Search Results - "Marijt, Koen"

To TAP or not to TAP: alternative peptides for immunotherapy of cancer by Marijt, Koen A., van Hall, Thorbald

“…•TAP function is often abrogated in malignant and virus-infected cells.•TAP-deficiency allows presentation of an alternative immunopeptidome.•TAP-independent…”
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TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I low cancers by Marijt, Koen A, Doorduijn, Elien M, van Hall, Thorbald

“…T-cell based immunotherapies through checkpoint blockade or adoptive transfer are effective treatments for a wide range of cancers like melanomas and lung…”
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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines by van Montfoort, Nadine, Borst, Linda, Korrer, Michael J., Sluijter, Marjolein, Marijt, Koen A., Santegoets, Saskia J., van Ham, Vanessa J., Ehsan, Ilina, Charoentong, Pornpimol, André, Pascale, Wagtmann, Nicolai, Welters, Marij J.P., Kim, Young J., Piersma, Sytse J., van der Burg, Sjoerd H., van Hall, Thorbald

“…Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor NKG2A, particularly in immune-reactive environments and after…”
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Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages by Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Amoozgar, Zohreh, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.

“…Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2)…”
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Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies by Rostamian, Somayeh, le Cessie, Saskia, Marijt, Koen A, Jukema, J Wouter, Mooijaart, Simon P, van Buchem, Mark A, van Hall, Thorbald, Gussekloo, Jacobijn, Trompet, Stella

“…Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death…”
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PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy by Kleinovink, Jan Willem, Marijt, Koen A., Schoonderwoerd, Mark J. A., van Hall, Thorbald, Ossendorp, Ferry, Fransen, Marieke F.

“…Immunotherapy with PD-1/PD-L1-blocking antibodies is clinically effective for several tumor types, but the mechanism is not fully understood. PD-L1 expression…”
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Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy by Logtenberg, Meike E. W., Jansen, J. H. Marco, Raaben, Matthijs, Toebes, Mireille, Franke, Katka, Brandsma, Arianne M., Matlung, Hanke L., Fauster, Astrid, Gomez-Eerland, Raquel, Bakker, Noor A. M., van der Schot, Simone, Marijt, Koen A., Verdoes, Martijn, Haanen, John B. A. G., van den Berg, Joost H., Neefjes, Jacques, van den Berg, Timo K., Brummelkamp, Thijn R., Leusen, Jeanette H. W., Scheeren, Ferenc A., Schumacher, Ton N.

“…Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression…”
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Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity by Garrido, Greta, Schrand, Brett, Rabasa, Ailem, Levay, Agata, D’Eramo, Francesca, Berezhnoy, Alexey, Modi, Shrey, Gefen, Tal, Marijt, Koen, Doorduijn, Elien, Dudeja, Vikas, van Hall, Thorbald, Gilboa, Eli

“…Neoantigen burden is a major determinant of tumor immunogenicity, underscored by recent clinical experience with checkpoint blockade therapy. Yet the majority…”
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Identification of non-mutated neoantigens presented by TAP-deficient tumors by Marijt, Koen A, Blijleven, Laura, Verdegaal, Els M E, Kester, Michel G, Kowalewski, Daniel J, Rammensee, Hans-Georg, Stevanović, Stefan, Heemskerk, Mirjam H M, van der Burg, Sjoerd H, van Hall, Thorbald

“…Most T cell-based immunotherapies of cancer depend on intact antigen presentation by HLA class I molecules (HLA-I). However, defects in the antigen-processing…”
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TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class Ilow cancers by Marijt, Koen A., Doorduijn, Elien M., van Hall, Thorbald

“…•Downregulation of MHC-I expression common method by which tumors evade immune recognition.•Alternative peptide repertoire presented on cells with defect in…”
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Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling by Marijt, Koen A, Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie H, Scheeren, Ferenc A, van der Burg, Sjoerd H, van Hall, Thorbald

“…T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently…”
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Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement by Marijt, Koen A., Griffioen, Lisa, Blijleven, Laura, van der Burg, Sjoerd. H., van Hall, Thorbald

“…Cancer cells frequently display defects in their antigen-processing pathway and thereby evade CD8 T cell immunity. We described a novel category of cancer…”
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Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer by Kroon, Jan, Puhr, Martin, Buijs, Jeroen T, van der Horst, Geertje, Hemmer, Daniëlle M, Marijt, Koen A, Hwang, Ming S, Masood, Motasim, Grimm, Stefan, Storm, Gert, Metselaar, Josbert M, Meijer, Onno C, Culig, Zoran, van der Pluijm, Gabri

“…Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used in combination with…”
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Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model by Lau, Sai Ping, van Montfoort, Nadine, Kinderman, Priscilla, Lukkes, Melanie, Klaase, Larissa, van Nimwegen, Menno, van Gulijk, Mandy, Dumas, Jasper, Mustafa, Dana A M, Lievense, Sanne L A, Groeneveldt, Christianne, Stadhouders, Ralph, Li, Yunlei, Stubbs, Andrew, Marijt, Koen A, Vroman, Heleen, van der Burg, Sjoerd H, Aerts, Joachim, van Hall, Thorbald, Dammeijer, Floris, van Eijck, Casper H J

“…Pancreatic ductal adenocarcinoma (PDAC) is notoriously resistant to treatment including checkpoint-blockade immunotherapy. We hypothesized that a bimodal…”
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TEIPP peptides: exploration of unTAPped cancer antigens by Marijt, Koen A., Van Der Burg, Sjoerd H., van Hall, Thorbald

“…The intracellular peptide pump TAP feeds antigenic peptides for loading onto HLA class I molecules, and its down-modulation is a frequent immune evasion…”
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T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy by Doorduijn, Elien M., Sluijter, Marjolein, Marijt, Koen A., Querido, Bianca J., van der Burg, Sjoerd H., van Hall, Thorbald

“…Cancers frequently evade immune-recognition by lowering peptide:MHC-I complexes on their cell surface. Limited peptide supply due to TAP-deficiency results in…”
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Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors by Garrido, Greta, Schrand, Brett, Levay, Agata, Rabasa, Ailem, Ferrantella, Anthony, Da Silva, Diane M, D'Eramo, Francesca, Marijt, Koen A, Zhang, Zhuoran, Kwon, Deukwoo, Kortylewski, Marcin, Kast, W Martin, Dudeja, Vikas, van Hall, Thorbald, Gilboa, Eli

“…Vaccination of patients against neoantigens expressed in concurrent tumors, recurrent tumors, or tumors developing in individuals at risk of cancer is posing…”
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Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages by Amoozgar, Zohreh, Peterson, Teresa E., Kirkpatrick, Nathaniel D., Huang, Yuhui, Farrar, Christian T., Marijt, Koen A., Kloepper, Jonas, Datta, Meenal, Seano, Giorgio, Jung, Keehoon, Kamoun, Walid S., Vardam, Trupti, Snuderl, Matija, Goveia, Jermaine, Chatterjee, Sampurna, Batista, Ana, Muzikansky, Alona, Leow, Ching Ching, Xu, Lei, Batchelor, Tracy T., Duda, Dan G., Fukumura, Dai, Jain, Jain K.

“…OBJECTIVE: Here we aimed to overcome resistance to anti-VEGF therapy in glioblastoma (GBM), the most common and aggressive adult primary brain tumor…”
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Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFN[gamma] receptor signaling by Marijt, Koen A, Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie H, Scheeren, Ferenc A, van der Burg, Sjoerd H, van Hall, Thorbald

“…Background T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation,…”
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