile, Luca, García Comas, Luis, Lorusso, Nicola, Pacheco Martínez, María del Carmen, Rodríguez Martí, Cristina, Linares Dópido, Juan Antonio, Sánchez‐Migallon Naranjo, Alonso, Otero‐Barrós, María Teresa, Lopez Torrijos, Miriam, Rivas Wagner, Eva, Hermoso Castro, Luisa F., Huerta Huerta, Marta, Reina Prieto, Jorge, Gómez Juárez, Ana, Ruiz Nuñez, Aranzazu, González Carril, Fernando, Imaz Goienetxea, Liher, Ibáñez Pérez, Ana Carmen, Berradre Saenz, Belén, Puma Olguin, Tania, Pérez Gimeno, Gloria, Galindo Carretero, Silvia, Vega Piris, Lorena, Lozano, Marcos

“…ABSTRACT Background Data from the sentinel surveillance system of severe acute respiratory infections in Spain were used to estimate the impact of…”
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Effect of LNA Modifications on Small Molecule Binding to Nucleic Acids by Marin, Violeta, Hansen, Henrik F., Koch, Troels, Armitage, Bruce A.

“…Locked nucleic acid (LNA) is a conformationally constrained DNA analogue that exhibits exceptionally high affinity for complementary DNA and RNA strands. The…”
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Corrigendum to “Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: results from the VEBIS primary care test-negative design study, September 2023–January 2024” [Vaccine 42(19) (2024)] by Laniece Delaunay, Charlotte, Melo, Aryse, Maurel, Marine, Mazagatos, Clara, Goerlitz, Luise, O’Donnell, Joan, Oroszi, Beatrix, Sève, Noémie, Paula Rodrigues, Ana, Martínez-Baz, Iván, Meijer, Adam, Mlinarić, Ivan, Latorre-Margalef, Neus, Lazăr, Mihaela, Pérez-Gimeno, Gloria, Dürrwald, Ralf, Bennett, Charlene, Túri, Gergő, Rameix-Welti, Marie-Anne, Guiomar, Raquel, Castilla, Jesús, Hooiveld, Mariëtte, Kurečić Filipović, Sanja, Samuelsson Hagey, Tove, Dijkstra, Frederika, Borges, Vitor, Ramos Marín, Violeta, Bacci, Sabrina, Kaczmarek, Marlena, Kissling, Esther

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