Search Results - "Marik, Paul E."

Vitamin C for the treatment of sepsis: The scientific rationale by Marik, Paul E.

“…Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is…”
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Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19) by Colunga Biancatelli, Ruben Manuel Luciano, Berrill, Max, Catravas, John D, Marik, Paul E

“…Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May…”
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Critical illness-related corticosteroid insufficiency by Marik, Paul E

“…The diagnosis of adrenal failure and the indications for corticosteroid therapy in critically ill patients are controversial. This controversy is fueled by the…”
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Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 by Kory, Pierre, Meduri, Gianfranco Umberto, Varon, Joseph, Iglesias, Jose, Marik, Paul E

“…After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective…”
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Fluid administration in severe sepsis and septic shock, patterns and outcomes: an analysis of a large national database by Marik, Paul E., Linde-Zwirble, Walter T., Bittner, Edward A., Sahatjian, Jennifer, Hansell, Douglas

“…Purpose The optimal strategy of fluid resuscitation in the early hours of severe sepsis and septic shock is controversial, with both an aggressive and…”
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Prediction of fluid responsiveness: an update by Monnet, Xavier, Marik, Paul E., Teboul, Jean-Louis

“…In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has…”
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Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid by Marik, Paul E

“…Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted…”
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Is intravenous vitamin C contraindicated in patients with G6PD deficiency? by Marik, Paul E

“…Keywords: Vitamin C, G6PD deficiency, Sepsis, Septic shock, Clinical trials…”
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Noninvasive Cardiac Output Monitors: A State-of the-Art Review by Marik, Paul E., MD, FCCM, FCCP

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Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction by Barabutis, Nektarios, Khangoora, Vikramjit, Marik, Paul E., Catravas, John D.

“…Sepsis refers to the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a…”
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The role of glucocorticoids as adjunctive treatment for sepsis in the modern era by Marik, Paul E

“…Glucocorticoids have been used as adjunctive therapy in patients with sepsis and septic shock for more than four decades. The rationale for the use of…”
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A scoping review of the pathophysiology of COVID-19 by Marik, Paul E, Iglesias, Jose, Varon, Joseph, Kory, Pierre

“…COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to…”
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Iatrogenic salt water drowning and the hazards of a high central venous pressure by Marik, Paul E

“…Current teaching and guidelines suggest that aggressive fluid resuscitation is the best initial approach to the patient with hemodynamic instability. The…”
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Normocaloric versus hypocaloric feeding on the outcomes of ICU patients: a systematic review and meta-analysis by Marik, Paul E., Hooper, Michael H.

“…Introduction Current clinical practice guidelines recommend providing ICU patients a daily caloric intake estimated to match 80–100 % of energy expenditure…”
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Extended Anticoagulant and Aspirin Treatment for the Secondary Prevention of Thromboembolic Disease: A Systematic Review and Meta-Analysis by Marik, Paul E, Cavallazzi, Rodrigo

“…Patients who have had an unprovoked deep venous thrombosis (DVT) or pulmonary embolus (PE) are at a high risk for recurrent venous thromboembolism (VTE)…”
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Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients—Part II: Cardiac Ultrasonography by Levitov, Alexander, Frankel, Heidi L., Blaivas, Michael, Kirkpatrick, Andrew W., Su, Erik, Evans, David, Summerfield, Douglas T., Slonim, Anthony, Breitkreutz, Raoul, Price, Susanna, McLaughlin, Matthew, Marik, Paul E., Elbarbary, Mahmoud

“…To establish evidence-based guidelines for the use of bedside cardiac ultrasound, echocardiography, in the ICU and equivalent care sites. Grading of…”
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Omega‐3 Dietary Supplements and the Risk of Cardiovascular Events: A Systematic Review by Marik, Paul E., Varon, Joseph

“…Background Epidemiologic data suggest that omega‐3 fatty acids derived from fish oil reduce cardiovascular disease. The clinical benefit of dietary fish oil…”
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Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis by Marik, Paul E

“…Keywords: Vitamin C, Sepsis, Septic shock, Procalcitonin, Thiamine, Hydrocortisone…”
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Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19 by Holford, Patrick, Carr, Anitra C, Jovic, Thomas H, Ali, Stephen R, Whitaker, Iain S, Marik, Paul E, Smith, A David

“…There are limited proven therapies for COVID-19. Vitamin C's antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic…”
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The Use of Bioreactance and Carotid Doppler to Determine Volume Responsiveness and Blood Flow Redistribution Following Passive Leg Raising in Hemodynamically Unstable Patients by Marik, Paul E., MD, Levitov, Alex, MD, RDCS, FCCP, Young, Alisha, MD, Andrews, Lois, RN-BC, MSN, CCRN, ACNS-BC

“…Background The clinical assessment of intravascular volume status and volume responsiveness is one of the most difficult tasks in critical care medicine…”
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