Search Results - "Mariela López"
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Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts
Published in Genome Biology (28-06-2021)“…Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing…”
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High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance
Published in Nature communications (22-09-2022)“…Following CART-19 immunotherapy for B-cell acute lymphoblastic leukaemia (B-ALL), many patients relapse due to loss of the cognate CD19 epitope. Since epitope…”
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Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
Published in Nature communications (17-08-2018)“…Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly…”
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4
The Perception of Postalveolar English Obstruents by Spanish Speakers Learning English as a Foreign Language in Mexico
Published in Languages (Basel) (01-06-2020)“…The present study deals with the perception (identification and discrimination) of an English phonemic contrast (/t∫/–/∫/, as in cheat and sheet) by speakers…”
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Short‐term effect of the inoculation of probiotics in mature bioflocs: Water quality parameters and abundance of heterotrophic and ammonia‐oxidizing bacteria
Published in Aquaculture research (01-01-2020)“…The aim of this study was to evaluate the short‐term effect of probiotic inoculation on the abundance of heterotrophic and ammonia‐oxidizing bacteria in mature…”
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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
Published in Cell stem cell (07-09-2023)“…RNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of dysregulated splicing in hematopoiesis remains unclear. To overcome…”
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Utility of a Fluid Library with Samples of Humans, Reservoirs and Vectors Collected in Filter Paper, for Retrospective Diagnosis of American Trypanosomiasis in Endemic Areas of Venezuela
Published in Acta parasitologica (01-03-2021)“…Introduction We define a fluid library as a library of samples of different biological fluids (from humans, animals or vectors) collected and properly stored…”
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Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL
Published in Oncoimmunology (31-12-2023)“…Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted…”
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Major carbon losses from degradation of Mauritia flexuosa peat swamp forests in western Amazonia
Published in Biogeochemistry (01-04-2024)“…Tropical peat swamp forests are major global carbon (C) stores highly vulnerable to human intervention. In Peruvian Amazonia, palm swamps, the prevalent peat…”
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PyNTTTTGT and CpG immunostimulatory oligonucleotides: effect on granulocyte/monocyte colony-stimulating factor (GM-CSF) secretion by human CD56+ (NK and NKT) cells
Published in PloS one (23-02-2015)“…CD56+ cells have been recognized as being involved in bridging the innate and acquired immune systems. Herein, we assessed the effect of two major classes of…”
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11
Using two tools to identify Potentially Inappropriate Medications (PIM) in elderly patients in Southern Chile
Published in Archives of gerontology and geriatrics (01-11-2016)“…Highlights • Prescribing of PIM is a prevalent problem in hospitalized elderly patients. • Polypharmacy, length of stay and older patient age are related with…”
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Spatial and temporal variability of soil N2O and CH4 fluxes along a degradation gradient in a palm swamp peat forest in the Peruvian Amazon
Published in Global change biology (01-12-2020)“…Mauritia flexuosa palm swamp, the prevailing Peruvian Amazon peatland ecosystem, is extensively threatened by degradation. The unsustainable practice of…”
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13
Global accumulation of circRNAs during aging in Caenorhabditis elegans
Published in BMC genomics (03-01-2018)“…Circular RNAs (CircRNAs) are a newly appreciated class of RNAs that lack free 5' and 3' ends, are expressed by the thousands in diverse forms of life, and are…”
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14
CircRNA accumulation in the aging mouse brain
Published in Scientific reports (13-12-2016)“…Circular RNAs (circRNAs) are a newly appreciated class of RNAs expressed across diverse phyla. These enigmatic transcripts are most commonly generated by…”
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Genetic variability of Trypanosoma cruzi TcI isolates from rural and urban areas of Venezuela
Published in Journal of vector borne diseases (2015)“…Several studies have demonstrated genetic heterogeneity in populations of Trypanosoma cruzi that allowed the identification of six different discrete typing…”
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Emerging Functions of Circular RNAs
Published in The Yale journal of biology & medicine (01-12-2016)“…Many thousands of Circular RNAs (circRNAs) have recently been identified in metazoan genomes by transcriptome-wide sequencing. Most circRNAs are generated by…”
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17
Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
Published in eLife (06-06-2017)“…Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that…”
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Evaluación diagnóstica de habilidades de pensamiento e informacionales a través del diseño y aplicación de tres instrumentos para estudiantes de primer grado de educación primaria
Published in Revista educare (01-12-2020)“…This article takes as reference the problems that exist due to the lack of reading, mathematics and science skills, according to the reality of the Mexican…”
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Diagnóstico de factores de riesgo de niños en albergue: Una propuesta estratégica para su desarrollo integral
Published in Revista Scientific (05-11-2020)“…Es una propuesta de tipo cualitativa mediante un diagnóstico preventivo en albergue situado en Chihuahua, cuyo objetivo es realizar un currículo para atender y…”
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20
Alfabetización Informacional: enseñanza y desarrollo de su competencia en la educación básica
Published in E-ciencias de la información (01-12-2019)“…Este artículo presenta los resultados de una investigación sobre la enseñanza de Alfabetización Informacional (ALFIN) en la educación básica, cuyo objetivo fue…”
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